The effects of albumin concentration to outcome of acute respiratory distress syndrome (ARDS) patients in intensive care unit RSUP Dr. Sardjito Yogyakarta

Novia Etty Parmawati(1*)

(*) Corresponding Author


Background: Hipoproteinemia mostly happened in critically ill patients, including ARDS, and usually comes to
worst clinical appearance. Early ARDS is characterized by a rising of the permeability in the alveolar-capillary
barrier, leading to an infl ux of fl uid into the alveoli, and albumin also has a major role to control the osmolatory
of plasma.
Aim: The aim of the study was to know about the effect of the albumin concentration to outcome (survivor/nonsurvivor) of the ARDS patient in the Intensive Care Unit (ICU) RSUP Dr. Sardjito.
Methods: This study used cross-sectional method. The samples of this study were the patients at the ICU RSUP
Dr. Sardjito Yogyakarta, from January 2009 until December 2011. The diagnosed of ARDS based on EACC
criteria. The inclusion criteria were people with age ≥ 18 years old, fulfi ll diagnostic criteria of ARDS, and treated
in ICU. The demography, laboratory result, and curing process, have been tested statistically in SPSS 17. The
variable was analyzed by chi-square and Mann-Whitney test, signifi cantly considered if p < 0,05.
Results: The samples who fulfi ll these criteria were 61 patients. Mostly women (54,1%) with 49 years-old range
and the result were 34 patients (55,7%) died. The biggest cause of ARDS was pneumonia (60,7 %) and the
biggest Comorbid was malignant (21,6%). The mortality rate of ARDS was 5,75%. The result of univariat analysis
was the increased of transaminase enzyme (p 0,007), COPD Co morbid (p 0, 02) and length of stay in the ICU (p
= 0,021) which was signifi cantly given effect to the outcome of the patients. The survivors have higher albumin
concentration (2, 6) than in non survivors (2, 4), although not statistically signifi cant (p = 0,621).
Conclusion:The albumin concentration did not have a statistically signifi cant effect to the outcome of the ARDS
patient in ICU RSUP Dr. Sardjito Yogyakarta. The main factor was the increase of transaminase enzyme, Co
morbid COPD, and length of stay in the ICU.
Keywords: ARDS, albumin concentration, ICU



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