Topical Application Type of Fish Oil Promotes Re-Epithelialization in Burn Wound Healing in Rats

https://doi.org/10.22146/mot.95644

Heru Sasongko(1*), Nirwana Asri Diah Pitaloka(2), Muhammad Rizki Kurniawan(3), Edi Pramono(4), Novan Adi Setyawan(5), Abdul Rohman(6)

(1) Department of Pharmacy, Vocational School, Sebelas Maret University, Jl. Ir. Sutami No. 36A Surakarta, Central Java
(2) Department of Pharmacy, Vocational School, Sebelas Maret University, Jl. Ir. Sutami No. 36A Surakarta, Central Java
(3) Department of Pharmacy, Vocational School, Sebelas Maret University, Jl. Ir. Sutami No. 36A Surakarta, Central Java
(4) Department of Chemistry, Faculty of Mathematics and Natural Science, Sebelas Maret University, Jl. Ir. Sutami No. 36A Surakarta, Central Java
(5) Pathology and Anatomy Laboratory, Faculty of Medicine Sebelas Maret University, Sebelas Maret University, Jl. Ir. Sutami No. 36A Surakarta, Central Java
(6) Center of Excellence, Institute for Halal Industry and Systems, Gadjah Mada University, Yogyakarta
(*) Corresponding Author

Abstract


Burns are a condition that is often found in the world in various cases such as accidents. The incidence of burns will probably increase as human activities become more complex. Wounds that are not treated immediately tend to become infected and cause death. Fish oil is one of the ingredients that has been studied for wound healing. Previous research shows that fish oil is rich in long-chain omega-3 fatty acids such as docosahexaenoic acid and eicosapentaenoic acid, which have anti-inflammatory effects. However, there has not been much research on the type of fish oil used and the wound healing process. The aim of this study was to determine the wound-healing activity of milkfish (Chanos chanos Forsskal.), patin (Pangasius djambal), and eel (Anguilla bicolor) fish oil. Tests were carried out on 25 mice as an experimental animal model for burn wounds. Data on percent wound reduction and the re-epithelialization process were statistically calculated using one-way analysis of variance (ANOVA) followed by a post-hoc LSD test. The research results showed that milkfish oil, patin fish oil, and eel fish oil in a concentration of 10% on an ointment basis were able to reduce wounds significantly. Eel fish oil shows the greatest burn wound healing process with re-epithelialization when compared to other oils. The type of fish oil affects the wound healing process.


Keywords


Fish; Omega-3; Wound Healing; Re-Epithelialization

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References

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DOI: https://doi.org/10.22146/mot.95644

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