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Evaluation of Antidiabetic Properties of a Polyherbal Extract (ACCBN) on Alloxan-induced Diabetic Rats
https://doi.org/10.22146/mot.99354 Robert Ikechukwu Uroko(1*), Amarachi Chike-Ekwughe(2), Paul Chukwuemeka Nweje-Anyalowu(3), Chinedu Aguwamba(4)
(1) Michael Okpara University of Agriculture Umudike, Abia State
(2) Department of Life Sciences, Base University, Abuja
(3) Biochemistry Unit, Department of Chemical Sciences, Faculty of Sciences, Owerrinta, Abia State
(4) Biochemistry Unit, Department of Chemical Sciences, Faculty of Sciences, Owerrinta, Abia State
(*) Corresponding Author
Abstract
Diabetes mellitus emanates from a dysfunctional metabolic process and it affects human population globally, and causes a decline in the quality of life and increase in mortality rate due to its complications and adverse effects of the available antidiabetic drugs, thus, there is a need for a better antidiabetic agent. This study assessed the antidiabetic properties of a polyherbal extract (ACCBN) on alloxan-induced diabetic rats to validate its antidiabetic claims in traditional medicine. The diabetic study had 6 groups including normal control, diabetic rats deprived of treatment, diabetic rats administered 5 mg/kg Glibenclamide, and diabetic rats administered 400 and 800 mg/kg ACCBN-extract accordingly and normal rats administered 800 mg/kg ACCBN-extract only. The rats were successfully made diabetic by the administration of alloxan monohydrate intraperitoneally whereas and the rats were treated with either Glibenclamide or ACCBN-extract orally for 28 consecutive days. The acute study of ACCBN-extract indicated lethal dose above 5000 mg/kg. The diabetic rats deprived of treatment showed significantly elevated acute and sub-acute blood glucose levels including significantly elevated glycated haemoglobin concentration and significant decline in the C-peptide and insulin levels relative to the normal control. Diabetic rats administered ACCBN-extract displayed a marked decline in the acute and sub-acute blood glucose levels in comparison to the diabetic rats deprived of treatment. The diabetic rats administered ACCBN-extract displayed a remarkable decline in glycated haemoglobin level and significantly elevated C-peptide and insulin concentrations compared to the diabetic rats deprived of treatment. The outcome revealed that ACCBN-extract possesses sufficient antidiabetic properties and could be effective in the management of diabetes.
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DOI: https://doi.org/10.22146/mot.99354
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