Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides

  • Volodymyr Ya Horishny Department of Pharmaceutical, Organic and Bioorganic Chemistry Danylo Halytsky Lviv National Medical University, Lviv, 79010, Ukraine
  • Iryna V Drapak Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine
  • Taras I Chaban Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine
  • Yuriy V Ostapiuk Department of Organic Chemistry, Ivan Franko National University of Lviv, 6 Kyryla і Mefodia, Lviv, 79005, Ukraine
  • Vasyl S Matiychuk Department of Organic Chemistry, Ivan Franko National University of Lviv, 6 Kyryla і Mefodia, Lviv, 79005, Ukraine
Keywords: organic synthesis, thiazole, imidazole, anticancer activity


New N-(5-R-benzyl-1,3-thiazol-2-yl)-2-morpholin-4-yl-2-oxoacetamides have been prepared in good yields via the reaction of N-(5-R-benzyl-1,3-thiazol-2-yl)-2-chloroacetamides with sulfur and morfoline. These compounds react with ethendiamine to form a series of novel N-[5-R-benzyl)-1,3-thiazol-2-yl]-4,5-dihydro-1H-imidazole-2-carboxamides with excellent yields. Anticancer activity screening of synthesized compounds was carried out within the framework of the Developmental Therapeutic Program of the National Cancer Institute's (DTP, NCI, Bethesda, Maryland, USA). It was shown that compounds are promising for new anticancer agents' search.


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How to Cite
Ya Horishny, V., V Drapak, I., I Chaban, T., V Ostapiuk, Y., & S Matiychuk, V. (2020). Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides. Indonesian Journal of Pharmacy, 31(3), 150-160.
Research Article