Clinical and therapeutic characteristics of hospitalized cancer patients in the Najran Region of Saudi Arabia: a cross-sectional study

https://doi.org/10.22146/jmpf.78654

Hamad S Alyami(1*), Abdallah Y Naser(2), Mohammad H. Alyami(3), Ibraheem S. Banihameem(4), Mohammad Almusabi(5), Ahlam M. Alqahtani(6), Mohammed A. Gannas(7), Hadi S. Alyami(8), Hadi J. Al Sulayyim(9), Saeed F. Alkorbi(10), Hussain M. Alsagoor(11), Abdullah M. Alyami(12), Rubiaan S. Almadi(13), Salem Hussain Alharethi(14)

(1) Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.
(2) Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman, Jordan.
(3) Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.
(4) General Directorate of Health Affairs Najran, Ministry of Health, Najran, Saudi Arabia
(5) King Khalid Hospital, General Directorate of Health Affairs, Najran, Ministry of Health, Saudi Arabia
(6) King Khalid Hospital, General Directorate of Health Affairs, Najran, Ministry of Health, Saudi Arabia
(7) King Khalid Hospital, General Directorate of Health Affairs, Najran, Ministry of Health, Saudi Arabia
(8) King Khalid Hospital, General Directorate of Health Affairs, Najran, Ministry of Health, Saudi Arabia
(9) General Directorate of Health Affairs Najran, Ministry of Health, Najran, Saudi Arabia
(10) College of Pharmacy, Najran University, Najran, Saudi Arabia
(11) College of Pharmacy, Najran University, Najran, Saudi Arabia
(12) College of Pharmacy, Najran University, Najran, Saudi Arabia
(13) King Faisal Specialist Hospital and Research Center, Pharmaceutical Care Division, Riyadh, Saudi Arabia
(14) Department of Biological Science, College of Arts and Science, Najran University, Najran, Saudi Arabia
(*) Corresponding Author

Abstract


There are limited studies in the Southern region of Saudi Arabia on the characteristics of hospitalised patients with cancer. The aim of this study was to explore the clinical and therapeutic characteristics of hospitalized cancer patients in the Najran Region of Saudi Arabia. A retrospective cross-sectional observational study was conducted using cancer patients’ medical records at the oncology unit in the King Khalid Hospital in Najran situated in the southern region of Saudi Arabia. Hospitalized patients’ records were extracted between 2014 and 2020. Logistic regression analysis was conducted to identify determinants of ICU admission among cancer patients. A total of 1,678 patients were involved in this study. The mean age was 52.5 (SD: 21.1) years. The average duration of stay was 8.7 days (SD: 13.4). The most commonly reported types of cancer were breast cancer, rectum cancer and colon cancer, accounting for 13.6%, 6.9%, and 6.7%, respectively. A total of 13.9% of the study participants required ICU admission. More than half (57.1%) of the patients were complaining of a moderate to severe case upon hospitalization. Older age (52.5 years and above) and the presence of comorbidities were risk factors that significantly increased the risk of ICU admission (P<.001). Patients with diabetes mellitus, hypertension, heart diseases, stroke, and kidney diseases were more likely to require ICU admissions. Patients with liver cancer were more likely to require ICU admission. Healthcare professionals should give extra care and health education for high risk cancer patients including elderly patients and those with other comorbidities to prevent complications and its associated hospitalization.


Keywords


Admission; Cancer; Hospitalised; Najran

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References

  1. Alattas M. Cancer Control Priorities and Challenges in Saudi Arabia: A Preliminary projection of Cancer Burden. Gulf J Oncolog. 2019;1(29):22-30.
  2. World Health Organization. Health topics/Cancer. 2020; https://www. who.int/health-topics/cancer#tab=tab1. Accessed October 09, 2021.
  3. M Alqarni SS. A Review of Prevalence of Obesity in Saudi Arabia. Journal of Obesity & Eating Disorders. 2016;02(02).
  4. Grosso G, Bella F, Godos J, et al. Possible role of diet in cancer: systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk. Nutr Rev. 2017;75(6):405-419.
  5. National Cancer Institute. Risk Factors for Cancer. 2020; https://www.cancer. gov/ about-cancer/ causes-prevention/ risk. Accessed October 09, 2021.
  6. Adnan Hameed H, Naser AY, Mudheher Talib N. Clinical and therapeutic characteristics and medical cost of managing cancer patients in Al-Anbar, Iraq: A cross-sectional study. Saudi Pharmaceutical Journal. 2022.
  7. Bazarbashi S, Al Eid H, Minguet J. Cancer Incidence in Saudi Arabia: 2012 Data from the Saudi Cancer Registry. Asian Pac J Cancer Prev. 2017;18(9):2437-2444.
  8. El Bcheraoui C, Basulaiman M, Wilson S, et al. Breast cancer screening in Saudi Arabia: free but almost no takers. PLoS One. 2015;10(3):e0119051.
  9. Hewitson P, Glasziou P, Watson E, Towler B, Irwig L. Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (hemoccult): an update. Am J Gastroenterol. 2008;103(6):1541-1549.
  10. lmadi M, Mosli M, Bohlega M, et al. Effect of public knowledge, attitudes, and behavior on willingness to undergo colorectal cancer screening using the health belief model. Saudi J Gastroenterol. 2015;21(2):71-77.
  11. Nelson H, Fu R, Cantor A, Pappas M, Daeges M, Humphrey L. Effectiveness of Breast Cancer Screening: Systematic Review and Meta-analysis to Update the 2009 U.S. Preventive Services Task Force Recommendation. Ann Intern Med. 2016;164(4):244-255.
  12. Sankaranarayanan R. Screening for cancer in low- and middle-income countries. Ann Glob Health. 2014;80(5):412-417.
  13. Alyami HS, Naser AY, Dahmash EZ, et al. Clinical and Therapeutic Characteristics of Cancer Patients in the Southern Region of Saudi Arabia: A Cross-Sectional Study. Int J Environ Res Public Health. 2021;18(12).
  14. World Health Organization. Global Health Estimates 2016: dis-ease burden by cause, age, sex, by country and by region, 2000–2016. 2016; https://www.who.int/healthinfo/global_burden_disease/esti-mates/en/index1. html Accessed October 09, 2021.
  15. Tu H, Wen C, Tsai S, et al. Cancer risk associated with chronic diseases and disease markers: prospective cohort study. BMJ. 2018;360(134).
  16. Wojciechowska J, Krajewski W, Bolanowski M, Kręcicki T, Zatoński T. Diabetes and Cancer: a Review of Current Knowledge. Exp Clin Endocrinol Diabetes. 2016;124(5):263-275.
  17. Grossman E, Messerli F, Boyko V, Goldbourt U. Is there an association between hypertension and cancer mortality? Am J Med. 2002;112(6):479-486.
  18. Felicetti F, Catalano M, Fortunati N. Thyroid Autoimmunity and Cancer. Front Horm Res. 2017;48:97-109.
  19. Maatela J, Aromaa A, Salmi T, Pohja M, Vuento M, Grönroos M. The risk of endometrial cancer in diabetic and hypertensive patients: a nationwide record-linkage study in Finland. Ann Chir Gynaecol Suppl. 1994;208:20-24.
  20. Raspa R, Wilson C. Calcium channel blockers in the treatment of hypertension. Am Fam Physician. 48. 1993;3(461-70).
  21. Thakur A, Wang X, Garcia-Betancourt M, Forse R. Calcium channel blockers and the incidence of breast and prostate cancer: A meta-analysis. J Clin Pharm Ther. 2018;43(4):519-529.
  22. Fumagalli C, Maurizi N, Marchionni N, Fornasari D. β-blockers: Their new life from hypertension to cancer and migraine. Pharmacol Res. 2020;151(104587).
  23. Onitilo A, Engel J, Glurich I, Stankowski R, Williams G, Doi S. Diabetes and cancer II: role of diabetes medications and influence of shared risk factors. Cancer Causes Control. 2012;23(7):991-1008.
  24. Mattiuzzi C, Lippi G. Current Cancer Epidemiology. J Epidemiol Glob Health. 2019;9(4):217-222.
  25. International Agency for Research on Cancer. Global cancer observatory - cancer fact sheets. 2020; http://gco.iarc.fr/today/fact-sheets-cancers Accessed October 09, 2021.
  26. Whiteman D, Wilson L. The fractions of cancer attributable to modifiable factors: A global review. Cancer Epidemiol. 2016;44(203-21).
  27. Henson L, Maddocks M, Evans C, Davidson M, Hicks S, Higginson I. Palliative Care and the Management of Common Distressing Symptoms in Advanced Cancer: Pain, Breathlessness, Nausea and Vomiting, and Fatigue. J Clin Oncol. 2020;38(9):905-914.
  28. Greco M, Roberto A, Corli O, et al. Quality of cancer pain management: an update of a systematic review of undertreatment of patients with cancer. J Clin Oncol. 2014;32(36):4149-4154.
  29. Naser AY, Hameed AN, Mustafa N, et al. Depression and Anxiety in Patients With Cancer: A Cross-Sectional Study. Front Psychol. 2021;12:585534.
  30. Ream E, Richardson A. Fatigue: a concept analysis. Int J Nurs Stud. 1996;33(5):519-529.
  31. Stone P, Richards M, A'Hern R, Hardy J. A study to investigate the prevalence, severity and correlates of fatigue among patients with cancer in comparison with a control group of volunteers without cancer. Ann Oncol. 2000;11(5):561-567.
  32. Carr D GL, Lawrence D, et al. . Management of Cancer Symptoms: Pain, Depression, and Fatigue : Summary. In: AHRQ Evidence Report Summaries. 2002; https://www. ncbi.nlm.nih.gov/books/NBK11961/. Accessed December 18, 2022.
  33. Bennett MI, Flemming, K., & Closs, S. J. Education in cancer pain management. Current opinion in supportive and palliative care. 2011;5(1):20-24.
  34. Azoulay E, Afessa B. The intensive care support of patients with malignancy: do everything that can be done. Intensive Care Med. 2006;32(1):3-5.
  35. Downey R. Complete Blood Count Reference Ranges from a Rural Haitian Ambulatory Care Clinic. Lab Med. 2017;48(2):e24-29.
  36. Rojko L, Megyesfalvi Z, Czibula E, et al. Longitudinal analysis of complete blood count parameters in advanced-stage lung cancer patients. Thorac Cancer. 2020;11(11):3193-3204.
  37. Zhang L, Ye J, Luo Q, et al. Prediction of Poor Outcomes in Patients with Colorectal Cancer: Elevated Preoperative Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT). Cancer Manag Res. 2020;12:5373-5384.
  38. Nowak M, Lee S, Karbach U, Pfaff H, Groß S. Short length of stay and the discharge process: Preparing breast cancer patients appropriately. Patient Educ Couns. 2019;102(12):2318-2324.



DOI: https://doi.org/10.22146/jmpf.78654

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