Narrative Review : Probiotik Sebagai Antijerawat Dalam Sediaan Topikal

https://doi.org/10.22146/farmaseutik.v18i3.72962

Gigih Mukti Leksono(1), Angi Nadya Bestari(2), Purwanto Purwanto(3*)

(1) Mahasiswa Sarjana Fakultas Farmasi UGM
(2) Departemen Farmasetika, Fakultas Farmasi UGM
(3) Departemen Biologi Farmasi, Fakultas Farmasi UGM
(*) Corresponding Author

Abstract


Jerawat adalah inflamasi kulit kronis yang terjadi pada banyak orang yang disebabkan salah satunya oleh ketidakseimbangan mikrobioma (disbiosis) kulit berupa hiperkolonisasi Cutibacterium acnes. Probiotik mampu menekan patogen dalam saluran pencernaan dan beberapa tahun terakhir telah dimanfaatkan sebagai bahan aktif dalam kosmetik. Tujuan dari penelitian ini adalah untuk menilai potensi produk topikal mengandung probiotik dalam aktivitas sebagai antijerawat. Penelitian ini dilakukan dengan cara narrative review dan dilakukan dalam empat tahap yaitu penentuan kata kunci, kriteria inklusi dan eksklusi, seleksi literatur, dan analisis hasil. Pencarian literatur dilakukan melalui database elektronik daring seperti Scopus, PubMed, Science Direct, dan Wiley Online Library. Dari review yang dilakukan diperoleh data bahwa berbagai jenis probiotik memiliki aktivitas antimikroba, khususnya antijerawat melalui ekskresi hidrogen peroksida, senyawa asam, bakteriosin, dan bacteriocin-like inhibitory substances (BLIS). Probiotik dapat dimanfaatkan dalam kondisi hidup maupun tak hidup, diformulasikan menjadi berbagai jenis sediaan topikal, dan terbukti bermanfaat sebagai antijerawat dengan penggunaan yang sesuai.


Keywords


probiotik; jerawat; sediaan topikal; antibakteri

Full Text:

PDF


References

Bielecka, M. (2006). Probiotics in food. Chemical and Functional Properties of Food Components, Third Edition, 413–426. https://doi.org/10.1201/9781420009613.ch16

BioFense – ProTec Ingredia. (n.d.). Retrieved February 9, 2022, from https://protecingredia.com/products/barnet/biofense.html

Christensen, G. J. M., Scholz, C. F. P., Enghild, J., Rohde, H., Kilian, M., Thürmer, A., Brzuszkiewicz, E., Lomholt, H. B., & Brüggemann, H. (2016). Antagonism between Staphylococcus epidermidis and Propionibacterium acnes and its genomic basis. BMC Genomics, 17(1), 1–14. https://doi.org/10.1186/s12864-016-2489-5

Fitz-Gibbon, S., Tomida, S., Chiu, B. H., Nguyen, L., Du, C., Liu, M., Elashoff, D., Erfe, M. C., Loncaric, A., Kim, J., Modlin, R. L., Miller, J. F., Sodergren, E., Craft, N., Weinstock, G. M., & Li, H. (2013). Propionibacterium acnes strain populations in the human skin microbiome associated with acne. Journal of Investigative Dermatology, 133(9), 2152–2160. https://doi.org/10.1038/jid.2013.21

Goodarzi, A., Mozafarpoor, S., Bodaghabadi, M., & Mohamadi, M. (2020). The potential of probiotics for treating acne vulgaris: A review of literature on acne and microbiota. Dermatologic Therapy, 33(3). https://doi.org/10.1111/DTH.13279

Hsiao, K. H., Huang, C. M., & Lee, Y. H. (2018). Development of Rifampicin-Indocyanine green-loaded perfluorocarbon nanodroplets for photo-chemo-probiotic antimicrobial therapy. Frontiers in Pharmacology, 9(NOV), 1–12. https://doi.org/10.3389/fphar.2018.01254

Hsiao, K. H., Huang, C. M., & Lee, Y. H. (2020). Novel rifampicin and indocyanine green co-loaded perfluorocarbon nanodroplets provide effective in vivo photo–chemo–probiotic antimicrobility against pathogen of acne vulgaris Cutibacterium acnes. Nanomaterials, 10(6). https://doi.org/10.3390/nano10061095

Htwe, M. M., Teanpaisan, R., Khongkow, P., & Amnuaikit, T. (2019). Liposomes of probiotic’s lyophilized cell free supernatant; A potential cosmeceutical product. Pharmazie, 74(8), 462–466. https://doi.org/10.1691/ph.2019.9030

Kober, M. M., & Bowe, W. P. (2015). The effect of probiotics on immune regulation, acne, and photoaging. International Journal of Women’s Dermatology, 1(2), 85–89. https://doi.org/10.1016/j.ijwd.2015.02.001

Marson, J. W., & Baldwin, H. E. (2019). New Concepts, Concerns, and Creations in Acne. Dermatologic Clinics, 37(1), 1–9. https://doi.org/10.1016/j.det.2018.07.002

Mottin, V. H. M., & Suyenaga, E. S. (2018). An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis. International Journal of Dermatology, 57(12), 1425–1432. https://doi.org/10.1111/IJD.13972

Muizzuddin, N., Maher, W., Sullivan, M., Schnittger, S., & Mammone, T. (2012). Physiological effect of a probiotic on skin. Journal of Cosmetic Science, 63(6), 385–395. https://europepmc.org/article/med/23286870

Nole, K. L. B., Yim, E., & Keri, J. E. (2014). Probiotics and prebiotics in dermatology. Journal of the American Academy of Dermatology, 71(4), 814–821. https://doi.org/10.1016/j.jaad.2014.04.050

Paetzold, B., Willis, J. R., Lima, J., Knodlseder, N., Quist, S. R., Gabaldón, T., & Güell, M. (2018). Skin microbiome modulation induced by probiotic solutions. BioRxiv, 1–9. https://doi.org/10.1101/423285

Probiotic health food for the skin - CLR Berlin. (n.d.). Retrieved February 9, 2022, from https://www.clr-berlin.com/de/probiotic-health-food-for-the-skin/

Rathi, S. K. (2011). ACNE VULGARIS TREATMENT : THE CURRENT SCENARIO. Indian Journal of Dermatology, 56(1), 7. https://doi.org/10.4103/0019-5154.77543

Tagliolatto, S., França, P. F., & dos Santos, K. M. P. (2020). Use of topical tyndallized probiotic bacteria in the treatment of acne vulgaris. Surgical and Cosmetic Dermatology, 12(2), 148–155. https://doi.org/10.5935/scd1984-8773.202012207

Tan, J. K. L., & Bhate, K. (2015). A global perspective on the epidemiology of acne. The British Journal of Dermatology, 172 Suppl(S1), 3–12. https://doi.org/10.1111/BJD.13462

Tayupanta, D. L. A. M. T., & Ocana, V. S. P. (2019). In vivo Evaluation of the Antagonistic Effect of Lactobacillus acidophilus against Propionobacterium acnes in the Treatment of Acne. Journal of Pure and Applied Microbiology, 13(3), 1317–1324. https://doi.org/10.22207/JPAM.13.3.03

Wang, Y., Kuo, S., Shu, M., Yu, J., Huang, S., Dai, A., Two, A., Gallo, R. L., & Huang, C. M. (2015). Implications of probiotics in acne vulgaris. NIH Public Access, 25(8), 411–424. https://doi.org/10.1007/s00253-013-5394-8.Staphylococcus

Yang, A. J., Marito, S., Yang, J. J., Keshari, S., Chew, C. H., Chen, C. C., & Huang, C. M. (2019). A microtube array membrane (MTAM) encapsulated live fermenting staphylococcus epidermidis as a skin probiotic patch against cutibacterium acnes. International Journal of Molecular Sciences, 20(1). https://doi.org/10.3390/ijms20010014



DOI: https://doi.org/10.22146/farmaseutik.v18i3.72962

Article Metrics

Abstract views : 1402 | views : 2292

Refbacks

  • There are currently no refbacks.


Majalah Farmaseutik Indexed by:

   
 
Creative Commons Licence
 
 
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.