Somatostatin Analog-Based Radiopharmaceuticals for Molecular Imaging and Therapy of Neuroendocrine Tumors

  • Rien Ritawidya National Research and Innovation Agency Republic Of Indonesia. Address: B.J. Habibie Building 15th-24th floor, Jl. M.H. Thamrin No. 8, Jakarta Pusat 10340
  • Citra Rezza Aurora Putri Palangka Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine
  • Titis Sekar Humani National Research and Innovation Agency Republic Of Indonesia. Address: B.J. Habibie Building 15th-24th floor, Jl. M.H. Thamrin No. 8, Jakarta Pusat 10340
  • Veronika Yulianti Susilo National Research and Innovation Agency Republic Of Indonesia. Address: B.J. Habibie Building 15th-24th floor, Jl. M.H. Thamrin No. 8, Jakarta Pusat 10340
  • Ilma Darojatin National Research and Innovation Agency Republic Of Indonesia. Address: B.J. Habibie Building 15th-24th floor, Jl. M.H. Thamrin No. 8, Jakarta Pusat 10340
  • Anung Pujiyanto National Research and Innovation Agency Republic Of Indonesia. Address: B.J. Habibie Building 15th-24th floor, Jl. M.H. Thamrin No. 8, Jakarta Pusat 10340
Keywords: somatostatin, peptide, radiopharmaceuticals, therapy, imaging


Somatostatin receptors (SSTRs) are overexpressed in a wide variety of cancers such as neuroendocrine tumors (NETs), but the expression in normal cells is relatively low. Therefore, SSTRs serve a potential target for molecular imaging and therapeutic applications of NETs. This review presents the development of somatostatin analog-labeled with gamma-emitting radionuclides such as 111In, 99mTc, and 123I for the visualization of NETs via single-photon emission tomography (SPECT). Additionally, the development of somatostatin analog-radiolabeled with positron emitting radionuclide such as 68Ga for the molecular imaging of NETs with positron emission tomography (PET) is also presented herein. Moreover, this review describes 177Lu-, 90Y-, and 111In-labeled somatostatin analogs as peptide receptor radionuclide therapy (PRRT) agents for the therapeutic application of NETs. These radiolabeled-somatostatin analogs showed promising results with good images quality and high tumor uptake. These results highlight the potential application of radiopharmaceuticals-based somatostatin analogs for the molecular imaging and targeted treatment of NETs.


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How to Cite
Ritawidya, R., Palangka, C. R. A. P., Humani, T. S., Susilo, V. Y., Darojatin, I., & Pujiyanto, A. (2022). Somatostatin Analog-Based Radiopharmaceuticals for Molecular Imaging and Therapy of Neuroendocrine Tumors. Indonesian Journal of Pharmacy, 33(3), 333-352.
Review Article