Nyi Mekar Saptarini(1*), Dadan Suryasaputra(2), Atep Misbah Saepulhak(3)

(1) Faculty of Pharmacy, Universitas Padjajaran
(2) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Al Ghifari
(3) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Al Ghifari
(*) Corresponding Author


Peptic ulcer were been caused by an imbalance between the aggressive factors and a number of defense mechanisms. Pepino (Solanum muricatum Aiton) fruit predicted had antiulcer activity. This study is aimed to test the antiulcer activity of pepino fruit juice in Swiss-Webster mice model which induced by 50 µL concentrated acetic acid. The steps in this study consist of making of fruit juice, phytochemical screening, testing of antiulcer activity at 300, 500, dan 800 µL/20 g BW in doses, and data analyzed using ANOVA. The concentration of pepino fruit juice was 2.5 g/mL. Phytochemical screening showed that pepino fruit juice contain alkaloids, flavonoids, and tannins with protection ratio were 6.02, 23.15, and 63.29% at 300, 500, dan 800 µL/20 g BW, respectively.


Pepino dulce, Fruit juice, Peptic ulser, Antiulcer, Animal experimental model


Ahumada, M. and Cantwell, M. 1996. Postharvest Studies on Pepino Dulce (Solanum muricatum Ait.): Maturity at Harvest and Storage Behavior. Elsevier. Postharvest Biology and Technology 7: 129-136

Alarcon de la Lastra A.C., Martin M.J., and Motilva, V. 1995. Gastroprotection induced by silymarin, the hepatoprotective principle of Silybum marianum in ischemia-reperfusion mucosal injury: role of neutrophils. Planta Med 61 (20): 116-119

Annamalai, A.R. and Manavalan, R. 1990. Effects of Trikatu and its individual components and piperine on gastrointestinal tract: Trikatu - a bioavailable enhancer. Indian Drugs 27, 595-604

Bagchi, D., Ray, S.D., Bagchi, M., Preuss, H.G., and Stohs, S.J. 2002. Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. Indian J Exp Biol 40(6): 717-726

Bai, Y.F. and Xu, H. 2000. Protective action of piperine against experimental gastric ulser. Acta Pharmacol.Sin. 21, 357-359

Bandyopadhyay, D., Biswas, K., Bhattacharyya, M., Reiter, R.J., and Banerjee, R.K. 2001. Gastric Toxicity and Mucosal Ulseration Induced by Oxygen-Derived Reactive Species: Protection by Melatonin.Curr. Mol. Med. 1: 501-513

Cho, C.H. and Wang J.Y. 2002. Gastointestinal Mucosal Repair and Experimental Therapeutics. Frontiers of Gastrointestinal Res, Basel. Karger, 25, p 251

Cho, C.H. and Wang J.Y. 2002. Gastointestinal mucosal repair and experimental therapeutics. Frontiers of Gastrointestinal Res, Basel. Karger, p 251

Dennis, D.J., Burge, G.K. and Lill, R. 1985. Pepinos:Cultural Techniques. Information Services, Ministry of Agriculture, Wellington, N.Z., p. 2

Esaki N., Kato M., Takizawa N., Morimoyo S., Nonaka G., and Nishioca I. 1986. Pharmacological studies on Linderae umbellate Ramus. IV. Effects of condensed tannin related compounds on pepitic acitivity and stressinduced gastric lesions in mice. Planta Med 1: 34-38

Fallone, C.A. and Morris, G.P. 1995. Topical nicotine protects rat gastric mucosa against ASA-induced damage. A role for mucosal fluid secretion in cytoprotection. Digest. Dis. Sci. 40, 936-942

Goel R.K., Chakraborti A., and Sanyal A.K. 1985. The effect of biological variable on the anti ulcerogenic effect of vegetable planta in banana. Planta Med. 2: 85-88

Harman, J.E., Hogg, M. and Horne, S.F. 1986. Maturity and Quality Indices for Pepino Fruit. HortScience, 21(3): 129 (abstract)

Kaunitz, J.D. and Akiba, Y. 2004. Gastroduodenal Mucosal Defense: Role of Endogenous Mediators. Curr.Opin. Gastroenterol. 20, 526-532

Kim S.C., Byun S.H., and Yang C.H. 2004. Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage). Toxicology 197(3): 239-251

Konturek, P.C., Konturek, S.J., Majka, J., Zembala, M., and Hahn, E.G. 1997. Melatonin affords protection against gastric lesions induced by ischemia-reperfusion possibly due to its antioxidant and mucosal microcirculatory effects. Eur. J. Pharmacol. 322, 73-77

Kyogoku, K., Hatayama, K., and Yokomori, S. 1979. Anti-ulser effect of isoprenyl flavonoids. II. Synthesis and anti-ulser activity of new chalcones related to sophoradin. Chem Pharm Bull 1979; 27: 2943-2952

Liu, C.F., Lin, C.C., Lin, M.H., Lin, Y.S., and Lin, S.C. 2002. Cytoprotection by propolis ethanol extract of acute absolute ethanol-induced gastric mucosal lesions. Am J Chin Med 30(2-3): 245-254

Mills, S. and Bone, K. 2000. Principles and Practice of Phytotherapy Modern Herbal Medicine, Churchill: Livingstone, p. 161-176, 396

Omoto, T., Shinho, Y., Nakajima, K., Ishiwatari, H., and Ito, H. 1990. Antiulser alkaloids from Picrasma ailanthus. Jpn Kokai Tokyo Koho 02004790

Pastrada-Bonilla, E., Akoh, C.C., Sellappan, S., and Krewer, G. 2003. Phenolic content and antioxidant capacity of muscadine grapes. J Agric Food Chem 51(18): 5497-5503

Prohens, J., Ruiz, J.J. and Nuez, F. 2000. Growing Cycles for a New Crop, the Pepino, in the Spanish Mediterranean. Acta Horticulturae 523: 53–60

Redgwell, R.J. and Turner, N.A., 1986. Pepino (Solanum muricatum): Chemical Composition of Ripe Fruit. J. Sci. Food Agric., 37: 1217-1222

Tan, P.V., Nyasse, B., Dimo, T., Wafo, P., and Akahkuh, B.T. 2002. Synergistic and potentiating effects of ranitidine and two new anti-ulser compounds from Enantia chlorantha and Voacanga africana in experimental animal models. Pharmazie 57, 409-412

Tan, P.V.; Nyasse, B.; Enow-Orock, G.E.; Wafo, P.; Forcha, E.A. 2000. Prophylactic and healing properties of a new anti-ulser compound from Enantia chlorantha in rats. Phytomedicine 7, 291-296

Tani, S. 1976. Effect of tannic acid and taic acid atarch on the experimental gastric ulser in rats. J. Pharm. Soc. Jpn 96: 648-652

Tarnawski, A.S. 2005. Cellular and Molecular Mechanisms of Gastrointestinal Ulser Healing. Digest. Dis.Sci., 50, 24-33

Wan, Y.J. 1993. Effect of anisodamine on gastric ulser induced by restraint water-immersion in rats. Clin. Gastroenterol. 3, 154-158

Wang, J.L. 2000. Effect of anisodamine on the reserpine-induced gastric mucosal lesion in rats. Zhongguo Bingli Shengli Zazhi 16, 237-242

Weinges, K., 1967. Carbohydrate Content and Sucrose Metabolism (Phytochemistry in Developing Solanum muricatum Aiton Fruits), Tetrahedrun Letter, 737-740

Weiss, R.F. and Fintelmann, V. 2000. Herbal Medicine, Thiene Stugart: NY, 65-70

Yamahara, J., Mohizuki, M., Huang Qi Roang H., and Fuzimura. 1988. The Antiulser Effect in Rats of Ginger Constituent. Journal of Ethopharmacology, 7: 299-304

Yamazaki, M. and Shirota, H. 1981. Application of experimental stress ulser test in mice for the survey of neurotropic naturally occurring drug materials. Shoyakugaku Zasshi 35, 96-102

Yong, D.G., Geng, B.Q., Gu, G.G., Zhong, F.M., and Yu, W.H. 1991. Anti-ulser effect of anisodamine in rats. Acta Pharmacol. Sin. 12, 522-525

Zhang, J.F., Yan, C.D., Zhang, Y.Q., Gao, W.Z., and Zhai, X.M. 1990. Effect of scopolia drugs on the gastric mucosal lesion in rats. Acta Pharmacol. Sin. 25, 90-94

Zhu, Z.P., Zhang, M.F., and Shen, Y.Q. 1993. Antiulser components of Sophora viciifolia alkaloids. Tianran Chanwu Yanjiu Yu Kaifa 5, 26-29


Article Metrics

Abstract views : 1581 | views : 3828


  • There are currently no refbacks.

Copyright (c) 2015 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada