* Corresponding Author
The Correlation of Treatment Adherence with Clinical Outcome and Quality of Life in Patients with Type 2 Diabetes
https://doi.org/10.22146/jmpf.42927 Syaiful Katadi(1*), Tri Murti Andayani(2), Dwi Endarti(3)
(1) Graduate Program of Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author
Abstract
Patients with diabetes mellitus (DM) are patients with a low level of treatment adherence. Low adherence is often the cause of treatment failure, so the risk of complications is higher and can affect the quality of life of patients. This study aimed to determine the relationship between treatment adherence to clinical outcomes and the quality of life of patients with type 2 DM. This study used a cross sectional design involving patients with type 2 DM who met the inclusion and exclusion criteria in three health centers in Bantul, Yogyakarta. Data on patient medication compliance was obtained using medication adherence report scale questionnaire (MARS-5), patient quality of life data using Short-Form 6 Dimensions questionnaire (SF-6D), data on fasting blood glucose levels (GDS / GDP) from medical records, socio demographic data obtained from respondents and medical records. The relationship between the level of adherence to clinical outcomes using Chi-square analysis while the relationship between the level of adherence to quality of life using Spearman Rho analysis. The total number of respondents involved was 179 patients, the majority had a low level of adherence (57%), clinical outcomes that had not been achieved (68.7%), and the average utility score was high (0.816). There was a relationship between medication adherence to clinical outcomes (P = 0.002; OR = 2.875). Similarly, between adherence to quality of life, there is a significant relationship (P = 0.006) with a weak correlation level (r = 0.204). Therefore, patients and Health professionals, especially pharmacists, need to pay attention to medication adherence to achieve optimal clinical outcomes and a better quality of life.
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1. Kemenkes RI. Hasil Utama Riskesdas 2018. Kementerian Kesehatan Badan Penelitian dan Pengembangan Kesehatan. 2018;248.
2. American Diabetes Association. Standards of Medical Care in Diabetes-2018 Abridged for Primary Care Providers. Clin Diabetes. 2018;36(1):14-37.
3. Strand BH, Langballe EM, Hjellvik V et al., Midlife Vascular Risk Factors and Their Association with Dementia Deaths: Results From A Norwegian Prospective Study Followed Up For 35years. Journal of the Neurological Sciences. 2013;324(1):124-130.
4. Rasdianah N, Martodiharjo S, Andayani TM, Hakim L. The Description of Medication Adherence for Patients of Diabetes Mellitus Type 2 in Public Health Center Yogyakarta. Indonesian Journal of Clinical Pharmacy. 2016;5(4):249-257.
5. Srikartika VM, Cahya AD, Hardiati RSW. Analisis Faktor Yang Memengaruhi Kepatuhan Penggunaan Obat Pasien Diabetes Melitus Tipe 2. Jurnal Manajemen dan Pelayanan Farmasi. 2016;6:8.
6. Kubais MNA, Hassan2 NAGM, Shamsain2 MH. Association Between Adherence to Diabetes Medication and Glycemic Control. International Journal of Research and Development in Pharmacy and Life Sciences. 2015;5(1):1915-1920.
7. Mulyani R. Hubungan Kepatuhan Dengan Keberhasilan Terapi Berbasis Kombinasi Insulin dan Obat Antidiabetik Oral Pada Pasien Diabetes Melitus Tipe 2 di Instalasi Rawat Jalan Rumah Sakit Umum Daerah Ulin Banjarmasin. Prosiding Rakernas dan Pertemuan Ilmiah Tahunan Ikatan Apoteker Indonesia. 2016;7. e-ISSN:2541-0474.
8. McAdam-Marx C, Bellows BK, Unni S, et al., Determinants of Glycaemic Control in a Practice Setting: The Role of Weight Loss And Treatment Adherence (The DELTA Study). International Journal of Clinical Practice. 2014;68:1309-1317.
9. Abrar S, Ahmed S, Noman A, Candice widuch-mert. Landing on The MARS. British Journal of Medical Practitioners. 2012;5:a523.
10. Martínez YV, Prado-Aguilar CA, Rascón-Pacheco RA, Valdivia-Martínez JJ. Quality of Life Associated With Treatment Adherence in Patients with Type 2 Diabetes: A Cross-Sectional Study. BMC Health Serv Res. 2008;8:164.
11. Hasina R, Probosuseno P, Wiedyaningsih C. Hubungan Tingkat Kepatuhan, Kepuasan Terapi dengan Kualitas Hidup Pasien Usia Lanjut Diabetes Melitus Tipe 2. Journal of Management and Pharmacy Practice. 2014;4(4):251-256.
12. Chew B-H. Medication Adherence on Quality of Life Among Adults with Type 2 Diabetes Mellitus: An Exploratory Analysis on The EDDMQoL Study. Quality of Life Research. 2015;24(11):2723-2731.
13. Gusmai L de F, Novato T de S, Nogueira L de S. The Influence of Quality of Life in Treatment Adherence Of Diabetic Patients: A Systematic Review. Revista da Escola de Enfermagem da USP. 2015;49(5):839-846.
14. Horne R, Albert A, Boone C. Relationship Between Beliefs About Medicines, Adherence to Treatment, and Disease Activity in Patients With Rheumatoid Arthritis Under Subcutaneous Anti-TnfΑ Therapy. Patient Preference and Adherence. 2018;Volume 12:1099-1111.
15. Alfian R, Putra AMP. Uji Validitas dan Reliabilitas Kuesioner Medication Adherence Report Scale (MARS) Terhadap Pasien Diabetes Mellitus. Jurnal Ilmiah Ibnu Sina. 2017;2 (2), 176-183:8.
16. Brazier J, Roberts J, Tsuchiya A, Busschbach J. A Comparison of The EQ-5D and SF-6D Across Seven Patient Groups. Health Economics. 2004;13(9):873-884.
17. Mulhern B, Meadows K. Investigating The Minimally Important Difference of The Diabetes Health Profile (DHP-18) and The EQ-5D and SF-6D in A UK Diabetes Mellitus Population. Health. 2013;05(06):1045-1054.
18. Rwegerera GM, Moshomo T, Gaenamong M, et al., Health-Related Quality of Life and Associated Factors Among Patients with Diabetes Mellitus in Botswana. Alexandria Journal of Medicine. 2018;54(2):111-118.
19. Rodríguez-Pascual C, Rodriguez-Justo S, García-Villar E, Narro-Vidal M, Torrente-Carballido M, Paredes-Galan E. Quality of Life, Characteristics and Metabolic Control in Diabetic Geriatric Patients. Maturitas. 2011;69(4):343-347.
20. Adikusuma W, Perwitasari DA, Supadmi W. Evaluasi Kepatuhan Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Umum PKU Muhammadiyah Bantul, Yogyakarta. Media Farmasi. 2014;11(2):208-220.
21. Al-Rasheedi AAS. The Role of Educational Level in Glycemic Control among Patients with Type II Diabetes Mellitus. Int J Health Sci (Qassim). 2014;8(2):177-187.
22. Gonzalez-Zacarias AA, Mavarez-Martinez A, Arias-Morales CE, Stoicea N, Rogers B. Impact of Demographic, Socioeconomic, and Psychological Factors on Glycemic Self-Management in Adults with Type 2 Diabetes Mellitus. Frontiers in Public Health. 2016;4.
23. Al Hayek AA, Robert AA, Al Saeed A, Alzaid AA, Al Sabaan FS. Factors Associated with Health-Related Quality of Life among Saudi Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Survey. Diabetes Metab J. 2014;38(3):220-229.
24. Timar R, Velea PI, Timar B et al., Factors Influencing The Quality of Life Perception in Patients with Type 2 Diabetes Mellitus. Patient Preference and Adherence. 2016;Volume 10:2471-2477.
25. Mahler C, Hermann K, Horne R, et al. Assessing Reported Adherence to Pharmacological Treatment Recommendations. Translation and Evaluation of The Medication Adherence Report Scale (MARS) in Germany. Journal of Evaluation in Clinical Practice. 2010.
26. Lee CS, Tan JHM, Sankari U, Koh YLE, Tan NC. Assessing Oral Medication Adherence Among Patients With Type 2 Diabetes Mellitus Treated with Polytherapy in A Developed Asian Community: A Cross-Sectional Study. BMJ Open. 2017;7(9):e016317.
27. Soelistijo SA, Novida H. Tim Penyusun Revisi Konsensus Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia. PERKENI. 2015:93.
28. Megari K. Quality of Life in Chronic Disease Patients. Health Psychol Res. 2013;1(3).
29. Sayah FA, Qiu W, Xie F, Johnson JA. Comparative Performance of The EQ-5D-5L and SF-6D Index Scores in Adults With Type 2 Diabetes. Quality of Life Research. 2017;26(8):2057-2066.
30. Van den Berg B. SF-6D Population Norms. Health Economics. 2012;21(12):1508-1512.
31. Yordanova S, Petkova V, Petrova G et al., Comparison of Health Related Quality of Life Measurement Instruments in Diabetic Patients. Biotechnology & Biotechnological Equipment. 2014;28(4):769-774.
32. Perwitasari DA, Urbayatun S. Treatment Adherence and Quality of Life in Diabetes Mellitus Patients in Indonesia. SAGE Open. 2016;6(2):2158244016643748.
DOI: https://doi.org/10.22146/jmpf.42927
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