Evaluation of Hypertension-Related Knowledge, Medication Compliance, and Associated Factors Among Patients at Sukoharjo District Hospital, Central Java, Indonesia: A Cross-Sectional Study

Authors

  • Santi Dwi Astuti UGM
  • Agung Endro Nugroho Department of Pharmacology & Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada
  • Taslim Pinzon Department of Medical, Faculty of Medicine, Universitas Kristen Duta Wacana
  • Susi Ari Kristina Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada

DOI:

https://doi.org/10.22146/ijp.24973

Keywords:

Hypertension, Patient Knowledge, Medication Adherence, Sociodemographic Determinants, Public Hospital, Indonesia

Abstract

Suboptimal blood pressure control among hypertensive patients is often attributed to inadequate knowledge and poor adherence to antihypertensive medication. Understanding how sociodemographic factors influence these variables is essential for optimizing chronic disease management, particularly in regional healthcare settings. To examine the associations between patient sociodemographic characteristics, hypertension-related knowledge, and medication adherence among outpatients at a public regional hospital in Sukoharjo, Central Java, Indonesia. This cross-sectional study included 702 hypertensive patients attending RSUD Sukoharjo. The Hypertension Knowledge Level Scale (HKLS) and Morisky Green Levine Scale (MGLS) were used to assess knowledge and adherence, respectively. Instrument validity and reliability were evaluated using Pearson correlation and Cronbach’s alpha. Associations between demographic variables and outcomes were analyzed using chi-square tests. The results Both HKLS and MGLS demonstrated good validity (r = 0.429–0.602 and 0.584–0.621) and internal consistency (Cronbach’s alpha = 0.872 and 0.743). Most patients exhibited moderate knowledge (49.7% correct responses) and moderate adherence (86.3%). Significant associations were found between knowledge level and age (p = 0.015), education (p < 0.001), and smoking status (p = 0.041). Similarly, adherence was significantly associated with age (p = 0.022), education (p < 0.001), and smoking behavior (p = 0.008). Age, educational attainment, and smoking behavior are significantly associated with patient knowledge and medication adherence in hypertension management. These findings highlight the need for targeted strategies to improve health literacy and adherence behaviors, particularly in regional and resource-limited healthcare settings.

References

Abegaz, T. M., Shehab, A., Gebreyohannes, E. A., Bhagavathula, A. S., & Elnour, A. A. (2017). Nonadherence to antihypertensive drugs: A systematic review and meta-analysis. Medicine, 96(4), e5641. https://doi.org/10.1097/MD.0000000000005641
Ali, M., Alam, K., Ali, N., Shahrir, M. S., et al. (2019). Factors associated with medication adherence among hypertensive patients in Pakistan. PLoS ONE, 14(10), e0223543. https://doi.org/10.1371/journal.pone.0223543
Almas, A., Hameed, A., Ahmed, B., & Islam, M. (2012). Compliance to antihypertensive therapy. Journal of Ayub Medical College Abbottabad, 24(3–4), 51–54.
Amoah, A. O., Addo, B., Owusu-Ansah, M., & Appiah-Kubi, S. (2022). Hypertension-related knowledge and adherence among hypertensive patients in rural Ghana. BMC Public Health, 22, 1417. https://doi.org/10.1186/s12889-022-13764-6
Berhe, H., Bayray, A., & Teklay, H. (2021). Knowledge, attitude and practice of hypertensive patients in Tigray, Ethiopia. International Journal of Hypertension, 2021, 1–8. https://doi.org/10.1155/2021/5572027
Bujang, M. A., & Adnan, T. H. (2016). Requirements for minimum sample size for sensitivity and specificity analysis. Journal of Clinical and Diagnostic Research, 10(10), YE01–YE06. https://doi.org/10.7860/JCDR/2016/18129.8744
Burnier, M., & Egan, B. M. (2019). Adherence in hypertension. Circulation Research, 124(7), 1124–1140. https://doi.org/10.1161/CIRCRESAHA.118.313220
Centers for Disease Control and Prevention. (2020). Tobacco use and cessation. https://www.cdc.gov/tobacco/index.htmErci, B., Yildiz, F. T., & Sayan, A. (2012). Determination of hypertension knowledge level scale. International Journal of Caring Sciences, 5(3), 235–242.
Hossain, M. M., Arafat, S. M. Y., & Islam, M. S. (2021). Health literacy and medication adherence in hypertensive patients: A cross-sectional study in a Bangladeshi rural setting. BMJ Open, 11, e043813. https://doi.org/10.1136/bmjopen-2020-043813
Indonesian Ministry of Health. (2019). Hasil Riskesdas 2018: Laporan Nasional. Jakarta: Badan Litbangkes.
Khatib, R., Schwalm, J. D., McKee, M., & Yusuf, S. (2023). Adherence to antihypertensive therapy worldwide: A systematic review and meta-analysis. The Lancet Global Health, 11(3), e430–e440. https://doi.org/10.1016/S2214-109X(23)00011-1
Krousel-Wood, M., Islam, T., Webber, L. S., Re, R. N., Morisky, D. E., & Muntner, P. (2009). New medication adherence scale versus pharmacy fill rates in seniors with hypertension. The American Journal of Managed Care, 15(1), 59–66.
Lim, H. M., Lee, P. Y., & Ng, C. J. (2019). A systematic review on the effectiveness of health education interventions to improve adherence to antihypertensive medications among patients with hypertension. PLoS ONE, 14(10), e0223482. https://doi.org/10.1371/journal.pone.0223482
Morisky, D. E., Green, L. W., & Levine, D. M. (1986). Concurrent and predictive validity of a self-reported measure of medication adherence. Medical Care, 24(1), 67–74. https://doi.org/10.1097/00005650-198601000-00007
Nunnally, J. C., & Bernstein, I. H. (1994). Psychometric theory (3rd ed.). New York: McGraw-Hill.
Nutbeam, D. (2008). The evolving concept of health literacy. Social Science & Medicine, 67(12), 2072–2078. https://doi.org/10.1016/j.socscimed.2008.09.050
Osterberg, L., & Blaschke, T. (2005). Adherence to medication. The New England Journal of Medicine, 353(5), 487–497. https://doi.org/10.1056/NEJMra050100
Sabaté, E. (2003). Adherence to long-term therapies: Evidence for action. Geneva: World Health Organization.
Tumanan-Mendoza, B. A., Mendoza, V. L., & Sy, R. G. (2020). Hypertension awareness, treatment and control and associated factors: A population-based study in the Philippines. Journal of Clinical Hypertension, 22(12), 2248–2256. https://doi.org/10.1111/jch.14090
World Health Organization. (2021). Hypertension fact sheet. https://www.who.int/news-room/fact-sheets/detail/hypertension
World Medical Association. (2013). Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA, 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053

Published

2026-07-23

How to Cite

Dwi Astuti, S., Nugroho, A. E. ., Taslim Pinzon, R. ., & Ari Kristina, S. . (2026). Evaluation of Hypertension-Related Knowledge, Medication Compliance, and Associated Factors Among Patients at Sukoharjo District Hospital, Central Java, Indonesia: A Cross-Sectional Study. Indonesian Journal of Pharmacy. https://doi.org/10.22146/ijp.24973

Issue

Section

Research Article

Most read articles by the same author(s)