The Effect of Turmeric (Curcuma Domestica Val.) Extract on the Histopathological Lesions of Lung Induced by Cigarette Smokes in Wistar Rats
laelatul Rahmad(1*), Nida Ul Milah(2), Agapietta Kusumawardani(3), Novi Herliyani(4), Kurniati Sarwendah(5), Bambang Sutrisno(6), Hastari Wuryastuti(7), R Wasito(8)
(1) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(2) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(3) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(4) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(5) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(6) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(7) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(8) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(*) Corresponding Author
Abstract
This present study is aimed to observe and determine the effects of turmeric (Curcuma domestica Val.) extract administration towards the cytotoxicity effect of cigarette smokes in the lungs of Wistar rats. Twenty Wistar rats, male, 3 months old, were used and divided randomly into four groups, of five each. Group I is as a control (K I), Group II was given 9 cigarettes/day without turmeric extract administration (K II), Group III given
turmeric extract 1 ml 0.25%/day (K III) and Group IV was given 9 cigarettes/day and turmeric extract 0.25%/day (K IV) for 60 days. At the end of the present study, all rats were necropsied and organs, particularly the lungs were collected, processed histopatologically and stained routenely with hematoxilyn eosin. The results indicated that the lungs had macrophages infiltration in the septal alveoli and hyperplasia of bronchial associated lymphoid
tissue (K II). Whereas, the lungs in the rats in Groups K I, K III and K IV were still within the normal limits. It is concluded, that turmeric extract may have a potential anti
pulmonary cytotoxity effect due to cigarette smoke.
Keywords
Full Text:
PDFReferences
Daftar Pustaka
Alwan, A. (2012) WHO Report on the global
tobacco epidemic, 2011: Progress continuesnearly
8 billion people are now covered by an
effective tobacco control measure.WHO Press,
Avenue Appia, 1211 Geneva 27,
Switzerland.
Aoshiba, K. and Nagai, A. (2003) Oxidative stress,
cell death and other damage to alveolar
epithelial cells induced by cigarette smoke. J.
Tobacco Induced Dis. 1: 219-226.
Banks, W.J. (1993) Applied veterinary histology 3rd.
Mosby, Philadelphia, USA. Pp 392-394,397-
Bienenstock, J. and Robert, L.C. (2007) Bronchus
associated lymphoid tissues: Inductive and
Effector Tissues and Cells of the Mucosal
Immune System.University of Alabama,
Birmingham, USA. http//dx.doi.org diakses
pada tanggal 20 Mei, 2013.
Barnes, P.J and Manuel, G.S. (2004). Characteristic
of T lymphocytes in chronic obstructive
pulmonary disease. PloS Med. 1: 25-27.
Cunningham, J.G. (2002) Textbook of veterinary
physiology3rd ed. W.B. Saunders Company,
John Kennedy Boulevard #1800,
Philadelphia, USA.
Geiss, O. and Dimitrios, K. (2007) Tobacco,
cigarettes and cigarette smoke: An
overview.Institute for Health and Consumer
Protection, Italia.
diakses pada
tanggal 15 April, 2012.
Kumar, V., Abul, K.A., and Nelson, F. (2005)
Robbins and cotran pathologic basis of disease
th. Elsevier Saunders, The Curtis Center 170 S
Independence Mall W 300E, Philadelphia,
USA.
Laniado, R.L. (2009) Smoking and chronic
obstructive pulmonary disease (COPD),
parallel epidemics of the 21st century. Int. J.
Environ. Res. Public Health 6: 209-224.
Martey, C A., C. J. Baglole, T. A. Gasiewicz, P. J.
Sime and R. P. Phipps. (2005) The aryl
hydrocarbon receptor is a regulator of cigarette
smoke induction of the cyclooxygenase and
prostaglandin pathways in human lung
fibroblasts. J Phy. Lung Cell Mol. Phy. 289:
L391– L399.
Greaves, P. (2000) histopathology of preclinical
toxicity studies: Respiratory tract. 2nd ed. MRC
Toxicology Unit University of Leicester, UK.
http//dx.doi.org diakses pada tanggal 20 Mei,
H i g d o n , J . ( 2 0 0 5 ) C u r c u m i n ,
Mazumder, R., Bhattaraya, S., Jha, S., Mazumder,
A., Kumari, J., and Jha, S. (2007) Studies on
pharmacognostical features of Curcuma
domestica Val. J. Ancient Scie. Life 26.4: 37-41.
http://lpi,oragonstate.edu/intocenter/
phytochemical/ curcumin
Petrescu, F., V. Biciusca, Octavia, I.P., and C.M.,
Fortofoiu (2013) Cellular basis of bronchial
inflammation in chronic obstructive pulmonary
disease(COPD). J. Cur. Health Scie. 39: 61-67.
Rahman, I. (2002) Oxidative stress, chromatin
remodeling and gene transcription in
inflammation and chronic lung diseases. J.
Bioch.Mol. Biol. 36: 95-109.
Renne, R.A., D.L., Dungworth, C.M., Keenan, K.T.,
Morgan, F.F., Hahn, and L.W., Schwartz(2003)
Non-proliverative lesions of the respiraory
tract in rats. Guides Tox. Path.: 1-26.
Rahman, I. (2003) Oxidative stress, chromatin
remodeling and gene transcription in
inflammation and chronic lung diseases. Rev. J.
Bioch. Mol. Biol. 1: 95-109.
Reimondos, A., Utomo, I.D., McDonald, P., Hull, P.,
Suparno, H.and Utomo, A. (2012) The 2010
greater Jakarta transition to adulthood survey
policy background No. 2 smoking and young
adults in Indonesia diakses pada tanggal 18
November, 2012.
Samuelson, D.A. (2007) Textbook of veterinary
histology 2nd edition. Saunders Elsevier Inc.,
Westline Industrial Drive St. Louis,
Missouri, USA.
Shishodia, S., Tulika, S. and Madan, M.C. (2007)
Modulation of transcription factor by
curcumin. Adv. Exp. Med. Bio. 595: 127-148.
Tsai, S., Huang, S., Chyau, C., Tsai, C., Weng, C.,
and Mau, J. (2011) Composition and
antioxidant properties of essential oils from
Curcuma rhizome. Asian J. Arts Scie. 2: 57-66.
Thorley, A.J. and Teresa, D.T. (2007) Pulmonary
epithelium, cigarette smoke,and chronic
obstructive pulmonary disease. Int. J. COPD 2:
–428.
Tucker, M.J. (2003) Disease of Wistar. Taylor and
Francis Inc. 1900 Frost Road, Suite 101,
Bristol, Philadelphia, USA.
Venkatesan, N., Durairaj, P. and Mary, B. (2007)
Protection from acute and chronic lung disease
by curcumin in: the molecular targets and
therapeutic uses of curcumin in health and
disease. Adv. Exp. Med. Biol. 595:379-405.
Yoshida, T. and Rubin, M.T. (2007) Pathobiology of
cigarette smoke-induced chronic obstructive
pulmonary disease. Physiol. Rev.87:
–1082.
DOI: https://doi.org/10.22146/jsv.8109
Article Metrics
Abstract views : 2208 | views : 3607Refbacks
- There are currently no refbacks.
Copyright (c) 2015 Jurnal Sain Veteriner
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Jurnal Sain Veteriner Indexed by
Copyright of JSV (Jurnal Sain Veteriner) ISSN 0126-0421 (print), ISSN 2407-3733 (online).
Fakultas Kedokteran Hewan, Universitas Gadjah Mada
Jl. Fauna No.2, Karangmalang, Yogyakarta
Phone: 0274-560862
Fax: 0274-560861
Email: jsv_fkh@ugm.ac.id
HP. 0895363078367
Jurnal Sain Veteriner is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
View My Stats