Gambaran Kadar Bilirubin Total pada Penderita Tuberkulosis Paru dengan Terapi Obat Anti Tuberkulosis (Oat) di Puskesmas Poasia Kota Kendari

https://doi.org/10.22146/jkesvo.44487

Firdayanti Firdayanti(1*)

(1) Politeknik Bina Husada Kendari
(*) Corresponding Author

Abstract


Background: Treatment of tuberculosis by using anti-tuberculosis drugs (OAT) can be accepted in therapy, but has potential effectiveness such as side effects of hematologic reactions, namely anemia, agranulocytosis, eosinophilia and thrombocytopenia, and liver function. Hyperbilirubinemia is one of the side effects of using OAT which is often complained by patients.

Objective: to determine the description of total bilirubin levels in tuberculosis patients with OAT therapy at the Poasia Health Center in Kendari City

Method: This study was descriptive with bilirubin examination using the Jendrassik-Grof method by spectrophotometer. Total bilirubin examination was performed on 18 pulmonary tuberculosis patients who received OAT therapy at the Poasia Health Center in Kendari City.

Results: The results of the study showed that from 18 samples examined, there were 10 samples with high bilirubin levels (hyperbilirubinemia) and 8 samples had normal bilirubin levels.

Conclusion: Total bilirubin levels in patients with pulmonary tuberculosis with OAT therapy were found as many as 10 patients had high bilirubin levels (hyperbilirubinemia) and 8 patients had normal bilirubin levels.


 

Keywords: Bilirubin, Hyperbilirubinemia, OAT, Therapy, Tuberculosis


Keywords


Analis Kesehatan; Bilirubin; Hyperbilirubinemia; OAT; Therapy; Tuberculosis

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References

Desrochers, D. et al. (2011) ‘Isoniazid-induced severe hepatotoxicity: an infrequent but preventable cause of liver failure in children treated for latent tuberculosis infection’, Clinical Medicine Insights: Pediatrics. SAGE Publications Sage UK: London, England, 5, p. CMPed-S6406. Ilmiah, K. T. et al. (2016) ‘BULAN KE II DAN AKHIR BULAN KE VI DI RSUD CIAMIS TAHUN 2016 PROGRAM STUDI D3 ANALIS KESEHATAN SEKOLAH TINGGI ILMU KESEHATAN MUHAMMADIYAH’. Kato, H. et al. (2013) ‘Risk factors for liver injury with an elevated serum bilirubin concentration caused by antituberculous drugs’, Internal medicine. The Japanese Society of Internal Medicine, 52(19), pp. 2209–2214. Kementerian Kesehatan, R. I. (2015) ‘Data dan Informasi Tahun 2014 (Profil Kesehatan Indonesia)’, Jakarta: Kementerian Kesehatan Republik Indonesia. Kosasih, E. N. and Kosasih, A. S. (2008) ‘Tafsiran hasil pemeriksaan laboratorium klinik’, Tangerang: Karisma Publishing Grup. Makay, F., Rambert, G. I. and Wowor, M. F. (2017) ‘Medical Laboratory Technology’, 3(2), pp. 42–46. Pontoh, L. G., Polii, E. B. I. and Gosal, F. (2016) ‘Gambaran bilirubin dan urobilinogen urin pada pasien tuberkulosis paru’, 4, pp. 0–5. Thuraidah, 2017 (2016) ‘Gambaran kadar bilirubin pasien tuberkulosis paru selama pengobatan di RSUP Prof . Dr . R . D . Kandou Manado’, 4(April). Wong, R. J. et al. (2007) ‘Neonatal Jaundice : Bilirubin Physiology and Clinical Chemistry Neonatal Jaundice : Bilirubin Physiology and Clinical Chemistry The online version of this article , along with updated information and services , is located on the World Wide Web at ’:, (October 2015). doi: 10.1542/neo.8-2-e58. Zumla, A. et al. (2015) ‘The WHO 2014 global tuberculosis report—further to go’, The Lancet Global Health. Elsevier, 3(1), pp. e10–e12.



DOI: https://doi.org/10.22146/jkesvo.44487

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