The Kinetics of CD8+ T Lymphocytes in Dengue Patients in Yogyakarta

Loo Huai Na; Umi Solekhah Intansari; Ida Safitri Laksanawati

doi:10.22146/tmj.17127

The Kinetics of CD8+ T Lymphocytes in Dengue Patients in Yogyakarta

https://doi.org/10.22146/tmj.17127

Loo Huai Na⁽¹⁾, Umi Solekhah Intansari^(2*), Ida Safitri Laksanawati⁽³⁾

(1) Student of Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
(2) Department of Clinical Pathology, Dr. Sardjito Hospital, Yogyakarta, Indonesia
(3) Department of Pediatric, Dr. Sardjito Hospital, Yogyakarta. Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
(*) Corresponding Author

Abstract

ABSTRACT

Introduction: Dengue fever can be graded into dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The CD8+ T lymphocytes mediate antiviral activity by producing cytokines and directly destroyed the dengue virus infected cells. This study focuses in observing the kinetics of CD8+ T lymphocytes absolute and relative count in dengue patients.

Objectives: To observe the kinetics of CD8+ T lymphocytes absolute and relative count in dengue patients.

Methods: The research design used is a descriptive study. This research measures and observes the kinetics CD8+ T lymphocytes absolute and relative count from day 2 to day 7. The CD8+ T lymphocytes count was determined using flowcytometry. Data was analyzed using ANOVA and independent t test with p<0.05 considered as significant.

Results: The CD8+ T lymphocytes absolute count is low during the beginning of disease course and it gradually increases from day 2 to day 7. The CD8+ T lymphocytes relative count decreases from day 2 to day 3, and start to increase back from day 3 to day 7. There is no difference between the level of CD8+ T lymphocytes absolute count and relative count between DF and DHF patients.

Conclusion: There is an increase in CD8+ T lymphocytes absolute count and relative count in dengue patients. There is no difference between DF and DHF patients in CD8+ T lymphocytes absolute and relative count.

Keywords: dengue fever; dengue hemorrhagic fever; CD8+ T lymphocytes; absolute count; relative count.