Correlation Between Tp-Te Interval With the Degree of Disfunction in Liver Cirrhosis Based on Child Pugh Turcotte Score in Dr. Sardjito General Hospital
RA Aditya Adhi Puruhita(1*), Hasanah Mumpuni(2), Neneng Ratnasari(3)
(1) 
(2) 
(3) 
(*) Corresponding Author
Abstract
Background. Hyperdynamic syndrome due to portal hypertension in cirrhosis of the liver leads to failure of
contractions and cardiac structures that result in complications of cardiomyopathy cirrhosis. The incidence
of arrhythmias was reported in various non- cardiac diseases including liver cirrhosis. We aim to evaluate
the T peak wave - T end (Tp-Te) as a parameter for suspected arrhythmias that occur in liver cirrhosis.
Aims. To determine the correlation between the Tp-Te interval with dysfunction in the degree of liver
cirrhosis, which was assessed using the Child Pugh Turcotte score.
Methods. This research is a cross-sectional study. Data taken from liver cirrhosis patients who has been met
the inclusion and exclusion criteria were admitted to the Inpatient and Outpatient Hospital Dr. Sardjito until
May 2020, an assessment of the degree of dysfunction of liver cirrhosis with Child Pugh score Turcotte, and
electrocardiographic examination to assess Tp-Te wave. The independent variable was the Child Pugh Turcotte
score, the dependent variable was the Tp-Te wavelength. Analysis of correlation data using the Spearman test.
Results. Subjects included 51 patients with liver cirrhosis, correlation analysis found a strong correlation,
the higher the Child Pugh Turcotte score was linearly correlated with the Tp-Te wavelength (r = 0.692; p
<0.05). Wavelength Tp-Te at Child Pugh to any group showed a significant (p <0.001) , the wavelength
of Tp-Te Child Pugh A group 67.94 ± 7.80 ms, the Child Pugh B group 77.26 ± 8.38 ms, whereas in
the Child Pugh C group 92.31 ± 11.36 ms.
Conclusion. There was a strong positive correlation between the Tp-Te interval with the degree of liver
cirrhosis dysfunction which was assessed using the Child Pugh Turcotte score.
Keywords
Full Text:
PDFReferences
Nurdjanah S. Liver cirrhosis. In: Sudoyo AW, Setiyohadi B, Alwi I, editors. Books teach the science of medicine. 4th ed. Jakarta: FKUI Internal Medicine Publishing Center; 2006. p. 443-6 2. Sulaiman, Akbar, Lesmana and Noer. 2007. Book Festive Studies of Liver Diseases . Jakarta: Jayabadi 3. Bacon BR. Cirrhosis and complications. In: Longo DL, Fauci AS, editors. Harrison's gastroenterology and hepatology. Jakarta: EGC; 2010 .p. 374-86. 4. Fede G, Privitera G, Tomaselli T, Spadaro L, Purrello F. Cardiovascular dysfunction in patients with liver cirrhosis. Ann Gastroenterol. 2014; 27 (5): 1-10. 5. Wiese S, Hove JD, Bendtsen F, Møller S. Cirrhotic cardiomyopathy: Pathogenesis and clinical relevance. Nat Rev Gastroenterol Hepatol. 2014; 11: 177-86. doi : 10.1038 nrgastro.2013.210. 6.Dumont CA, Monserrat L, Soler R, Rodríguez E, Fernandez X, Peteiro J, Bouzas A, Bouzas B, Castro-Beiras A. Interpretation of electrocardiographic abnormalities in hypertrophic cardiomyopathy with cardiac magnetic resonance. European heart journal. 2006 Jun14 ; 27 (14): 1725-31. 7. Mozos, Ioana. "Arrhythmia risk in liver cirrhosis." World journal of hepatology 7.4 (2015): 662. 8. Karaagac K, Emul A, Tenekecioglu E, Agca FV, Ozluk OA, Tutuncu A, Yontar OC, Yilmaz M. The Effects of Metabolic Syndrome on TpTe Interval and TpTe / QT Ratio in Patients with Normal Coronary Arteries. The Eurasian journal of medicine. 2014 Oct ; 46 (3): 182. 9. Salgado AA, Barbosa PR, Ferreira AG, Reis CA, Terra C. Prognostic Value of a New Marker of Ventricular Repolarization in Cirrhotic Patients. Arquivos brasileiros de cardiologia. 2016 Dec ; 107 (6): 523-31. 10. Scaglione, Steven, et al . "The epidemiology of cirrhosis in the United States." Journal of clinical gastroenterology 49.8 (2015): 690-696. 11. Chou R, Wasson N. Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: a systematic review. Ann Intern Med. 2013 ; 158: 807 -20. 12. Lanzieri, PG, Gismondi, RA, Chimelli, MDCAR, Cysne, RP, Guaraná, T., Mesquita, CT, & Mocarzel, LO (2017). Cirrhotic patients with Child-Pugh C have longer QT intervals. International Journal of Cardiovascular Sciences , 30 (6), 496-503. 13. Viitasalo, Matti, et al . "Effects of beta-blocker therapy on ventricular repolarization documented by 24-h electrocardiography in patients with type 1 long-QT syndrome." Journal of the American College of Cardiology 48.4 (2006): 747-753.
DOI: https://doi.org/10.22146/actainterna.62843
Article Metrics
Abstract views : 2031 | views : 912Refbacks
- There are currently no refbacks.
Copyright (c) 2021 Acta Interna: The Journal of Internal Medicine
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Acta Interna The Journal of Internal Medicine Indexed by:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.