Histological Analysis of Intestinum Tenue Rabbit Atherosclerosis Model

https://doi.org/10.22146/jsv.81748

Vista Budiariati(1*), Ariana .(2), Teguh Budipitojo(3)

(1) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(2) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(3) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Atherosclerosis is a vascular disease that occurs as a result of a progressive inflammatory response in blood vessels. The method of inducing atherosclerosis with the rabbit animal model can be done by modifying the high-fat diet which can lead to hypercholesterolemia within a few days to the inducement of atheromatic lesions. This study was conducted to analyze the histology of the small intestine in a group of rabbits fed with standard diet and atherosclerosis model of rabbits fed with atherogenic diet. The results of morphometry analysis in the small intestine showed that the duodenal submucosa in group B was wider than group A, while the length of jejunal villi in group B was shorter than group A. Changes in the intestine were also followed by changes in the cell population. The number of goblet cells in the duodenum was less in group B compared to group A, but the number of goblet cells in the jejunum was actually more in group B than in group A. Further research is needed to determine the mechanism that causes this change so that it can support modeling of atherosclerosis in rabbits according to the pathophysiology and pathogenesis of diseases that occur in humans.


Keywords


atherosclerosis; histology; rabbit; high-fat diet; small intestine

Full Text:

PDF


References

Baumgartner, C., Brandl, J., Münch, G., Ungerer, M. (2016). Rabbit models to study atherosclerosis and its complications – Transgenic vascular protein expression in vivo. Progress in Biophysics and Molecular Biology. Jul;121(2): 131-141. Celia, P., Cowiesonb, F., Fru-Njib, R.E., Steinertc, A.M., Kluenterb, V., Verlhacd. (2017). Gastrointestinal functionality in animal nutrition and health: New opportunities for sustainable animal production. Animal Feed Science and Technology. 234: 88–100. Elnasharty, M.A., Abou-Ghanema, I.I., Sayed-Ahmed, A., Abo Elnour. (2013). Mucosal- Submucosal Changes in Rabbit Duodenum during Development. World Academy of Science, Engineering and Technology. 76: 500-508. Ermayanti, N.G.A.M., 1, Suarni, N.M.R., Widhyastini, I.G.A.M. (2019). Effect of Cod Liver Oil Supplementation in Feed on the Haematological Values and Concentration of Epididymis Spermatozoa of Local Rabbits. IOP Conf. Ser.: Earth Environ. Sci. 709 012057. Fan, J., Kitajima, S., Watanabe, T., Xu, J., Zhang, J., Liu, E., Chen, YE. (2015). Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine. Pharmacol Ther. Feb;146: 104-119. Hrapkiewicz, K., Colby, L., dan Denison, P. (2013). Clinical Laboratory Animal Medicine: An introduction 6th. Hoboken: Willey-Blackwell. Lee, Y.T., Laxton, V., Lin, H.Y., Chan, Y.W., Fitzgerald Smith, S., To, T., Tse, G. (2017). Animal models of atherosclerosis (Review). Biomedical Reports. 6: 259-266. Meidayanti, D. (2021). Manfaat Likopen dalam Tomat sebagai Pencegahan Terhadap Timbulnya Aterosklerosis. Jurnal Medika Hutama. 2(3): 906-910. Nordestgaard, B.G., Chapman, M.J., Humphries, S.E., Ginsberg, H.N., Masana, L., Descamps, O.S., Wiklund, O., Hegele, R.A., Raal, F.J., Defesche, J.C. (2013). European Atherosclerosis Society Consensus Panel: Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J. 34:3478–3490a. Ramalho, J., Antunes., Hidalgo. (2017). Metabolic disturbances due to a high-fat diet in a non-insulinresistant animal model. Nutrition & Diabetes. 7: e245. Ranjan, R. and Das P. (2020). Gross, Histological, dan Morphometrical Studies on The Small Intestine. Haryana Vet. 59(1): 75-79. Shiomi, M., and Ito, T. (2009). The Watanabe heritable hyperlipidemic (WHHL) rabbit, its characteristics and history of development: a tribute to the late Dr. Yoshio Watanabe. Atheroscler. 207: 1–7. Soares, A., Beraldi, E.J., Ferreira, P.E.B., Bazotte, R.B., Buttow, NC. (2015). Intestinal and neuronal myenteric adaptations in the small intestine induced by a high-fat diet in mice. BMC Gastroenterol. 15(3): 1-9. Yanni, A.E. (2004). The laboratory rabbit: an animal model of atherosclerosis research Laboratory Animals Ltd. Laboratory Animals. 38: 246–256.



DOI: https://doi.org/10.22146/jsv.81748

Article Metrics

Abstract views : 1231 | views : 1443

Refbacks

  • There are currently no refbacks.




Copyright (c) 2023 Jurnal Sain Veteriner

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Sain Veteriner Indexed by

    CrossrefROADCOREProduct DetailsDESKRIPSI GAMBAR


Copyright of JSV (Jurnal Sain Veteriner) ISSN 0126-0421 (print), ISSN 2407-3733 (online).

Fakultas Kedokteran Hewan, Universitas Gadjah Mada

Jl. Fauna No.2, Karangmalang, Yogyakarta

Phone: 0274-560862

Fax: 0274-560861

Email: jsv_fkh@ugm.ac.id

HP. 0895363078367

Jurnal Sain Veteriner is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 

free
web stats View My Stats