Hepatoprotective Effect of Banana Peel Flour on Histological and Liver Function in Diabetic Rats

  • Herlin Ajeng Nurrahma Department of Physiology, Faculty of Medicine Universitas Sultan Agung Islamic, Jl. Raya Kaligawe Km.4 Semarang
  • Andreanyta Meliala Department of Physiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Farmako Street, Sekip Utara, Yogyakarta 55281, Indonesia https://orcid.org/0000-0001-7100-2191
  • Paramita Narwidina Clinical Nutrition Study Group, Yogyakarta, Indonesia Researcher in Clinical Nutrition Research Group, Yogyakarta 55133, Indonesia https://orcid.org/0000-0001-5977-0470
  • Sri Herwiyanti Department of Histology and Cell Biology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Farmako Street, Sekip Utara, Yogyakarta 55281, Indonesia
Keywords: diabetes mellitus, NAFLD, banana peel flour, liver function


In diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) is closely linked to hyperglycemia metabolism. This study aimed to find out how a banana peel supplemented diet affected histological and liver function changes in streptozotocin-induced diabetic rats. Vitamins, minerals, dietary fiber, antioxidants, and tryptophan are all contained in banana peel flour (BPF). Serotonin is a neurotransmitter that has been linked to depression and anxiety. This post-test-only control group study was conducted on twenty-five male Wistar rats which were separated into five groups with different treatments. Groups II to V were diabetic rats model groups that consumed standard diet mixed with BPF 0%, 5%, 10%, and 20%, respectively, while group I was a healthy control group fed a standard diet. Hepatic enzyme transaminase (Alanine Aminotransferase-ALT and Aspartate Aminotransferase - AST) and Hematoxylin-Eosin (HE) staining were analyzed with the NAFLD score to examine the liver function and hepatocellular morphology. A change in liver function was observed, as well as a substantial change in the levels of ALT and AST. The NAFLD score with HE staining showed substantial improvements in liver morphology, which was better seen at a 20% BPF dose. The current study supported the hypothesis that BPF had a hepatoprotective effect in diabetic rats, which may be due to the mechanism of controlling the hepatic enzyme transaminase and inducing liver regeneration.


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How to Cite
Nurrahma, H. A., Meliala, A., Narwidina, P., & Herwiyanti, S. (2021). Hepatoprotective Effect of Banana Peel Flour on Histological and Liver Function in Diabetic Rats. Indonesian Journal of Pharmacy, 32(4), 529-538. https://doi.org/10.22146/ijp.1917
Research Article