Survival Rates of Colorectal Cancer in Academic Hospital Universitas Gadjah Mada, Yogyakarta: A Cohort Studyada, Yogyakarta: A Cohort Study

https://doi.org/10.22146/ahj.v8i1.115136

Agung Widianto(1*), Wahyu Kartiko Tomo(2), Nistimara Anugrah Azdy(3), Renata Uli Aviola(4), Sekarini Wening Ayu(5)

(1) Universitas Gadjah Mada Academic Hospital
(2) Universitas Gadjah Mada Academic Hospital
(3) Universitas Gadjah Mada Academic Hospital
(4) Universitas Gadjah Mada Academic Hospital
(5) Universitas Gadjah Mada Academic Hospital
(*) Corresponding Author

Abstract


Background:  Colorectal cancer (CRC) is the third most common cancer worldwide. It poses a significant challenge to healthcare systems, including those in Indonesia. This study investigates CRC survival rates and their association with prognostic factors at the Academic Hospital Universitas Gadjah Mada (UGM), Yogyakarta.

Methods: This is a cohort-retrospective study. All patients who were diagnosed with CRC and treated in the Surgery Division of Academic Hospital UGM from January 2019 to December 2023 were enrolled. Kaplan-Meier survival curves were used to estimate overall survival, and the log-rank test was used to compare overall survival between prognostic groups.

Result: The study included 110 patients with CRC. The median follow-up was 713 days. The estimated 1-year overall survival of all CRC patients treated at Academic Hospital UGM was 66.75%. The average Overall Survival (OS) was 752.335 days. Log-rank analysis showed p-values of 0.485, 0.468, 0.437, and < 0.001 for sex, age, cancer stage, and treatment, respectively. Treatment type significantly impacted survival. Patients who underwent surgery alone had a lower OS compared to those treated with surgery plus chemotherapy. Patients who received surgery alone also had 10-fold higher mortality than those who received combination therapy (HR 10.288; CI 95%, 3.603–29.387, p<0.001).

Conclusion: Survival outcomes for colorectal cancer patients vary based on sex, age, stage, and treatment type. Surgery combined with chemotherapy was associated with better OS in CRC patients.


Keywords


colorectal cancer, survival rate, prognostic factors

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References

  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4. PMID: 33538338.
  2. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA. Cancer J. Clin. 2018;68:394–424. doi: 10.3322/caac. 21492
  3. Rahadiani N, Habiburrahman M, Abdullah M, et al. Analysing 11 years of incidence trends, clinicopathological characteristics, and forecasts of colorectal cancer in young and old patients: a retrospective cross-sectional study in an Indonesian national referral hospital. BMJ Open 2022;12:e060839. Doi: 10.1136/bmjopen-2022-060839
  4. Juan Adrian Wiranata, Herindita Puspitaningtyas, Susanna Hilda Hutajulu, Jajah Fachiroh, Nungki Anggorowati, Guardian Yoki Sanjaya, et al. Temporal and spatial analyses of colorectal cancer incidence in Yogyakarta, Indonesia: a cross-sectional study. Geospatial Health. 2023 May 25;18(1).
  5. Kementerian Kesehatan Republik Indonesia. Berita Acara Penilaian Kesesuaian Perizinan Berusaha Kenaikan Kelas Nomor YR.02.01/D/VI.6/710/2025. 2025.
  6. Hashim, D., & Weiderpass, E. (2017). Cancer Survival and Survivorship. Reference Module in Biomedical Sciences. doi:10.1016/b978-0-12-801238-3.65102-4
  7. Labeda I, Lusikooy RE, Mappincara, Dani MI, Sampetoding S, Kusuma MI, Uwuratuw JA, Syarifuddin E, Arsyad A, Faruk M. Colorectal cancer survival rates in Makassar, Eastern Indonesia: A retrospective Cohort Study. Ann Med Surg (Lond). 2021 Dec 30;74:103211. doi: 10.1016/j.amsu.2021.103211. PMID: 35059192; PMCID: PMC8760491.
  8. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14(2):89-103. doi: 10.5114/pg.2018.81072. Epub 2019 Jan 6. PMID: 31616522; PMCID: PMC6791134.
  9. Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA Cancer J Clin. 2023 May-Jun;73(3):233-254. doi: 10.3322/caac.21772. Epub 2023 Mar 1. PMID: 36856579.
  10. Lugli A, Karamitopoulou E, Zlobec I. Tumour budding: a promising parameter in colorectal cancer. Br J Cancer. 2012 May 22;106(11):1713-7. doi: 10.1038/bjc. 2012.127. Epub 2012 Apr 24. PMID: 22531633; PMCID: PMC3364122.
  11. Kumar A, Gautam V, Sandhu A, Rawat K, Sharma A, Saha L. Current and emergingtherapeutic approaches for colorectal cancer: A comprehensive review. World J Gastrointest Surg. 2023 Apr 27;15(4):495-519. doi: 10.4240/wjgs.v15.i4.495. PMID: 37206081; PMCID: PMC10190721.
  12. Mehta HB, Vargas GM, Adhikari D, Dimou F, Riall TS. Comparative effectiveness of chemotherapy vs resection of the primary tumour as the initial treatment in older patients with Stage IV colorectal cancer. Colorectal Dis. 2017 Jun;19(6):O210-O218. doi: 10.1111/codi.13659. PMID: 28304120; PMCID: PMC5457355.
  13. Jeo S.W, Subrata F.H. 2020. The Survival Rate of Colorectal Cancer in Dr Cipto Mangunkusumo Hospital. The New Ropanasuri Journal of Surgery 5(2).
  14. Royle, KL., Meads, D., Visser-Rogers, J.K. et al. How is overall survival assessed in randomised clinical trials in cancer, and are subsequent treatment lines considered? A systematic review. Trials 24, 708 (2023). https://doi.org/10.1186/s13063-023-07730-1
  15. Muhamad NA, Ma'amor NH, Rosli IA, Leman FN, Abdul Mutalip MH, Chan HK, Yusof SN, Tamin NSI, Aris T, Lai NM, Abu Hassan MR. Colorectal cancer survival among the Malaysian population: data from the Malaysian National Cancer Registry. Front Oncol. 2023 Nov 29;13:1132417. doi: 10.3389/fonc.2023.1132417. PMID: 38094603; PMCID: PMC10718645
  16. Benitez Majano S, Di Girolamo C, Rachet B, Maringe C, Guren MG, Glimelius B, Iversen LH, Schnell EA, Lundqvist K, Christensen J, Morris M, Coleman MP, Walters S. Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study. Lancet Oncol. 2019 Jan;20(1):74-87. doi: 10.1016/S1470-2045(18)30646-6. Epub 2018 Dec 10. PMID: 30545752; PMCID: PMC6318222.
  17. Schliemann, D., Ramanathan, K., Matovu, N. et al. The implementation of colorectal cancer screening interventions in low-and middle-income countries: a scoping review. BMC Cancer 21, 1125 (2021). https://doi.org/10.1186/s12885-021-08809-1
  18. RSUP Dr Sardjito and the Faculty Of Medicine Universitas Gadjah Mada. Cancer Registry on Colorectal Cancer. 2021.
  19. Alzahrani SM, Al Doghaither HA, Al-Ghafari AB. General insight into cancer: An overview of colorectal cancer (Review). Mol Clin Oncol. 2021 Dec;15(6):271. doi: 10.3892/mco.2021.2433. Epub 2021 Nov 1. PMID: 34790355; PMCID: PMC8591689.
  20. Lv, Z., Liang, Y., Liu, H. et al. Association of chemotherapy with survival in stage II colon cancer patients who received radical surgery: a retrospective cohort study. BMC Cancer 21, 306 (2021). https://doi.org/10.1186/s12885-021-08057-3
  21. Shervani S, Lu G, Sager K, Wajima T, Wong L. Prognostic factors and hazard ratios in colorectal cancer patients over 80 years of age: a retrospective, 20-year, single institution review. J Gastrointest Oncol. 2018 Apr;9(2):254-262. doi: 10.21037/jgo.2018.01.06. PMID: 29755763; PMCID: PMC5934159.
  22. Mekenkamp LJ, Heesterbeek KJ, Koopman M, Tol J, Teerenstra S, Venderbosch S, Punt CJ, Nagtegaal ID. Mucinous adenocarcinomas: poor prognosis in metastatic colorectal cancer. Eur J Cancer. 2012 Mar;48(4):501-9. doi: 10.1016/j.ejca.2011.12.004. Epub 2012 Jan 4. PMID: 22226571.




DOI: https://doi.org/10.22146/ahj.v8i1.115136

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