* Corresponding Author
Radiographic analysis of teeth calcification of breastfed rat cubs of mothers consuming excessive Arabica coffee
https://doi.org/10.22146/majkedgiind.80243 Dwi Kartika Apriyono(1), Amandia Dewi Permana Shita(2*), Nadie Fatimatuzzahro(3), Rendra Chriestedy Prasetya(4), Ulfa Umaimah(5)
(1) Department of Dentistry-Forensic Odontology, Faculty of Dentistry, University of Jember, East Java
(2) Department of Dentistry-Biomedical Sciences, Oral Pathology and Maxillofacial, Faculty of Dentistry, University of Jember, East Java
(3) Department of Dentistry-Biomedical Sciences, Oral Pathology and Maxillofacial, Faculty of Dentistry, University of Jember, East Java
(4) Department of Dentistry-Biomedical Sciences, Oral Pathology and Maxillofacial, Faculty of Dentistry, University of Jember, East Java
(5) Bachelor of Dentistry, Faculty of Dentistry, University of Jember, East Java
(*) Corresponding Author
Abstract
Lack of nutrient intake, especially calcium, can inhibit tooth development because calcium is the major component of the inorganic material that forms enamel and dentin. Caffeine in coffee can decrease calcium levels in the body. Arabica coffee has a very high caffeine content compared to other types of coffee. Excessive caffeine consumption can cause the inhibition of PTH secretion. As a result, the nursing mother's body cannot absorb calcium optimally. This makes the baby lack calcium intake which is used for the dental calcification process. This study analyzes radiographic images of tooth calcification of rat cubs during lactation period from rat mothers which consumed excess doses of Arabica coffee. Forty-eight breastfeeding rat mothers (n = 48) were divided into a control group and a treatment group. The control group consisted of 24 rat mothers that were given aquadest. The treatment group consisted of 24 nursing rat mothers, which were given coffee orally at a dose of 2.7 grams/200 grams/day. After the rat mothers gave birth (H + 1 to H + 18), every 4 rat cubs were euthanized, then the mandibular bones were X-rayed. Dental calcification was viewed and analyzed based on radiographic images. The teeth of rat cubs whose mothers consumed excess doses of Arabica coffee experienced a delay in the calcification stage compared to the teeth of normal rat cubs. Consumption of Arabica coffee by nursing mothers can cause a delay in the stage of dental calcification in rat cubs.
Keywords
Full Text:
PDFReferences
1. Primasari A. Embriologi dan tumbuh kembang rongga mulut. Embriologi dan Tumbuh
Kembang Rongga Mulut. 2018. 97–105.
2. Lailasari D, Zenab Y, Herawati E, Wahyuni IS. Correlation between permanent teeth
eruption and nutrition status of 6-7-years-old children. Padjadjaran Journal of Dentistry.
2018; 30(2): 116-123. doi: 10.24198/pjd.vol30no2.18327
3. Kementrian Kesehatan Republik Indonesia. Laporan Riskesdas 2018 Nasional.pdf. 2019. 674.
4. Stefanello N, Spanevello RM, Passamonti S, Porciúncula L, Bonan CD, Olabiyi AA, da Rocha JBT, Assmann CE, Morsch VM, Schetinger MRC. Coffee, caffeine, chlorogenic acid, and the purinergic system. Food Chem Toxicol. 2019; 123: 298–313. doi: 10.1016/j.fct.2018.10.005
5. Mustafa OE, Khalifa EAEL, Abdoon GTE. The effect of caffeinated beverages on urinary
excretion of minerals in females students. Academic Research Publishing Group. 2018;
4(6): 35–42.
6. Richards G, Smith AP. Caffeine consumption and general health in secondary school
children: a cross-sectional and longitudinal analysis. Front Nutr. 2016; 3: 52.
doi: 10.3389/fnut.2016.00052
7. Aryadi MI, Arfi F, Harahap MR. Perbandingan kadar kafein dalam kopi robusta (coffea
canephora), kopi arabika (coffes arabica) dan kopi liberika (coffea liberica) dengan metode
spektrofotometri UV-Vis. Amina. 2021; 2(2): 64–70.
8. Farida A, Ristanti E, Kumoro AC. Penurunan kadar kafein dan asam total pada biji kopi
robusta menggunakan teknologi fermentasi anaerob fakultatif dengan mikroba nopkor MZ-
15. J Teknol Kim dan Ind. 2013; 2(3) :70–75.
9. Lu M, Farnebo LO, Bränström R, Larsson C. Inhibition of parathyroid hormone secretion
by caffeine in human parathyroid cells. J Clin Endocrinol Metab. 2013; 98(8): E1345–1351.
doi: 10.1210/jc.2013-1466
10. Choirunnisa L, Apriyono DK, Shita ADP. The effect of Arabica coffee consumption during
lactation of breastfeeding Wistar rats on the tooth eruption of the offsprings. Padjadjaran
Journal of Dental Researchers and Students. 2020; 4(2): 90-97.
doi: 10.24198/pjdrs.v4i2.27506
11. Ardiningrum SW, Shita ADP, Apriyono DK. Efek konsumsi kopi arabika berlebih selama
masa laktasi terhadap densitas tulang mandibula anak tikus Wistar The effect of excessive Arabica coffee consumption during lactation on the mandibular bone density of
Wistar rats Infant. Jurnal Kedokteran Gigi Universitas Padjadjaran. 2020; 32(3): 170-177.
doi: 10.24198/jkg.v32i3.27480
12. Allgulander C. Anxiety as a risk factor in cardiovascular disease. Curr Opin Psychiatry. 2016; 29(1): 13-17. doi: 10.1097/YCO.0000000000000217
13. Chau YP, Au PCM, Li GHY, Sing CW, Cheng VKF, Tan KCB, Kung AWC, Cheung CL. Serum metabolome of coffee consumption and its association with bone mineral density:
The Hongkong Osteoporosis Study. J Clin Endocrinol Metab. 2020; 105(3): e619-e627.
doi: 10.1210/clinem/dgz210
14. Silva ST da, Costa NMB, Franco FSC, Natali AJ. Calcium and caffeine interaction in
increased calcium balance in ovariectomized rats. Rev Nutr. 2013; 26(3): 313–22.
doi: 10.1590/S1415-52732013000300006
15. Lehtonen A, Uusitalo L, Auriola S, Backman K, Heinonen S, Keski-Nisula L, Pasanen M,
Pekkanen J, Tuomainen TP, Voutilainen R, Hantunen S, Lehtonen M. Caffeine content in
newborn hair correlates with maternal dietary intake. Eur J Nutr. 2021; 60(1): 193–201.
doi: 10.1007/s00394-020-02231-2
16. Doepker C, Lieberman HR, Smith AP, Peck JD, El-Sohemy A, Welsh BT. Caffeine: Friend
or Foe? Annu Rev Food Sci Technol. 2016; 7(1): 117–137. doi: 10.1146/annurev-food-041715-033243
17. Wikoff D, Welsh BT, Henderson R, Brorby GP, Britt J, Myers E, Goldberger J, Lieberman
HR, O'Brien C, Peck J, Tenenbein M, Weaver C, Harvey S, Urban J, Doepker C. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol. 2017; 109(1): 585–648. doi: 10.1016/j.fct.2017.04.002
18. Silva CG, Métin C, Fazeli W, Machado NJ, Darmopil S, Launay PS, Ghestem A, Nesa MP, Bassot E, Szabó E, Baqi Y, Müller CE, Tomé AR, Ivanov A, Isbrandt D, Zilberter Y, Cunha RA, Esclapez M, Bernard C. Adenosine receptor antagonists including caffeine alter fetal brain development in mice. Sci Transl Med. 2013; 5(197): 1–12. doi: 10.1126/scitranslmed.3006258
19. Unglaub S de. Fisiologi Manusia. Penerbit Buku Kedokteran EGC; 2013.
DOI: https://doi.org/10.22146/majkedgiind.80243
Article Metrics
Abstract views : 929
| 
views : 532
Refbacks
- There are currently no refbacks.
Copyright (c) 2023 Majalah Kedokteran Gigi Indonesia
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.