Efektivitas Pemberian Penyekat Pompa Proton Rute Intravena Drip dan Intermiten Pada Perdarahan Saluran Cerna Atas Nonvariseal

Berliana Luthfiananda; Ika Puspita Sari; Catharina Triwikatmani

doi:10.22146/farmaseutik.v20i2.84723

Efektivitas Pemberian Penyekat Pompa Proton Rute Intravena Drip dan Intermiten Pada Perdarahan Saluran Cerna Atas Nonvariseal

https://doi.org/10.22146/farmaseutik.v20i2.84723

Berliana Luthfiananda^(1*), Ika Puspita Sari⁽²⁾, Catharina Triwikatmani⁽³⁾

(1) Gadjah Mada University
(2) Gadjah Mada University
(3) Dr. Sardjito Hospital
(*) Corresponding Author

Abstract

Perdarahan saluran cerna bagian atas (PSCBA) nonvariseal merupakan perdarahan yang memiliki insidensi yang tinggi dan tingkat hospitalisasi yang terus meningkat. Salah satu terapi yang dapat membantu mengurangi risiko perdarahan adalah Penyekat Pompa Proton (Proton Pump Inhibitor/PPI) yang sampai saat ini masih mengalami perdebatan terkait rute pemberian intravena drip dan intermiten. Pembahasan ini bertujuan untuk menganalisis rute pemberian yang tepat pada PSCBA nonvariseal untuk meningkatkan efektivitas terapi. Literatur yang digunakan dicari dengan pustaka elektronik melalui database Google Scholar, Pubmed, dan Science direct dari tahun 2013 – 2023. Luaran klinik yang diamati ialah adanya perdarahan ulang atau lama rawat inap dirumah sakit. Pemberian dengan rute intravena drip dan intermiten tidak berbeda signifikan berdasarkan luaran klinik tingkat perdarahan dan perdarahan ulang. Pemberian dengan rute intravena intermiten masih dapat digunakan untuk mengurangi peningkatan biaya perawatan.

Keywords

Intravenous Infusion; Length of Stay: Gastrointestinal Haemorrhage; Proton Pump Inhibitors

Full Text:

PDF

References

Alzubaidi, A. S., & Basilim, A. F. (2022). Comparison of intermittent and continuous proton pump inhibitor infusions in patients with non-variceal upper gastrointestinal bleeding at King Abdulaziz University Hospital, Jeddah, Saudi Arabia: A retrospective study. Saudi Medical Journal, 43(8), 941–945. https://doi.org/10.15537/smj.2022.43.8.20220128 Chambers, D. J. (2019). Principles of intravenous drug infusion. Anaesthesia & Intensive Care Medicine, 20(1), 61–64. https://doi.org/10.1016/j.mpaic.2018.11.005 Gralnek, I. M., Stanley, A. J., Morris, A. J., Camus, M., Lau, J., Lanas, A., Laursen, S. B., Radaelli, F., Papanikolaou, I. S., Cúrdia Gonçalves, T., Dinis-Ribeiro, M., Awadie, H., Braun, G., De Groot, N., Udd, M., Sanchez-Yague, A., Neeman, Z., & Van Hooft, J. E. (2021). Endoscopic diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH): European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2021. Endoscopy, 53(03), 300–332. https://doi.org/10.1055/a-1369-5274 Hreinsson, J. P., Kalaitzakis, E., Gudmundsson, S., & Björnsson, E. S. (2013). Upper gastrointestinal bleeding: Incidence, etiology and outcomes in a population-based setting. Scandinavian Journal of Gastroenterology, 48(4), 439–447. https://doi.org/10.3109/00365521.2012.763174 Kearns, G. L., Blumer, J., Schexnayder, S., James, L. P., Adcock, K. G., Reed, M. D., Daniel, J. F., Gaedigk, A., & Paul, J. (2008). Single-Dose Pharmacokinetics of Oral and Intravenous Pantoprazole in Children and Adolescents. The Journal of Clinical Pharmacology, 48(11), 1356–1365. https://doi.org/10.1177/0091270008321811 Leung, T., Kedzior, S., Moore, K., Bierman, J., & Coralic, Z. (2022). Intermittent Versus Continuous Infusion Dosing of Intravenous Proton Pump Inhibitors for Upper Gastrointestinal Bleeding. Annals of Pharmacotherapy, 56(10), 1127–1132. https://doi.org/10.1177/10600280211073936 Lim, H. (2015). Effect of low‐dose proton pump inhibitor on preventing upper gastrointestinal bleeding in chronic kidney disease patients receiving aspirin—Lim—2015—Journal of Gastroenterology and Hepatology—Wiley Online Library. https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.12780 Mahajan, U., Rana, B.S., Kapoor, D., & Kumar, P. (2018, September). (PDF) A study to compare the efficacy of intermittent versus continuous regimen of pantaprazole in the management of upper gastrointestinal bleed (non variceal). https://www.researchgate.net/publication/328524643_A_study_to_compare_the_efficacy_of_intermittent_versus_continuous_regimen_of_pantaprazole_in_the_management_of_upper_gastrointestinal_bleed_non_variceal Pisegna, J. R., Sostek, M. B., Monyak, J. T., & Miner Jr, P. B. (2008). Intravenous esomeprazole 40 mg vs. Intravenous lansoprazole 30 mg for controlling intragastric acidity in healthy adults. Alimentary Pharmacology & Therapeutics, 27(6), 483–490. https://doi.org/10.1111/j.1365-2036.2007.03592.x Rattanasupar, A., & Sengmanee, S. (2016). Comparison of High Dose and Standard Dose Proton Pump Inhibitor before Endoscopy in Patients with Non-Portal Hypertension Bleeding. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 99(9), 988–995. Rodríguez, L. A. G., Martín-Pérez, M., Hennekens, C. H., Rothwell, P. M., & Lanas, A. (2016). Bleeding Risk with Long-Term Low-Dose Aspirin: A Systematic Review of Observational Studies. PLOS ONE, 11(8), e0160046. https://doi.org/10.1371/journal.pone.0160046 Sung, J. J., Chiu, P. W., Chan, F. K. L., Lau, J. Y., Goh, K., Ho, L. H., Jung, H., Sollano, J. D., Gotoda, T., Reddy, N., Singh, R., Sugano, K., Wu, K., Wu, C.-Y., Bjorkman, D. J., Jensen, D. M., Kuipers, E. J., & Lanas, A. (2018). Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: An update 2018. Gut, 67(10), 1757–1768. https://doi.org/10.1136/gutjnl-2018-316276 van Eck van der Sluijs, A., Abrahams, A. C., Rookmaaker, M. B., Verhaar, M. C., Bos, W. J. W., Blankestijn, P. J., Dekker, F. W., van Diepen, M., & Ocak, G. (2021). Bleeding risk of haemodialysis and peritoneal dialysis patients. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association, 36(1), 170–175. https://doi.org/10.1093/ndt/gfaa216 Worden, J. C., & Hanna, K. S. (2017). Optimizing proton pump inhibitor therapy for treatment of nonvariceal upper gastrointestinal bleeding. American Journal of Health-System Pharmacy, 74(3), 109–116. Yao, D.-K., Chen, H., Wang, L., Li, H.-W., & Wang, L.-X. (2015). Comparison of Intravenous plus Oral Pantoprazole Therapy and Oral Pantoprazole Alone for Preventing Gastrointestinal Bleeding in Acute Coronary Syndrome Patients with High Bleeding Risk. Heart, Lung and Circulation, 24(9), 885–890. https://doi.org/10.1016/j.hlc.2015.02.020

DOI: https://doi.org/10.22146/farmaseutik.v20i2.84723