Translation and Validation of the Indonesian Version of Oral Chemotherapy Adherence Scale (OCAS)

https://doi.org/10.22146/jmpf.105128

Atika Wahyu Puspitasari(1*), Susi Ari Kristina(2), Satibi Satibi(3), Yayi Suryo Prabandari(4)

(1) Clinical Pharmacy and Pharmacy Practice Research Cluster, Faculty of Pharmacy, Universitas Indonesia, Jakarta
(2) Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(3) Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(4) Department of Public Health, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Background: Medication adherence is essential for oral anticancer agents (OAAs) to succeed and maintain the optimal therapeutic outcomes. However, there are no well-established instruments in Indonesia to evaluate adherence to oral chemotherapy by cancer patients.

Objectives: This study aimed to validate and translate the Oral Chemotherapy Adherence Scale (OCAS) for cancer patients in Indonesia.

Methods: Data were collected from patients taking oral chemotherapy for at least a month at Dharmais Cancer Hospital in Jakarta. OCAS was translated into Indonesian using a forward-backward translation method. Content validity was assessed through expert review to calculate Content Validity Index (CVI), while face validity was evaluated to confirm cultural relevance and readability. Internal consistency was measured using Cronbach's alpha.

Results: A total of 131 patients participated from August to December 2021. Content validation by seven experts showed that the mean I-CVI of the items was above 0.79, with an S-CVI of 0.985, reflecting the validity of the items. Furthermore, face validity confirmed the readability and clarity of Indonesian version of OCAS. Reliability testing showed a Cronbach alpha of 0.871, suggesting strong internal consistency.

Conclusion: Indonesian OCAS was a valid instrument for evaluating medication adherence in Indonesian cancer patients taking oral chemotherapy. Therefore, it can be used for adherence monitoring in healthcare settings.


Keywords


Adherence; Indonesia; Oral chemotherapy; Translation; Validation

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References

  1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020 : GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. 2021;0(0):1-41. doi:10.3322/caac.21660
  2. Bassan F, Peter F, Houbre B, et al. Adherence to oral antineoplastic agents by cancer patients: Definition and literature review. Eur J Cancer Care (Engl). 2014;23(1):22-35. doi:10.1111/ecc.12124
  3. McCue DA, Lohr LK, Pick AM. Improving adherence to oral cancer therapy in clinical practice. Pharmacotherapy. 2014;34(5):481-494. doi:10.1002/phar.1399
  4. Partridge AH, Avorn J, Wang PS, Winer EP. Adherence to therapy with oral antineoplastic agents. J Natl Cancer Inst. 2002;94(21):1652.
  5. Wood L. A review on adherence management in patients on oral cancer therapies. Eur J Oncol Nurs. 2012;16(4):432-438. doi:10.1016/j.ejon.2011.10.002
  6. Badawy SM, Barrera L, Sinno MG, Kaviany S, O’dwyer LC, Kuhns LM. Text messaging and mobile phone apps as interventions to improve adherence in adolescents with chronic health conditions: A systematic review. JMIR mHealth uHealth. 2017;5(5):1-17. doi:10.2196/mhealth.7798
  7. Spoelstra SL, Given CW. Assessment and Measurement of Adherence to Oral Antineoplastic Agents. Semin Oncol Nurs. 2011;27(2):116-132. doi:10.1016/j.soncn.2011.02.004
  8. Greer JA, Amoyal N, Nisotel L, et al. A Systematic Review of Adherence to Oral Antineoplastic Therapies. Oncologist. 2016;21(3):354-376. doi:10.1634/theoncologist.2015-0405
  9. Ahmed S, Bridar S, Ahmed A, Halcher S. Role of Clinical Pharmacist in Improving of Medication Adherence and Quality of Life in Chronic Disease Patients: A Brief Overview. Acta Sci Pharm Sci. 2022;6(7):30-36. doi:10.31080/asps.2022.06.0884
  10. Peng Q, Wu W. Development and validation of oral chemotherapy self-management scale. BMC Cancer. 2020;20:7. doi:10.1186/s12885-020-07404-0
  11. Bagcivan G, Akbayrak N. Development and Psychometric Testing of the Turkish-Version Oral Chemotherapy Adherence Scale. J Nurs Res. 2015;23(4):243-251. doi:10.1097/JNR.0000000000000101
  12. Lessa PRA, Ribeiro SG, Aquino P de S, de Almeida PC, Pinheiro AKB. Validation of the Adherence Determinants Questionnaire scale among women with breast and cervical cancer. Rev Lat Am Enfermagem. 2015;23(5):971-978. doi:10.1590/0104-1169.0222.2638
  13. Polit DF, Beck CT. The Content Validity Index: Are You Sure You Know What’s Being Reported? Critique and Recommendations. Res Nurs Health. 2006;29:488-495. doi:10.1002/nur
  14. Saiful M, Yusoff B, Resilience P. ABC of Content Validation and Content Validity Index Calculation. Resources. 2019;11(2):49-54. doi:10.21315/eimj2019.11.2.6
  15. Taber KS. The Use of Cronbach’s Alpha When Developing and Reporting Research Instruments in Science Education. Res Sci Educ. 2018;48(6):1273-1296. doi:10.1007/s11165-016-9602-2
  16. Taherdoost H. Validity and Reliability of the Research Instrument; How to Test the Validation of a Questionnaire/Survey in a Research. Int J Acad Res Manag. 2016;5(3):28-36.
  17. Connell J, Carlton J, Grundy A, et al. The importance of content and face validity in instrument development: lessons learnt from service users when developing the Recovering Quality of Life measure (ReQoL). Qual Life Res. 2018;27(7):1893-1902. doi:10.1007/s11136-018-1847-y
  18. Colombo LRP, Aguiar PM, Lima TM, Storpirtis S. The effects of pharmacist interventions on adult outpatients with cancer: A systematic review. J Clin Pharm Ther. 2017;42(4):414-424. doi:10.1111/jcpt.12562
  19. Puts MTE, Tu HA, Tourangeau A, et al. Factors influencing adherence to cancer treatment in older adults with cancer: A systematic review. Ann Oncol. 2014;25(3):564-577. doi:10.1093/annonc/mdt433
  20. Puspitasari AW, Kristina SARI, Prabandari YS. Overview of Adherence and Influencing Factors to Capecitabine In Cancer Patients : Systematic Review. Int J Pharm Res. 2021;13(1):3106-3118.



DOI: https://doi.org/10.22146/jmpf.105128

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