1.png)
* Corresponding Author
Misdiagnose of fine needle aspiration biopsy
https://doi.org/10.22146/mkgk.49228 Rahma Yulinda Damanhuri(1*), Maria Goreti Widiastuti(2), Poerwati Soetji Rahajoe(3)
(1) Program Studi Ilmu Bedah Mulut dan Maksilofasial Program Pendidikan Dokter Gigi Spesialis, Fakultas Kedokteran Gigi, Universitas Gadjah Mada, Yogyakarta
(2) Poli Gilut RSUP Dr. Sardjito, Yogyakarta
(3) Departemen Bedah Mulut dan Maksilofasial, Fakultas Kedokteran Gigi, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author
Abstract
The accuracy of biopsy on oral malignant lesion examination depends on the adequacy of clinical information obtained, biopsy type and procedure, determination of biopsy site, and integrity of biopsy tissue. Fine needle aspiration biopsy (FNAB) is one of among cytology examination
that can be used for oral lesion. However, the results are variative, either false positive or false negative. The adequate management of a malignant lesion started with an accurate diagnosis. Histopathology and tissue biopsy examination is a gold standard in diagnosis determination of suspected malignant lesion. The aim of this case study was to report a refferal case of misdiagnosed lower lip squamous cell carcinoma using FNAB examination. Patient reffered from local hospital with squamous cell carcinoma lesion misdiagnosed as a benign cystic lesion prone to mucocele through FNAB finding. From this case study, it was concluded that FNAB examination is not reliable to diagnose superficial lesions, such as cystic lesions and SCC in the lower lip.
ABSTRAK
Ketepatan diagnosis dari pemeriksaan lesi ganas rongga mulut tergantung pada adekuatnya informasi klinis yang didapatkan, jenis dan prosedur biopsi yang tepat, pemilihan tempat biopsi dan pemenuhan syarat dari jaringan biopsi. Aspirasi jarum halus (AJH) merupakan salah satu pemeriksaan sitologi yang bisa dilakukan untuk lesi di mulut, namun hasil pemeriksaan AJH masih ada yang dilaporkan false negative maupun false positive dengan hasil yang bervariasi.
Penanganan yang tepat pada lesi ganas dimulai dengan melakukan diagnosis yang akurat. Standar baku dalam mendiagnosa terletak pada pemeriksaan histopatologi dari biopsi jaringan yang dicurigai mengalami lesi ganas. Tujuan studi kasus ini adalah melaporkan suatu kasus rujukan kesalahan diagnosis squamous cell carcinoma bibir bawah dengan pemeriksaan AJH. Seorang pasien rujukan dari salah satu RSUD dengan lesi squamous cell carcinoma yang
didiagnosis benigna cystic lesion yang condong ke mucocele melalui pemeriksaan AJH. Kesimpulan studi kasus ini adalah pemeriksaan AJH tidak tepat digunakan untuk kasus lesi superfisial seperti lesi kistik dan SCC di bibir bawah.
Keywords
Full Text:
PDFReferences
1. Sukardja IDG. Onkologi klinik. Surabaya: Airlangga University Press; 2000. 202-204.
2. Rosai J. Ackerman’s surgical pathology. Mosby. St. Louis; 1996. 6-10.
3. Avon SL, Hagen K. Oral soft-tissue biopsy: an overview. J Can Dent Assoc. 2012; 78(c75): 1-9.
4. Sakarwal N, Awasthi S, Dutta S Nizammudin S, Kumar A, Ahmad F, Vyas P. Fine needle aspiration cytology: a diagnostic tool for oral lesions. International Journal of Scientific Study. 2015; 3(2): 90-94.
5. Berwal V, Kiran S, Naik VG, Khandeparker RVS, Jain H. A review on oral mucosal biopsies with considerations on type of biopsy according to clinical diagnosis and handling of tissues. Journal of Advanced Medical and Dental Sciences Research. 2014; 2(3): 102-107.
6. Santos APC, Sugaya NN, Junior DSP, Junior CAL. Fine needle aspiration biopsy in the oral cavity and head and neck region. Braz Oral Res. 2011; 25(2): 186-191.
7. Thomson P. Precancer, diagnosis and management of potentially malignant disorders. Wiley Blackwell. New Castle Upon Tyne; 2012. 87.
8. Hasson O. Squamous cell carcinoma of the lower lip. J Oral Maxillofac Surg. 2008; 66: 1259-1262.
9. Govindrao A. Textbook of oral medicine. Unipress Medical Malaysia; 2007. 289-296.
10. Rethman MP, Carpenter W, Cohen EEW, Epstein J, Evans CA, Flaitz CM, Graham FJ, Hujoel PP, Kalmar JR, Koch WM, Lambert PM, Lingen MW, Oettmeier Jr BW, Patton LL, Perkinst D, Reid MW, Sciubba JJ, Tomar SL, Wyatt Jr AD, Aravamudhan K, Frantsve-Hawley J, Cleveland JL, Meyer DM. Evidencebased clinical recommendations regarding screening for oral squamous cell carcinomas. JADA. 2010; 141: 509-520.
11. Feller L, Lemmer J. Oral squamous cell carcinoma: epidemiology, clinical presentation and treatment. Journal of Cancer Therapy. 2012; 3: 263-268.
12. Hafez NH, Fahim MI. Diagnostic accuracy and pitfalls of fine needle aspiration cytology and scrape cytology in oral cavity lesions. Russian Open Medical Journal. 2014; 3: 0405: 1-8.
13. Singh S, Garg N, Gupta S, Marwah N, Kalra R, Singh V, Sen R. Fine needle aspiration cytology in lesions of oral and maxillofacial region: diagnostic pitfalls. Journal of Cytology. 2011; 28(3): 155-161.
14. Cankaya H, Guneri P, Epstein JB. Adjunctive methods and devices for clinical detection of oral squamous cell carcinoma. Oral Health and Preventive Dentistry; 2013. 1-11.
15. Fedele S. Diagnostic aids in the screening of oral cancer. Head & Neck Oncology. 2009; 30: 1-6.
16. Sciubba JJ. Improving detection of precancerous and cancerous oral lesions: computerassisted analysis of the oral brush biopsy. JADA; 1999: (130): 1445-1457.
17. Mehrotra R. Oral citology a concise guide. Springer; 2013. 11-24.
18. Wood NK and Goaz PW. Differential diagnosis of oral and maxillofacial lesions. Mosby; 1997. 10-12.
19. Peterson LJ, Ellies E, Hupp JK, and Tucker MR. Contemporery oral and maxillofacial surgery. Mosby. Toronto; 2003. 466-478.
20. Guneri P, Epstein JB, Kaya, A,Veral A, Kazandı A, Boyacioglu H. The utility of toluidine blue staining and brush cytology as adjuncts in clinical examination of suspicious oral mucosal lesions. Int J Oral Maxillofac Surg. 2011; 40: 155-161.
21. Gagan, SK, Manish S. Oral biopsy-revisited. Annals of Dental Research. 2011; 1(1): 44-53.
22. Scheifele C, Schmidt-Westhausen AM, Dietrich T, Reichart PA. The sensitivity and specificity of the OralCDX technique: evaluation of 103 cases. Oral Oncology. 2004; 40: 824-828.
23. Sheahan P, Fitzgibbon J, O’Leary G, Lee G. Efficacy and pitfalls of fine needle aspiration in the diagnosis of neck masses. Surg J R Coli Surg Edinb IreL. 2004; 2(3): 152-156.
24. Fragiskos. Oral Surgery. WB Saunders Co. Philadelpia; 2007. 281-298.
25. Poh, CF, Samson Ng, Berean KW, Williams PM, Rosin MP, Zhang L. Biopsy and histopathologic diagnosis of oral premalignant and malignant lesions. JCDA. 2008; 74(3): 285-288.
DOI: https://doi.org/10.22146/mkgk.49228
Article Metrics
Abstract views : 3382
| 
views : 11674
Refbacks
- There are currently no refbacks.
Copyright (c) 2019 MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.