Evaluation of the Antiplasmodial Properties of Andrographis paniculata (Burm.f.) and Peperomia pellucida (L.) Kunth
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| 1. | Title | Title of document | Evaluation of the Antiplasmodial Properties of Andrographis paniculata (Burm.f.) and Peperomia pellucida (L.) Kunth |
| 2. | Creator | Author's name, affiliation, country | Nurhayati Bialangi; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Gorontalo, Gorontalo 96128, Indonesia; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Mohamad Adam Mustapa; Department of Pharmacy, Faculty of Sport and Health Sciences, Universitas Negeri Gorontalo, Gorontalo 96128, Indonesia; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Yuszda Salimi; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Gorontalo, Gorontalo 96128, Indonesia; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Weny Musa; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Gorontalo, Gorontalo 96128, Indonesia; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Ari Widiyantoro; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Tanjungpura, Pontianak 78115, Indonesia; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Agus Malik Ibrahim; Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten, 42411, Indonesia; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Boima Situmeang; Department of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten, 42411, Indonesia; Indonesia |
| 2. | Creator | Author's name, affiliation, country | Julinton Sianturi; Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14424 Potsdam, Germany; Germany |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | A. paniculata (Burm.f.); P. pellucida L. Kunth; Plasmodium falciparum; inhibition; 3β-hydroxy-9-lanosta-7,24E-dien-26-oic acid |
| 4. | Description | Abstract | Plasmodium species are the infectious agents that are responsible for malaria, a disease that claims the lives of approximately 400,000 people annually. The fact that drug resistance against malaria is on the rise suggests that new antimalarial compounds need to be discovered. It is well known that medicinal plants present the best opportunity for the identification of novel antimalaria chemicals. Both the Andrographis paniculata (Burm.f.) and Peperomia pellucida (L. Kunth) species have been tested for their antiplasmodial ability against the Plasmodium falciparum strain. The P. pellucida (L. Kunth) species has also been subjected to in vitro and in vivo biological research. P. pellucida was used to isolate the steroid known as 3-hydroxy-24-ethyl-5,22-cholestadiene (1) and the triterpenoid known as 3-hydroxy-9-lanosta-7,24E-dien-26-oic acid (2). Both compounds were then tested for their activity in vitro. In the mice model, triterpenoid 2 had a substantial chemo-suppressive impact. |
| 5. | Publisher | Organizing agency, location | Universitas Gadjah Mada |
| 6. | Contributor | Sponsor(s) | Directorate General of Higher Education, Ministry of Research, Technology and Higher Education, Indonesia |
| 7. | Date | (YYYY-MM-DD) | 2022-12-07 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | Full Text PDF, Full Text PDF-Suppl. Data |
| 10. | Identifier | Uniform Resource Identifier | https://journal.ugm.ac.id/ijc/article/view/74481 |
| 10. | Identifier | Digital Object Identifier (DOI) | https://doi.org/10.22146/ijc.74481 |
| 11. | Source | Title; vol., no. (year) | Indonesian Journal of Chemistry; Vol 23, No 1 (2023) |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files |
supporting information (3MB) |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2022 Indonesian Journal of Chemistry This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |