Pengaruh kadar low density lipoprotein cholesterol (LDL-C) terhadap derajat keparahan penyakit Parkinson

https://doi.org/10.22146/bns.v18i3.55023

Nita Nathania Agustin(1*), Subagya Subagya(2), Abdul Gofir(3)

(1) KSM Penyakit Saraf, RS Hermina Pasteur, Bandung
(2) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(3) Departemen Neurologi Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Penyakit Parkinson (PP) adalah gangguan neurodegeneratif progresif yang berkaitan dengan usia. Beberapa penelitian terbaru menunjukkan bahwa metabolisme lipid dan kolesterol berperan dalam patogenesis penyakit Parkinson. Diduga peningkatan kadar LDL-C dalam darah dapat memperbaiki kondisi klinis gejala Parkinson. Penelitian ini bertujuan untuk mengetahui pengaruh kadar LDL-C dalam darah terhadap derajat keparahan penyakit Parkinson berdasarkan skala Hoehn & Yahr. Desain penelitian ini menggunakan metode cross sectional pada pasien dengan penyakit Parkinson yang kontrol di Poliklinik Saraf RSUP Dr. Sardjito Yogyakarta, RSUD Tjitrowardoyo Purworejo, RSPAU Hardjo Lukito dan RSUP Soeradji Tirtonegoro Klaten. Empat puluh subjek yang masuk ke dalam kriteria inklusi dilakukan penilaian terhadap skala Hoehn & Yahr (stadium I-V) dan pemeriksaan kadar LDL-C. Semua data dianalisis statistik secara komputerisasi. Jumlah subjek dengan stadium I sebanyak 7 (17,5%) subjek, stadium II sebanyak 18 (45%) subjek, stadium III sebanyak 14 (35%) subjek, stadium IV terdapat 1 (2,5%) subjek dan tidak ada subjek stadium V. Rerata kadar LDL-C adalah 109,55±30,31 mg/dL. Hasil analisis multivariat didapatkan pengaruh kadar LDL-C terhadap skala Hoehn & Yahr tidak signifikan (p =0,153). Penelitian ini tidak mendukung adanya pengaruh kadar LDL-C dalam darah terhadap derajat keparahan penyakit Parkinson berdasarkan skala Hoehn & Yahr.


Keywords


kadar LDL-C, derajat keparahan; penyakit Parkinson; Hoehn & Yahr

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DOI: https://doi.org/10.22146/bns.v18i3.55023

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