* Corresponding Author
Efek antikaries ekstrak gambir pada tikus jantan galur wistar
https://doi.org/10.22146/majkedgiind.17407 Siti Rusdiana Puspa Dewi(1*), Dina Oktaviani Marlamsya(2), Rini Bikarindrasari(3)
(1) University of Sriwijaya
(2) Program Studi Kedokteran Gigi, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Sumatera Selatan
(3) Bagian Konservasi Gigi, Program Studi Kedokteran Gigi, Fakultas Kedokteran, Universitas Sriwijaya, Palembang, Sumatera Selatan
(*) Corresponding Author
Abstract
Anti-caries effect of gambier extract on male wistar rats. Several previous studies have mentioned that gambir extract can inhibit the growth of Streptococcus mutans (S. mutans) because it contains active substances of catechins and tannins. The objective of this study was to explore the anti-caries effect of gambir extract on male Wistar rats. Thirty-six Wistar rats were inoculated with S. mutans, given cariogenic foods and divided into 4 groups according to the doses of gambir extract, namely 6 mg, 12 mg, 24 mg and placebo. After 60 days, the rats were euthanized, then the number of caries on the mesial or distal and occlusal surfaces was counted by using the Keyes’ method. The data were analyzed using Kruskal Wallis test. The results revealed that caries was found only in occlusal surfaces with an enamel depth. There is no significant difference among all the groups, so it can be concluded that gambir extract at 6 mg, 12 mg and 24 mg doses do not have anti-caries effect on the teeth of male Wistar rats.
ABSTRAK
Beberapa penelitian terdahulu mengatakan bahwa ekstrak gambir dapat menghambat pertumbuhan Steptococcus mutans (S. mutans) karena mengandung zat aktif katekin dan tanin. Tujuan dari penelitian ini adalah untuk melihat efek antikaries ekstrak gambir pada tikus jantan galur Wistar. Tiga puluh enam ekor tikus galur Wistar diinokulasi dengan S. mutans, diberikan makanan kariogenik dan dibagi menjadi 4 kelompok, yakni, kelompok yang diberi dosis ekstrak gambir 6 mg, 12 mg, 24 mg dan plasebo. Setelah 60 hari, tikus di eutanasia, kemudian dihitung jumlah karies pada permukaan halus dan oklusal dengan menggunakan metode Keyes. Data dianalisa dengan menggunakan tes Kruskal Wallis. Hasil penelitian diketahui bahwa karies ditemukan hanya pada pemukaan oklusal dengan kedalaman email. Tidak ada perbedaan signifikan antar semua kelompok, sehingga dapat disimpulkan bahwa ekstrak gambir dengan dosis 6 mg, 12 mg dan 24 mg tidak memiliki efek antikaries pada gigi tikus jantan galur Wistar.
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DOI: https://doi.org/10.22146/majkedgiind.17407
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