Evaluation of Antihypertension Drugs on Patients Diabetes Mellitus in RSI Sultan Agung Semarang 2016


Dian Oktianti(1*), Nurul Fitria Dewi(2), Meiji Pujiawati(3)

(1) Study Program of Pharmacy, Ngudi Waluyo University
(2) Study Program of Pharmacy, Ngudi Waluyo University
(3) Study Program of Pharmacy, Ngudi Waluyo University
(*) Corresponding Author


More than 50% of patients with type 2 diabetes mellitus are associated with hypertension. Uncontrolled blood pressure in patients with type 2 diabetes mellitus correlated with the onset of cardiovascular and cerebrovascular complications. Therefore, proper blood pressure management is needed to delay and prevent complications. Selection of appropriate antihypertensive drugs along with appropriate doses is one way to inhibit the possibility of complications. The purpose of this study is to know about the accuracy of the use of antihypertensive drugs and doses used. This research is a descriptive and observational retrospective research. The subjects of the study were 88 patients with diabetes mellitus with accompanying hypertension. Data taken include antihypertensive, antidiabetes mellitus, laboratory data. The data obtained are then analyzed descriptively using JNC edition 8 and DIH 2015. The results showed that there were 88 samples meeting the inclusion and exclusion criteria. The commonly used single antihypertensive group is Angiotensin Receptor Blocker (ARB) of 56.09%, and antihypertensive combination is Angiotensin Receptor Blocker (ARB) - Calsium Chanel Blocker (CCB) of 65.95%. Based on the results of analysis, the results obtained for the right drug and the patient is 98.86% and for the accuracy of the dose obtained 97.72%.


Diabetes mellitus type 2; hypertension; antihypertensive; right medication; right patient; dose accuracy

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Armstrong, C., 2014. JNC8 Guidelines for the Management of Hypertension in Adults. American Family Physician, 90: 503–504.

Barzilay, J.I., Peterson, D., Cushman, M., Heckbert, S.R., Cao, J.J., Blaum, C., dkk., 2004. The relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: the cardiovascular health study. American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation, 44: 25–34.

Chentli, F., Azzoug, S., dan Mahgoun, S., 2015. Diabetes mellitus in elderly. Indian Journal of Endocrinology and Metabolism, 19: 744–752.

Creatore, M.I., Moineddin, R., Booth, G., Manuel, D.H., DesMeules, M., McDermott, S., dkk., 2010. Age- and sex-related prevalence of diabetes mellitus among immigrants to Ontario, Canada. Canadian Medical Association Journal, 182: 781–789.

Cryer, M.J., Horani, T., DiPette DJ, 2016, Diabtes and Hypertension: A comparative review of current guideline, J Clin hypertens, 18: 95-100.

Dahlan, M.S., 2008. Statistik untuk Kedokteran dan Kesehatan, 3rd ed. Penerbit Salemba, Jakarta.

Grossman, E., Messerli, F.H., dan Goldbourt, U., 2000. High blood pressure and diabetes mellitus: are all antihypertensive drugs created equal? Archives of Internal Medicine, 160: 2447–2452.

Group, T.A.S., 2010. Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus. New England Journal of Medicine, 362: 1575–1585.

Ho, K.M. dan Sheridan, D.J., 2006. Meta-analysis of frusemide to prevent or treat acute renal failure. BMJ, 333: 420.

'IDF diabetes atlas - 2015 Atlas', n.d. URL: http://www.diabetesatlas.org/resources/2015-atlas.html (diakses tanggal 29/10/2017).

Johnson, M.L. dan Singh, H., 2005. Patterns of antihypertensive therapy among patients with diabetes. Journal of General Internal Medicine, 20: 842–846.

Kacerovsky-Bielesz, G., Lienhardt, S., Hagenhofer, M., Kacerovsky, M., Forster, E., Roth, R., dkk., 2009. Sex-related psychological effects on metabolic control in type 2 diabetes mellitus. Diabetologia, 52: 781–788.

Kalra, S., Kalra, B., dan Agrawal, N., 2010. Combination therapy in hypertension: An update. Diabetology & Metabolic Syndrome, 2: 44.

Lacy CF; Amstrong LL; Goldman MP and Lance LL. 2015. Drug Information Handbook. 24th ed. Lexi-Comp for the American Pharmacists Association. United States.

Mallat, S.G., Itani, H.S., dan Tanios, B.Y., 2013. Current perspectives on combination therapy in the management of hypertension. Integrated Blood Pressure Control, 6: 69–78.

Sever, P.S. dan Messerli, F.H., 2011. Hypertension management 2011: optimal combination therapy. European Heart Journal, 32: 2499–2506.

Suzuki, K., Souda, S., Ikarashi, T., Kaneko, S., Nakagawa, O., dan Aizawa, Y., 2002. Renoprotective effects of low-dose valsartan in type 2 diabetic patients with diabetic nephropathy. Diabetes Research and Clinical Practice, 57: 179–183.

Ucan, O. dan Ovayolu, N., 2010. Relationship between diabetes mellitus, hypertension and obesity, and health-related quality of life in Gaziantep, a central south-eastern city in Turkey. Journal of Clinical Nursing, 19: 2511–2519.

Vijan, S. dan Hayward, R.A., 2003. Treatment of hypertension in type 2 diabetes mellitus: blood pressure goals, choice of agents, and setting priorities in diabetes care. Annals of Internal Medicine, 138: 593–602.

DOI: https://doi.org/10.22146/jmpf.33342

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