Optimization of Gelling Agent and Sunscreen Activity Test of 4-OH-chalcone Gel by In Vitro Method

  • Abdul Karim Zulkarnain Faculty of Pharmacy UGM
  • Jumina Jumina Uninersitas Gadjah Mada
  • Galih Titiasari Kharismawati Faculty of Pharmacy, Universitas Gadjah Mada, Skip Utara 55281 Yogyakarta
  • Fina Anjani Larasati Faculty of Pharmacy, Universitas Gadjah Mada, Skip Utara 55281 Yogyakarta
Keywords: gel, 4-OH-chalcone,, SLD, SPF



The 4-OH-chalcone was suspected to absorb and reduce ultraviolet radiation intensity that exposed to the skin. The 4-OH-chalcone was formulated as gel dosage form using combination of carbopol in content of 0.50-1.00% w/w; propylene glycol in content of 19-20% w/w; and CMC-Na in content of 0.50-1.00% w/w. This study’s purpose was to optimize the three gel bases, evaluate physical properties, physical stability, and activity of 4-OH-chalcone gel as sunscreen by in vitro method. Simplex Lattice Design (SLD) method was used to optimize gel base with Design Expert software version 10.0. Activity of 4-OH-chalcone gel as sunscreen was determined spectrophotometrically by determining Sun Protecting Factor (SPF) value, percent transmission of erythema (% TE), and percent transmission of pigmentation (% TP). Data were analyzed statistically with SPSS Statistic software. Optimum formula of 4-OH-chalcone gel with 0.50% w/w carbopol content, 0.50% w/w carboxymethylcellulose sodium content, and 20,0% w/w propylene glycol content has pH of 5.59, viscosity of 37.4 dPa.s, spreadability of 28.8 cm2, adhesive time of 1.28 seconds, SPF value of 28.65, %, TE value of 16.44%, %TP value of 0.24%, and relatively stable physical properties.

Author Biography

Jumina Jumina, Uninersitas Gadjah Mada

Department of Chemistry, Faculty of Mathematic and Natural Science, University of Gadjah Mada Yogyakarta


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How to Cite
Zulkarnain, A. K., Jumina, J., Kharismawati, G. T., & Larasati, F. A. (2023). Optimization of Gelling Agent and Sunscreen Activity Test of 4-OH-chalcone Gel by In Vitro Method. Indonesian Journal of Pharmacy, 34(1), 112-119. https://doi.org/10.22146/ijp.3300
Research Article