Unsuspected oral pigmentation in patient with systemic disease histories

https://doi.org/10.22146/majkedgiind.94667

Tjut Intan Permata Sari(1), Dewi Agustina(2*), Nathaniel Dean(3)

(1) Department of Oral Medicine, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
(2) Department of Oral Medicine, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
(3) Dental Study Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia
(*) Corresponding Author

Abstract


Oral pigmentation refers to a pigmented lesion on the oral mucosa, caused by one or more pigments that accumulate, resulting in tissue color change. Pigment lesions can vary in size, color, and location, and may range from benign to malignant. The role of the dentist is crucial in recognizing and classifying these lesions to facilitate proper treatment. This case report describes oral pigmentary abnormalities suspected to be indicative of an undiagnosed systemic disease. A 52-year-old woman presented with complaints of brittle teeth. Upon examination, changes in her oral mucosa were noted, and she was found to have uncontrolled type 2 diabetes mellitus, as well as a history of hysterectomy due to a tumor. Intraoral and extraoral examination revealed macular pigmentation on the mucosa and skin, particularly on the extremities. After further investigation, we concluded that early detection of polyps is important, as these patients may be susceptible to neoplasia development in areas outside the intestines. Dentists should be vigilant in recognizing a wide range of lesions that can assist in diagnosing conditions beyond oral health, to ensure patients receive appropriate treatment.


Keywords


diabetes mellitus; oral pigmentation; underlying disease

Full Text:

11. Tjut Intan


References

1. Roy R. Classification of oral pigmented lesions: A review. Int J Appl Dent Sci. 2019;
5(2): 397-402.

2. Tarakji B, Umair A, Prasad D, Altamimi MA. Diagnosis of oral pigmentations and malignant
transformations. Singapore Dent J. 2014; 35C: 39-46. doi: 10.1016/j.sdj.2014.03.001

3. Sreeja C, Ramakrishnan K, Vijayalakshmi D, Devi M, Aesha I, Vijayabanu B. Oral
pigmentation: A review. J Pharm Bioallied Sci. 2015; 7(Suppl 2): S403-S408.
doi: 10.4103/0975-7406.163471

4. Toedtling V, Crawford FC. Clinical and histopathological differential diagnosis of Laugier-Hunziker syndrome: An extremely rare case with unusual extensive oral hyperpigmentation. Clin Case Rep. 2020; 9(1): 303-313. doi: 10.1002/ccr3.3522

5. Sandru F, Petca A, Dumitrascu MC, Petca RC, Carsote M. Peutz-Jeghers syndrome:
Skin manifestations and endocrine anomalies (Review). Exp Ther Med. 2021; 22(6):1387. doi: 10.3892/etm.2021.10823

6. Grover Hs, Kapoor S, Kaushik N. Polycythemia vera dental management-case report. J Anesth Crit Care Open Access. 2016; 5(2): 00177. doi: 10.15406/jaccoa.2016.05.00177

7. Jalowiec KA, Vrotniakaite-Bajerciene K, Jalowiec J, Frey N, Capraru A, Wojtovicova T, Joncourt R, Angelillo-Scherrer A, Tichelli A, Porret NA, Rovó A. JAK2 unmutated polycythaemia-real-world data of 10 years from a tertiary reference hospital. J Clin Med. 2022; 11(12): 3393.
doi: 10.3390/jcm11123393

8. Madhavan, Alex TS, et al. Polycythemia vera: Gingival and periodontal manifestations and
management – A case report. IP International Journal of Periodontology and Implantology.
2022; 7(4): 196–198. doi: 10.18231/j.ijpi.2022.040

9. Yamamoto H, Sakamoto H, Kumagai H, Abe T, Ishiguro S, et al. Clinical guidelines for diagnosis and management of peutz-jeghers syndrome in children and adults. Digestion. 2023; 104(5): 335-347. doi: 10.1159/000529799

10. Choudhury S, Das A, Misra P, Ray U, Sarangi S. Peutz-Jeghers syndrome: a circumventable
emergency. Indian J Dermatol. 2018; 63(2): 168-171. doi: 10.4103/ijd.IJD_563_16

11. Mozaffari HR, Rezaei F, Sharifi R, Mirbahari SG. Seven-Year follow-up of peutz-jeghers
syndrome. Case Rep Dent. 2016. 2016: 6052181. doi: 10.1155/2016/6052181

12. Verhulst MJL, Loos BG, Gerdes VEA, Teeuw WJ. Evaluating all potential oral complications
of diabetes mellitus. Front Endocrinol (Lausanne). 2019; 10: 56.
doi: 10.3389/fendo.2019.00056

13. Mohsin SF, Ahmed SA, Fawwad A, Basit A. Prevalence of oral mucosal alterations in type 2 diabetes mellitus patients attending a diabetic center. Pak J Med Sci. 2014; 30(4):
716-719.

14. Hirota Y, Matsushita T. Hyperpigmentation as a clue to Addison disease. Cleve Clin J Med.
2022; 89(9): 498-499. doi: 10.3949/ccjm.89a.21082

15. Mehra A, Karjodkar F, Sansare K, et al. McCune-Albright syndrome with multiple oral
manifestations - a case report. Int J Health Sci Res. 2018; 8(2): 297-301.



DOI: https://doi.org/10.22146/majkedgiind.94667

Article Metrics

Abstract views : 1070 | views : 207

Refbacks

  • There are currently no refbacks.




Copyright (c) 2024 Majalah Kedokteran Gigi Indonesia

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


 

 View My Stats


real
time web analytics