Study of creatinine transport through chitosan/pectin/poly(vinyl alcohol) blend membranes

Ni Putu Sri Ayuni; Ni Wayan Yuningrat

doi:10.22146/ijbiotech.25812

Study of creatinine transport through chitosan/pectin/poly(vinyl alcohol) blend membranes

https://doi.org/10.22146/ijbiotech.25812

Ni Putu Sri Ayuni^(1*), Ni Wayan Yuningrat⁽²⁾

(1) Faculty of Mathematics and Natural Sciences, Universitas Pendidikan Ganesha, Jalan Udayana No.11 Singaraja, Bali 81116
(2) Faculty of Mathematics and Natural Sciences, Universitas Pendidikan Ganesha, Jalan Udayana No.11 Singaraja, Bali 81116
(*) Corresponding Author

Abstract

Creatinine was final product of creatine metabolism inskeletal muscle. Increasing of creatinine showed decreasing of kidney function. Kidney fuction decreased could be treated by hemodialysis (HD). One of the natural polymer was cellulose which often used as hemodialysis membrane. Chitosan as natural membrane was used as membrane in this research because the structure was almost similar to cellulose. Chitosan was complexed by pectin and poly(vinil alcohol) (PVA) to fixed mechanical characteristic of membrane. The objective of this research were to synthesize, characterize, and know efficiency of creatinine transport using chitosan/pectin/PVA blend membranes. The functional groups of synthesized membrane were characterized by FTIR spectrophotometer. Efficiency of optimum creatinine transport was known by using membrane with chitosan and pectin ratio70:30 while PVA used 0.5%; 1.0% and 1.5%. The source and acceptor phase resulted were complexed by picric acid and analyzed by Ultraviolet-Visible (UV-Vis) Spectrophotometer. The result of membrane synthesized which was analyzed by FTIR Spectrophotometer shows that there is a band broadening on wave number 3448.72 cm^-1. It is indicated that there are an overlapped stretching of hydrogen bond -OH on PVA and NH₂ on chitosan. The optimum creatinine 70 ppm transported using membrane with 1.5% PVA addition is 59%.

Keywords

chitosan; creatinine; membrane; pectin; poly(vinyl alcohol)

Full Text:

PDF

References

Abraham, S., Venu, A., Ramachandran, A., Chandran, P.M., and Raman, S. 2012. Assessment of quality of life in patients on hemodialysis and the impact of counseling. Saudi J. Dis. Transpl., 23, 953–957.

Ayuni, N.P.S, and Siswanta, D.A.S. 2013. Kajian transpor kreatinin menggunakan membran kompleks polielektrolit (PEC) kitosan-pektin. Wahana Matematika dan Sains., 8(1), 88–96.

Dash, M., Chiellini, F., Ottenbrite, R.M., and Chiellini, E. 2011. Chitosan - A versatile semi-synthetic polymer in biomedical applications. Prog. Polym. Sci., 36, 981–1014.

Gao, A., Liu, F., and Xue, L. 2014. Preparation and evaluation of heparin-immobilized poly (lactic acid) (PLA) membrane for hemodialysis. J. Membr. Sci., 452, 390–399.

Hamilton, R.W., Gardner, A., Penn, A.S., and Goldberg, M. 1972. Acute tubular necrosis caused by exercise-induced myoglobinuria. Ann. Intern. Med., 77, 77–82.

Huangfu, P., Gong, M., Zhang, C., Yang, S., Zhao, J., and Gong, Y. 2009. Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility. Colloids Surf., B., 71, 268–274.

Kerr, P.G., and Huang, L. 2010. Review: membranes for haemodialysis. Nephrology., 15, 381–385.

Levey, A.S., Eckardt, K.U., Tsukamoto, Y., Levin, A., and Coresh, J. 2005. Definition and classification of chronic kidney disease: a position statement from kidney disease: improving global outcomes (KDIGO)z’. Kidney Int., 67, 2089–2100.

Lusiana, R.A., Isdadiyanto, S., and Khabibi. 2016. Urea permeability of citric acid crosslinked chitosan-poly(vinyl alcohol) blend membranes. Int. J. Chem. Eng. Appl., 7, 186–189.

Lusiana, R.A., Siswanta, D., and Hayashita, T. 2013. The influence of PVA. cl. citric acid/chitosan membrane hydrophicility. Indo. J. Chem., 13, 262–270.

Lusiana, R. A., Siswanta, D., and Mudasir. 2016. Preparation of citric acid crosslinked chitosan/poly(vinyl alcohol) blend membranes for creatinine transport. Indo. J. Chem., 16, 144–150.

Miya, M., Yoshikawa, S., Iwamoto, R., and Mima, S. 1983. Mechanical properties of poly(vinyl alcohol)-chitosan blend films. Kobunshi Ronbunshu. 645–651.

Park, J.S., Park, J.W., and Ruckenstein, E. 2001. Thermal and dynamic mechanical analysis of PVA/MC blend hydrogels. Polymer., 42, 4271–4280.

Rashidova, S.S., Milusheva, R.Y., Semenova, L.N., Mukhamedjanova, M.Y., and Voropaeva, N.L. 2004. Characteristics of interactions in the pectin-chitosan system. Chromatographia., 59, 779–782.

Richert, L., Boulmedais, F., Lavalle, P., Mutterer, J., and Ferreux, E. 2004. Improvement of stability and cell adhesion properties of polyelectrolyte multilayer films by chemical cross-linking. Biomacromolecules., 5, 284–294.

Sagnella, S., and Mai-Ngam, K. 2005. Chitosan based surfactant polymers designed to improve blood compatibility on biomaterials. Colloids Surf., B., 42, 147–155.

DOI: https://doi.org/10.22146/ijbiotech.25812