Maximum Tolerated Volume in Nutrient Drinking Test for Diagnosis of Functional Dyspepsia

Suharjo Broto Cahyono(1*), Neneng Ratnasari(2), Putut Bayupurnama(3), Siti Nurdjanah(4)

(*) Corresponding Author


Background. Methods to evaluate pathophysiology of functional dyspepsia (FD) such as barostat are invasive, expensive and not readily available. Nutrient drink test was developed as noninvasive, safe and low cost means to assess impaired gastric accommodation in FD patients. The aim of this study is to evaluate whether this test could be used for diagnostic tool for FD patients.

Method. A cross sectional study was conducted from July 2014 to December 2014, at Sardjito General Hospital, Yogyakarta, Indonesia. Twenty FD patients (according Rome III criteria with normal gastroscopy) were matched by age, gender and body mass index with 20 healthy controls. All of FD patient and healthy controls ingested nutrient drink tests (UltraMilk contain 0.6 kcal /mL). Maximum tolerated volume (MTV) of each subject was recorded. Sensitivity, specifi city, positive predictive value (PPV) and negative predictive value (NPV) were analyzed.Results. Using ≤ 950 mL of maximum tolerated volume as cut off point, sensitivity, specificity, PPV and NPV were 95%, 100%, 100% and 95%.

Conclusions. A nutrient drinking test can discriminate between FD patients and healthy controls with high sensitivity and specifi city. This test could be used as objective, safe and non-invasive diagnostic tool for FD patients.


nutrient drink test, impaired gastric accommodation, functional dyspepsia, diagnostic test

Full Text:



Tack, T. , R a f, B., Giovanni, S. Pathophysiology and treatment of functional dyspepsia. Gastroenterology 2004;

: 1239 – 1255

Geeraerts B., Tack J. Functional dyspepsia: past, present and future. J Gastroenterology 2008; 43: 251 – 255

Bun, R., Braden, K. Functional dyspepsia. Therapeutic Advances in Gastroenterology: 2010; 145 – 164

Van Den Elzen B., Boeckxstaens G. Review article: a critical view on impaired accommodation as therapeutic target for functional dyspepsia. Aliment Pharmacol Ther 2006; 23: 1499 – 1510

Park M. How to interpret nutrition drink test? J Neuro gastroenterology Motil 2011; 17: 88 – 90

Bolino MC., Furia M., Facio L., et al. Functional dyspepsia and the satiety test: its usefulness in clinical practice. Rev Gastro de Mexico 2013; 78: 127 – 134

Chial, H.J., Camilleri, C., Delgado, A., Burton, D., Thomforde, G., et al. A nutrient drink test to assess maximum tolerated volume and postprandial symptoms: effects of gender, body mass index and age in health. Neuro-gastroenterol Mot 2002; 14: 249 – 253

De Schepper, H.U., Cremonini, F., Chitkara, D., Camilleri, M. Assessment of gastric accommodation: overview and evaluation of current methods. Neurogastroenterol Motil 2004; 16: 275 – 285

Loza A., Schmulson M., Gomez S., Troche J., Diaz M. Maximum tolerated volume in drinking tests with water and a nutritional beverage for the diagnosis of functional dyspepsia. World J Gatroenterology 2005; 11: 3122 – 3126

Hjelland, I.E., Ofstad, A.P., Narvestad, J.K, et al. Drink tests in functional dyspepsia: which drink is best? Scan J Gastroenterol 2004; 10: 933 – 937

Jones, M.P. Satiety testing: ready for the clinic? World J Gastroenterology 2008; 14: 5371 – 5376

Boeckxstaens, G.E., Hirsch, D.P., Van den Elzen, B.D., Heisterkamp, S.H., Tytgat, G.N. Impaired drinking capacity in patients with functional dyspepsia: relationship with proximal stomach function. Gastroenterology 2001; 121: 1054 – 1063


Article Metrics

Abstract views : 1024 | views : 687


  • There are currently no refbacks.

Copyright (c) 2017 Acta Interna The Journal of Internal Medicine

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Acta Interna The Journal of Internal Medicine Indexed by:


 Indonesia Onesearch Google Scholar IPI Indonesian Publication Index

 website statistics View My Stats  



Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.