Optimasi Formula Sediaan Krim o/w Kombinasi Oksibenzon dan Titanium Dioksida Serta Uji Aktivitas Tabir Suryanya Secara In Vivo



Ribka Elcistia(1), Abdul Karim Zulkarnain(2*)

(1) Fakultas Farmasi, Universitas Gadjah Mada Yogyakarta
(2) Fakultas Farmasi, Universitas Gadjah Mada Yogyakarta
(*) Corresponding Author

Abstract


Efek buruk dari sinar matahari dapat dikurangi dengan penggunaan tabir surya. Optimasi emulgator trietanolamin (TEA) stearat dan setil alkohol pada krim tabir surya kombinasi oksibenzon dan titanium dioksida diharapkan menghasilkan formula optimum krim dengan stabilitas fisik yang baik. Tujuan penelitian ini yaitu mengetahui proporsi TEA stearat dan setil alkohol formula optimum dan nilai SPF krim o/w kombinasi oksibenzon dan titanium dioksida. Penetapan formula optimum dilakukan pada data uji sifat fisik krim menggunakan metode Simplex Lattice Design design software Design Expert version 9.0.4. Uji one sample t-test dilakukan untuk mengetahui perbedaan nilai antara formula optimum yang dihasilkan software Design Expert version 9.0.4 dengan hasil percobaan. Perbandingan sifat fisik formula optimum krim o/w kombinasi oksibenzon dan titanium oksida selama penyimpanan 4 minggu dianalisis menggunakan uji ANOVA. Pengujian nilai SPF secara in vivo dilakukan pada kelinci betina galur New Zealand White terinduksi senyawa 8-metoksiprosalen. Hasil penelitian menunjukkan proporsi TEA stearat dan setil alkohol yang menghasilkan formula optimum krim o/w kombinasi oksibenzon dan titanium dioksida adalah 8.93% dan 2.07%. Sifat fisik viskositas dan daya lekat tidak berbeda signifikan, sedangkan daya sebar berbeda signifikan selama penyimpanan 4 minggu. Pengujian aktivitas tabir surya secara in vivo krim o/w kombinasi oksibenzon dan titanium dioksida menghasilkan nilai SPF 12.

Keywords


oksibenzon, titanium dioksida, tabir surya, in vivo

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