Kejadian mikropenis pada anak obes

https://doi.org/10.22146/ijcn.17681

Siswanto Basuki(1*), Madarina Julia(2), Soeroyo Machfudz(3)

(1) RS dr. Soeroto Ngawi
(2) Bagian Anak RSUP Dr. Sardjito
(3) Bagian Anak RSUP Dr. Sardjito
(*) Corresponding Author

Abstract


Background : Obese children are more likely to have less testosterone, which may lead to disorder of penile development.

Objectives : To assess the association between obesity in children and the occurrence of micropenis. 

Methods : TA cross sectional study was carried out in 36 obese and 28 non- obese pubertal male children (10-13 years old) and 49 obese and 36 non-obese prepubertal male children (4-7 years old). Obesity was defined as body mass index (BMI) equivalent to or above the 95th percentile of the CDC 2000 growth reference standard. Length of the penis was measured perpendicular to the surface of the os symphysis pubis to the tip of the glans penis. Skinfold thickness was measured on the area of mons pubis using a caliper. Volume of the testis was measured using an orchidometer. 

Results : The mean (SD) of penis length in 36 pubertal obese and 28 non-obese children were 5.56 (1.14) cm and 6.05 (1.37) cm, respectively; whereas the mean (SD) of penis length in 49 pre-pubertal obese and 39 non-obese children were 5.09 (0.76) cm and 5.36 (0.56) cm, respectively. There was significant difference in the mean (95% CI) length of penis in pubertal obese and non-obese children (p = 0.04). Fisher's exact test showed that the occurrence of micropenis was not associated with obesity, age, fat thickness on mons pubis, and volume of the testicles.

Conclusion : There was no significant difference in the occurrence of micropenis, but there was significant difference in the mean length of penis in obese children and children with normal age-related body mass index. 


Keywords


penis length; obesity; micropenis

Full Text:

PDF


References

World Health Organization. Obesity: Preventing and Managing The Global Epidemic. Geneva: World Health Organization; 2000. Technical Report Series 894.

Satoto, Karjati S, Darmojo B, Tjokroprawiro A, Kodyat BA. Kegemukan, Obesitas dan Penyakit Degeneratif: Epidemiologi dan Strategi Penanggulangannya. Prosiding Widyakarya Nasional Pangan dan Gizi VI; 1998; Jakarta, Indonesia. Jakarta: LIPI; 1998. p. 787–808.

MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK. Origin of Estrogen in Normal Men and in Women with Testicular Feminization. J Clin Endocrinol Metab 1979;49:905-16.

Zenaty D, Dijoud F, Morel Y, Carrol S, Mouriquand P, Nicolno P, et al. Bilateral Anorchia in Infancy: Occurrence of Micropenis and The Effect at Testosteron Treat-ment. J Pediatr 2006;149:687-91.

Ohia E. Neurobiology of Obesity. In: Petit W, Adamec CA, editors. The Encyclopedia of Endocrine Diseases and Disorders. New York: Facts on File Inc; 2005.

Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum Immunoreactive Leptin Concentrations in Normal Weight and Obese Humans. N Engl J med 1996;334(5):292-5.

Isidori AM, Caprio M, Strollo P, Moretti C, Projese G, Ishidori A, et al. Leptin and Androgens in Male Obesity: Evidence for Leptin Contribution to Reduced Androgen Levels. J Clin Endocrinol Metab 1999;84: 3673-80.

Guyton A, Hall W. Textbook of Medical Physiology. 7th ed. USA: William & Sanders; 2000.

Lemeshow S, Hosmer D, Klar J. 1990. Adequacy of Sample Size in Health Studies. (Terjemahan) Pramono D. Yogyakarta: UGM Press; 1997.

CDC. CDC Growth Charts for the United States: Meth-ods and Development. Washington DC: DHHS Publication; 2002.

Gabrich PN, Vasconcelos JS, Damião R, da Silva EA. Penile Anthropometry in Brazilian Children and Adolescents. J Pediatr (Rio J) 2007; 83(5):441-6.

Herman ME, Giddens PA, Wang L, Koch G. Estimates From the National Health and Nutrition Examination Survey III, 1988-1994, Secondary Sexual Characteristics in Boys. Arch Pediatr Adolesc Med 2001;155:1022-8.

Hill M. Development of the Genital System. Sydney, Australia: School of Medical Sciences, Faculty of Medicine, The University of New South Wales; 2007.

Hurlock E. Development Psychology. Tokyo: McGraw-Hill Kogakusha; 2000.

Lee PA, Guo SS, Kulin HE. Age of Puberty: Data from United States of America. APMIS 2001;109:81-8.

Rosner B, Prineas R, Loggie D, Daniel S. Percentile for Body Mass Index in US Children 5 to 17 Years of Age. J Pediatr 1998;132:211-22.

Aygun AD, Gungor S, Ustundag B, Gurgoze MK, Sen Y. Proinflamatory Cytokine an leptin Are Increased in Serum at Prepubertal obese Children. Mediators and inflammation 2005;3:180-3.

MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK. Origin of Estrogen in Normal Men and in Women with Testicular Feminization. J Clin Endocrinol Metab 1979;49:905-16.

Poncheitti R, Mondaini N, Bonate M, Di Loro F, Biscioni S, Masieri Z. Penile Length and Circumference: A. Study on 3300 young Italian Males. Eur Urol 2001;39:183-6.



DOI: https://doi.org/10.22146/ijcn.17681

Article Metrics

Abstract views : 3432 | views : 7037

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 Jurnal Gizi Klinik Indonesia (The Indonesian Journal of Clinical Nutrition)

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Gizi Klinik Indonesia (JGKI) Indexed by:
 
  

  free
web stats View My Stats