Pengaruh Pemberian Ekstrak Etanol Kulit Buah Jeruk Baby (Citrus sinensis L. Osbeck) Selama 28 hari terhadap Kadar SGOT dan SGPT

https://doi.org/10.22146/jsv.71513

Vivi Sofia(1*), Wahyu Widyaningsih(2), Sapto Yuliani(3), Moch Saiful Bachri(4)

(1) Ahmad Dahlan University
(2) Ahmad Dahlan University
(3) Ahmad Dahlan University
(4) Ahmad Dahlan University
(*) Corresponding Author

Abstract


One of the plants used as natural medicine is baby orange (Citrus sinensis L. Osbeck). Baby oranges contain hesperidin, hesperetin, narirutin and nobiletin compounds. The purpose of this study was to determine the effect of giving ethanol extract of baby orange peel for 28 days on liver function as seen from the increase in SGOT and SGPT levels. This research is a pure experimental study with a completely randomized design (CRD) with a unidirectional pattern, namely the method used to observe the relationship of independent variables (including: normal control, negative control, ethanol extract of baby orange peel (EEKBJB) doses of 50, 100, 200 and 400 mg/kg BW) with the dependent variable (SGOT and SGPT levels). The test animals used in this study were 30 male Wistar rats which were divided into 6 treatment groups which were treated for 28 consecutive days. On day 29, blood samples were taken from the orbital sinus of the eye and the levels of SGOT and SGPT were measured. There was a significant difference in the levels of SGOT and SGPT as indicated by the results of the One Way ANOVA test (p<0.05). The results of the Post Hoc-Tukey test for SGOT levels showed a significant difference between the control group and the 50 mg/kg BW dose group, while the 100, 200 and 400 mg/kg BW doses did not show a significant difference. The results of the Post Hoc-Tukey, s-HSD test for SGPT levels did not show a significant difference between the control group and the 50, 100, 200 and 400 mg/kg BW dose groups. Significant differences were shown by doses of 50 and 400 mg/kg BW. Giving EEKBJB for 28 days did not cause toxic effects on liver function, seen from the absence of an increase in SGOT and SGPT levels.


Keywords


Citrus sinensis L. Osbeck ; SGOT; SGPT

Full Text:

PDF


References

Aditama, T.Y., (2014). Jamu dan Kesehatan. Badan Penelitian dan Pengembangan Kesehatan. Kementerian Kesehatan Republik Indonesia. Bahar, N.W,. (2011). Pengaruh Pemberian Ekstrak dan Fraksi Daun Katuk (Sauropus androgynous (l.) Merr) Terhadap Gambaran Hematologi Pada Tikus Putih Laktasi, Skripsi, Bogor: Fakultas Kedokteran Hewan Institut Pertanian Bogor. Badan POM RI. (2020). Pedoman Uji Toksisitas Pra Klinik Secara In Vivo. Ridwansyah, D.R., (2015). Efek Pemberian Jeruk Manis (Citrus aurantium L.) Sebagai Hepatoprotektor Terhadap Histologis Hepar Tikus Putih Jantan (Rattus novergicus) strain Wistar yang Diinduksi Asetaminofen. Skripsi. Universitas Muhammadyah Malang. Yadav, M., Sehrawat, N., Singh, M., Upadhyay, SK., Aggarwak, D and Sharma, AK., (2020). Cardioprotective and Hepatoprotektif Potential of Citrus Flavonoid Naringin : Current Status and Future Perfectives for Health Benefits, Review article. Asian Journal of Biological and Life Sciences, 9(1) : 1-5. Imantika, C., Amallia, N., Setyawati, Kusmiyati, TDK., (2016). Pengaruh Ekstrak Daun Dewa (Gynura divaricata) Terhadap Kadar SGOT dan SGPT (Studi Eksperimental Pada tikus Sprague dawley Betina Model Kanker Payudara, Jurnal Kedokteran Diponegoro, 5(4). Panjaitan, R., E.Handharyani, Chairul, Masriani, U.Zakiah, Manaliu, (2007). Pengaruh Pemberian Karbon Tetraklorida Terhadap Fungsi Hati dan Ginjal Tikus, Makaira Kesehatan, 11(1): 11-16. Petterino, C, A.A. Storino., (2006). Clinical Chemistry and Haematology Historical Data in Control Sprague-Dawley Rats from Pre-clinical Toxicity Studies, Experimental and Toxicological Pathology, 57: 213-219. Oloche, J., Oluremi, O.I.A. and Paul, J.A., (2015). Performance Response and Blood Profile of West African Dwarf Goats Fed Shea Butter (Vitellaria paradoxa) Leaves Supplemented with Diets Containing Different Levels of Sweet Orange (Citrus sinensis) peels. Journal of Experimental Agriculture International, pp.410-415. Jangid, H., Mukim, M., Ancheria, R. and Sharma, A., (2021). Hepatoprotective Activity of Citrus Limetta on Wistar Albino Rats. Asian Journal of Pharmaceutical Research and Development, 9(1), pp.110-116. Islam, A., Tasnin, M. N., Bari, M. W., Hossain, M. I., & Islam, M. A. (2021). In Vitro Antioxidant and In Vivo Antidiabetic Properties of Citrus Maxima Leaf Extracts in Alloxan-Induced Swiss Albino Diabetic Mice. Asian Food Science Journal, 20(2), 66-79. Mutia, M.S., (2021). Ekstrak Kulit Jeruk Sunkist ; Kajian Antioksidan Bagi Kesehatan Hepar. PUBLISH BUKU UNPRI PRESS ISBN, 1(1). Hernandez, J.M.J., Santiago, O.G., Cabrera, M.A.R., Ferrino, P.C.E and Corona, M.R.C., (2016). Chemistry and Pharmacology of Citrus sinensis : Review. Molecules, 21 (247) 1:24. Guo,C., Shan,Y., Yang, Z., Zhang, L., Ling, W., Liang, Y., et al., (2020). Chemical Composition Anti oxidant, Anti Bacterial, and Thyrosinase Inhibitor Activity of Extracts from Newhall Navel Orange (Citrus sinensis L. Osbeck). Journal of The Science of Food and Agriculture , 100 : 2664-2674.



DOI: https://doi.org/10.22146/jsv.71513

Article Metrics

Abstract views : 320 | views : 150

Refbacks

  • There are currently no refbacks.




Copyright (c) 2024 Jurnal Sain Veteriner

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Sain Veteriner Indexed by

    CrossrefROADCOREProduct DetailsDESKRIPSI GAMBAR


Copyright of JSV (Jurnal Sain Veteriner) ISSN 0126-0421 (print), ISSN 2407-3733 (online).

Fakultas Kedokteran Hewan, Universitas Gadjah Mada

Jl. Fauna No.2, Karangmalang, Yogyakarta

Phone: 0274-560862

Fax: 0274-560861

Email: jsv_fkh@ugm.ac.id

HP. 0895363078367

Jurnal Sain Veteriner is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 

free
web stats View My Stats