Discordance between Activated Partial Thromboplastin Time and Anti-factor Xa in Unfractionated Heparin Monitoring: Literature Review

Debora Purwasista Ciptasari; Rizaldy Taslim Pinzon; Agung Endro Nugroho

doi:10.22146/farmaseutik.v20i4.98746

Discordance between Activated Partial Thromboplastin Time and Anti-factor Xa in Unfractionated Heparin Monitoring: Literature Review

https://doi.org/10.22146/farmaseutik.v20i4.98746

Debora Purwasista Ciptasari⁽¹⁾, Rizaldy Taslim Pinzon⁽²⁾, Agung Endro Nugroho^(3*)

(1) Master Program in Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada
(2) Bethesda Hospital, Yogyakarta
(3) Fakultas Farmasi, Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Anticoagulants are prescribed very frequently, but their use is often associated with adverse drug reactions. The optimal monitoring of heparin is unknown, either by aPTT or anti-Xa levels. This paper compares which anti-Xa or aPTT most closely correlates with patients on intravenous heparin. This review also compares the achievement of target goals of unfractionated heparin (UFH) using aPTT and anti-Xa tests. Literature searching was started in June 2024 and ended in July 2024 through some online scientific databases: Scopus, PubMed, Google Scholar, Science Direct, and Willey Online Library. This review includes fifteen studies, at least involving 2,938 patients or 94,038 sets of measurements. The review demonstrates that anti-Xa outperforms aPTT in achieving the therapeutic range of unfractionated heparin, time to therapeutic goal, and dose modification.

Keywords

anti-xa; apt; UFH; monitoring; discordance

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DOI: https://doi.org/10.22146/farmaseutik.v20i4.98746