The effects of albumin concentration to outcome of acute respiratory distress syndrome (ARDS) patients in intensive care unit RSUP Dr. Sardjito Yogyakarta

Novia Etty Parmawati

doi:10.22146/acta interna.5001

The effects of albumin concentration to outcome of acute respiratory distress syndrome (ARDS) patients in intensive care unit RSUP Dr. Sardjito Yogyakarta

https://doi.org/10.22146/acta%20interna.5001

Novia Etty Parmawati^(1*)

(1)
(*) Corresponding Author

Abstract

ABSTRACT
Background: Hipoproteinemia mostly happened in critically ill patients, including ARDS, and usually comes to
worst clinical appearance. Early ARDS is characterized by a rising of the permeability in the alveolar-capillary
barrier, leading to an infl ux of fl uid into the alveoli, and albumin also has a major role to control the osmolatory
of plasma.
Aim: The aim of the study was to know about the effect of the albumin concentration to outcome (survivor/nonsurvivor) of the ARDS patient in the Intensive Care Unit (ICU) RSUP Dr. Sardjito.
Methods: This study used cross-sectional method. The samples of this study were the patients at the ICU RSUP
Dr. Sardjito Yogyakarta, from January 2009 until December 2011. The diagnosed of ARDS based on EACC
criteria. The inclusion criteria were people with age ≥ 18 years old, fulfi ll diagnostic criteria of ARDS, and treated
in ICU. The demography, laboratory result, and curing process, have been tested statistically in SPSS 17. The
variable was analyzed by chi-square and Mann-Whitney test, signifi cantly considered if p < 0,05.
Results: The samples who fulfi ll these criteria were 61 patients. Mostly women (54,1%) with 49 years-old range
and the result were 34 patients (55,7%) died. The biggest cause of ARDS was pneumonia (60,7 %) and the
biggest Comorbid was malignant (21,6%). The mortality rate of ARDS was 5,75%. The result of univariat analysis
was the increased of transaminase enzyme (p 0,007), COPD Co morbid (p 0, 02) and length of stay in the ICU (p
= 0,021) which was signifi cantly given effect to the outcome of the patients. The survivors have higher albumin
concentration (2, 6) than in non survivors (2, 4), although not statistically signifi cant (p = 0,621).
Conclusion:The albumin concentration did not have a statistically signifi cant effect to the outcome of the ARDS
patient in ICU RSUP Dr. Sardjito Yogyakarta. The main factor was the increase of transaminase enzyme, Co
morbid COPD, and length of stay in the ICU.
Keywords: ARDS, albumin concentration, ICU

References

REFERENCES

Bhadade, R.R., de Saouza, R.A., Harde, M.J., Khot, A. 2011. Clinical characteristic and outcome of patients with acute lung injury and acute respiratory distress syndrome in Topiwala National Medical College Journals Vol 57:286-290. Mumbai.

Bourdon, E. and Blache, D. (2001) The importance of proteins in defense against oxidation. Antioxid. Redox Signal. 3, 293–311.

Deng, W., Yu, M., Ma, H., Hu L.A., Chen, G., Wang, Y., Deng, J., Li,C.Y., Tong, J., Wang, D.X.2012. Predictors and outcome of patients with acute respiratory distress syndrome caused by miliary tuberculosis: a retrospective study in Chongqing, China. BMC Infectious Diseases 2012, 12:121.

Jia,X., Malhotra,A., Saeed,M., Mark,R.G., Talmor, D.2008. Risk Faktors for ARDS in Patients Receiving Mechanical Ventilation for > 48 h*. Chest

Journal.133 : 853-61.

Khan, A, Milbrandt, E.B.,Venkataraman, R. 2007. Albumin and furosemide for acute lung injury. Journal club critique. Critical Care 2007, 11: 314 (DOI 10.1186/cc).

Lin, Chan-Yu., Kao, Kuo-Chin., Tian, Ya-Chung., Jenq, Chang-Chyi., Chang. Ming-Yang. 2009. The RIFLE Score Increases the Accuracy of OutcomePrediction in Patients with Acute Respiratory Distress Syndrome Undergoing Open Lung Biopsy in Respiration 77:398-406.

Mangialardi RJ, Martin, G.S., Bernard, G., Wheeler AP, Arthur, P., Christman, B.W., et al. 2000. Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Crit Care Med. Vol 28. Pp 3137-45.

Martin, G.S. 2000. Fluid balance and colloid osmotic pressure in acute respiratory failure: emerging clinical evidence. Critical Care 2000, 4(Suppl 2):S21-S25.

Martin GS, Mangialardi RJ, Wheeler AP, Dupont WD, Morris JA, Bernard GR. 2002. Albumin and furosemide therapy in hypoproteinemic patients

with acute lung injury. Crit Care Med, 30:2175- 2182.

Monchi, M., Bellenfant, F., Cariou, A., Joly, L., Thebert, D., Laurent, I., Dhainaut, J., Brunet, F. 1998. A Multivariate analysis-Early predictive factors of survival in the acute respiratory distress syndrome in Am J Respir Crit Care Med 158:1076-1061.

Nicholson, J.P., Wolmarans, M.R., Park, G.R. 2010. The Role of albumin in Critical Illness. British journal of Anaesthesia b5 (4) : 599-610.

Roche, M., Rondeau, P., Singh, n.R., Tarnus, E.,Bourdon, E. 2008. Minireview : The antioxidant properties of serum albumin. FEBS Letters 582 : 1783–178.

Williams, T.A., Dobb, G.J., Finn, J.C. Knuiman, M. 2010. Effect of length of stay in intensive care unit on hospital and long-term mortality of critically ill adult patients, British Journal of Anaesthesia 104 (4): 459–64

Wingfi eld, W.E.: Fluid and electrolyte therapy, in Wingfield WE, Raffe MR (eds): The Veterinary ICU Book. Jackson, WY, Teton New Media. 2002. pp 166–188.

DOI: https://doi.org/10.22146/acta%20interna.5001