Pengaruh suplementasi tablet fe mingguan dan harian terhadap kepatuhan minum tablet Fe dan perubahan kadar hemoglobin pada ibu hamil di Kabupaten Bantul Yogyakarta

Dwi Susetyo(1*), Mohammad Hakimi(2), Hamam Hadi(3)

(1) Politeknik Kesehatan Semarang
(2) Bagian Kebidanan dan Penyakit Kandungan RSUP Dr. Sardjito Yogyakarta/Fakultas Kedokteran Universitas Gadjah Mada
(3) Magister Gizi dan Kesehatan, Fakultas Kedokteran Universitas Gadjah Mada
(*) Corresponding Author


Background: In Indonesia, in 1995, 50.9% pregnant women suffer from Iron Deficiency Anemia (IDA).

Objective: To compare the effect of weekly iron/folate vs standard daily iron/folate supplementation in pregnant women on compliance and hemoglobin level.

Methods: The study was a quasi-experimental, non-equivalent control group design. Pregnant women with 20-28 week gestation were enrolled in this study in Bantul District. They were divided into two groups. One group (n=70), in Pajangan and Sewon Sub District, was given 120 mg iron/0,50 mg folate once a week, and the second group (n=65), in Bambang Lipuro and Pundong Sub District, received 60 mg iron/0,25 mg folate per day. Compliance with supplementation was assessed by the women self-reporting, pill count, and stool test. To measure hemoglobin level, the cyanmethemoglobin method was conducted.

Results: Compliance was significantly higher in the weekly group (84.69% compared with 71.94%, p=0,004). A multiple logistic regression analysis indicated odds ratio 6.605, it means that in the weekly group compliance was 6,6 times higher than in the daily group. Hemoglobin level increased in both groups. There was no significant difference between groups for changes in hemoglobin. Initial haemoglobin values for the weekly (m=11.61 g/dl) and daily (m=11.27 g/dl) groups as well as final hemoglobin values (11.99 g/dl and 11.83 g/dl, respectively) did not differ significantly between the two groups.

Conclusion: Supplementation on a weekly basis is as effective as daily supplementation in improving iron status in pregnant women. In the weekly group, compliance can be ensured.


iron supplementation; hemoglobin level; compliance; pregnant women

Full Text:



Yip R. Iron Deficiency: Contemporary Scientific Issues And International Programmatic Approaches. J Nutr 1994;124 (Suppl):1479S-90S.

Depkes. Program Perbaikan Gizi Menuju Indonesia Sehat 2010. Jakarta: Direktorat Jenderal Bina Kesehatan Masyarakat; 2000.

Ridwan E, Schultink W, Dillon D, Gross R. Effects Of Weekly Iron Supplementation On Pregnant Indonesian Women Are Similar To Those Of Daily Supple-mentation. Am J Clin Nutr 1996;63:884-90.

Saidin M, Sukati S, Martuti S. Efektivitas Suplementasi Pil Zat besi Dua Kali Seminggu dan Satu Kali Sehari Pada Ibu Hamil. Penelitian Gizi dan Makanan 1997;20.

Young MW, Lupatya E, Kapenda E, Bobrow EA. The Effectiveness of Weekly Iron Supplementation in Pregnant Women of Rural Northern Malawi. Tropi-cal Doctor 2000;30:84–88

Muslimatun S, Schmidt MK, Schultink W, West CE, Hautvast JGAJ, Gross R, Muhilal. Weekly Supplementation with Iron and Vitamin A during Pregnancy Increases Hemoglobin Concentration but Decreases Serum Ferritin Concentration in Indonesian Pregnant Women. Am Soc for Nutr Sci 2000;1:85-70.

Yip R. Iron Supplementation During Pregnancy: Is it effective?. Am J Clin Nutr 1996;63:853-55.

Schultink W, Ree MVD, Matulessi P, Gross R. Low Compliance With an Iron-Supplementation Program: a Study among Pregnant Women in Jakarta, Indo-nesia. Am J Clin Nutr 1993;57:135-39.

Galloway R, McGuire J.Determinants of Compliance with Iron Supplementation: Supplies, Side Effects, or Psychology? Soc Sci Med 1994;39(3):381-90.

Bread JL. Weekly Iron Invervention: the Case for In-termittent Iron Supplementation. Am J Clin Nutr 2000;71:1288S-94S.

US Preventive Services Task Force. Routine Iron Supplementation during Pregnancy, Policy Statement. JAMA 270 1993;23:2846-54.

Hallberg L. Combating Iron Deficiency: Daily Admin-istration Of Iron Is Far Superior To Weekly Adminis-tration. Am J Clin Nutr 1998;68:213-7.

Gross R, Schultink W, Juliawati. Treatment of Anaemia with Weekly Iron Supplementation. Lancet 1994;344.


Article Metrics

Abstract views : 2743 | views : 2699


  • There are currently no refbacks.

Copyright (c) 2016 Jurnal Gizi Klinik Indonesia (The Indonesian Journal of Clinical Nutrition)

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Gizi Klinik Indonesia (JGKI) Indexed by:

web stats View My Stats