Formulation of Microemulsion of Cayenne Pepper (Capsicum Frutescens L.) Ethanol Extract and Hair Growth Activity Test
Deni Anggraini(1*), Nofri Hendri Sandi(2), Meiriza Djohari(3)
(1) Departement of Pharmaceutic, Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
(2) Departement of Pharmaceutic, Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
(3) Departement of Pharmaceutic, Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru
(*) Corresponding Author
Abstract
Cayenne pepper contains capsaicin, which exhibits properties that promote hair growth. Microemulsion is an oil and water dispersion system with a particle size of 10-200 nm which can be used topically as a drug delivery system through the scalp to stimulate hair growth. The microemulsion was made with olive oil and tween 80 as surfactants and stirred using a magnetic stirrer at 1000 rpm for 3 minutes. The ethanol extract of cayenne pepper was prepared in microemulsions at three different concentrations: 0.1%, 0.2%, and 0.3%. Microemulsion tests included organoleptic tests, specific gravity, pH, viscosity, freezing and thawing stability tests, and hair growth activity tests on rabbits. The results showed that the microemulsion of cayenne pepper ethanol extract at concentrations of 0.1%, 0.2%, and 0.3% was quite stable with a clear appearance and a particle size ranging from 27.7 nm to 167.8 nm. The microemulsion of cayenne pepper ethanol extract at a concentration of 0.2% was the most effective in enhancing hair growth, achieving a hair growth length of 1.27 over a 30-day period. A two-way ANOVA statistical test showed that the hair length of rabbits using microemulsion was significantly different from the hair length of negative control animals at p<0.05.
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Ide, P (2011) Mencegah Kebotakan Dini. PT. Elex Media Komputindo.
Mentzel, T., & Bierhoff, E. (2020). Inflammatory dermatoses. Pathologe, 41(4), 299–300. https://doi.org/10.1007/s00292-020-00787-8
Shapiro J (2002), Hair Loss: Principles of Diagnosis and Management of Alopecia. UK. Martin Dunitz
Harada, N., Okajima, K., Arai, M., Kurihara, H., & Nakagata, N. (2007). Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia. Growth Hormone and IGF Research, 17(5), 408–415. https://doi.org/10.1016/j.ghir.2007.04.009
Duque-Estrada, B., Tosti, A., Mcelwee, K. J., Gilhar, A., Keren, A., Bertolini, M., Shoenfeld, Y., Nakamura, M., Tokura, Y., Sundberg, J. P., King, L. E., Ramot, Y., Zlotogorski, A., Tobin, D. J., Paus, R., Inui, S., & Itami, S. (2013). What causes alopecia areata?: Section Editors: Ralf Paus, Manchester/Lübeck and Raymond Cho, San Francisco Controversies in Experimental Dermatology: What causes alopecia areata? Experimental Dermatology, 22(9), 609–626. https://doi.org/10.1111/exd.12209
Ktiouet, S., Bertrand, Y., Rival-Tringali, A. L., Kanitakis, J., Malcus, C., Poitevin, F., Picard, C., Claudy, A., & Faure, M. (2009) Omenn syndrome due to mutation of the RAG2 gene. Journal of the European Academy of Dermatology and Venereology, 23(12), 1449–1451. https://doi.org/10.1111/j.1468-3083.2009.03232.x
Johnson, W. (2007), Final report on the safety assessment of Capsicum annuum extract, Capsicum annuum fruit extract, Capsicum annuum resin, Capsicum annuum fruit powder, Capsicum frutescens fruit, Capsicum frutescens fruit extract, Capsicum frutescens resin, and Capsaicin. International Journal of Toxicology, 26 (SUPPL.1), 3–106.https://doi.org/10.1080/10915810601163939
Santos, P., Watkinson, A. C., Hadgraft, J., & Lane, M. E. (2008). Application of microemulsions in dermal and transdermal drug delivery. Skin Pharmacology and Physiology, 21(5), 246–259. https://doi.org/10.1159/000140228
Gunthorpe, M. J., Benham, C. D., Randall, A., & Davis, J. B. (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends in Pharmacological Sciences, 23(4), 183–191.https://doi.org/10.1016/S0165 6147(02)01999-5
Grampurohit, N., P. Ravikumar, and R. Mallya, (2011) Microemulsions For Topical Use– A Review, Indian Journal of Pharmaceutical Education and Research, 45, 100-107
Maleki Dizaj, S. (2013). Preparation and study of vitamin A palmitate microemulsion drug delivery system and investigation of co-surfactant effect. Journal of Nanostructure in Chemistry, 3(1). https://doi.org/10.1186/2193-8865-3-59
Khor, Y. P., Koh, S. P., Long, K., Long, S., Ahmad, S. Z. S., & Tan, C. P. (2014). A comparative study of the physicochemical properties of a virgin coconut oil emulsion and commercial food supplement emulsions. Molecules, 19(7), 9187–9202. https://doi.org/10.3390/molecules19079187
Kreilgaard, M. (2002). Influence of microemulsions on cutaneous drug delivery. Advanced Drug Delivery Reviews, 54(SUPPL.). https://doi.org/10.1016/S0169-409X(02)00116-3
Lawrence, M. J., & Rees, G. D. (2012) Microemulsion-based media as novel drug delivery systems. Advanced Drug Delivery Reviews, 64(SUPPL.),175–193. https://doi.org/10.1016/j.addr.2012.09.018
Binarjo, A., & Nugroho, A. K. (2014). Permeasi Transdermal Losartan In Vitro dari Larutan dengan Variasi Kadar Losartan dan Propilen Glikol. Jurnal Kimia VALENSI, 2014 4(1). https://doi.org/10.15408/jkv.v4i1.1046
Rowe RC, Sheskey PJ, Quinn ME. (2006). Handbook of Pharmaceutical Excipients, 5th Edition. Midland (US): Pharmaceutical Press and American Pharmacist
Shah I., (2011) Development and Characterization of Oil in Water Nanoemultions from Self-Microemulsifying Mixtures. (theses and dissertations). University of Toledo.
Sinko, P.J.Martin, (2011) Farmasi Fisika dan Ilmu Farmasetika edisi 5, Penerbit Buku Kedokteran EGC, Jakarta.
Bodó, E., Bíró, T., Telek, A., Czifra, G., Griger, Z., Tóth, B. I., Mescalchin, A., Ito, T., Bettermann, A., Kovács, L., & Paus, R. (2005). A hot new twist to hair biology: Involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in
human hair growth control. American Journal of Pathology, 166(4), 985–998. https://doi.org/10.1016/S0002-9440(10)62320-6
DOI: https://doi.org/10.22146/mot.87206
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Faculty of Pharmacy
Universitas Gadjah Mada