Kajian Adverse Drug Reactions Terkait Interaksi Obat di Bangsal Rawat Inap Rumah Sakit Akademik UGM

https://doi.org/10.22146/jmpf.60228

Fivy Kurniawati(1*), Nanang Munif Yasin(2), Amila Dina(3), Sanses Atana(4), Sarah Nabila Hakim(5)

(1) Departemen Farmakologi dan Farmasi Klinis, Fakultas Farmasi, Universitas Gadjah Mada
(2) Departemen Farmakologi dan Farmasi Klinis, Fakultas Farmasi, Universitas Gadjah Mada
(3) Program Sarjana Program Studi Farmasi, Fakultas Farmasi Universitas Gadjah Mada
(4) Program Sarjana Program Studi Farmasi, Fakultas Farmasi Universitas Gadjah Mada
(5) Program Sarjana Program Studi Farmasi, Fakultas Farmasi Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Adverse Drug Reactions (ADRs) is one of the causes of patient’s prolonged length of stay in the hospital and drug interactions can be included as one of the causes of the cause of ADRs. ADR related to drug interactions is a clinical problem that requires proper prevention. This study aimed to identify potential drug interactions also identify adverse drug reactions (ADRs) related to drug interactions in hospitalized patients at Universitas Gadjah Mada Teaching Hospital. This cross-sectional study used retrospective data collection through patient’s medical records from January to June 2018. Patients included in this study were all patients who received therapy more than two kind of drugs simultaneously treated in hospital wards of Universitas Gadjah Mada Teaching Hospital, Yogyakarta, Indonesia. The data collected were then analyzed descriptively. Drug interactions were analyzed using Drug Interaction Facts 2012 and Stockley. ADRs were analyzed by monitoring documented effects of patients with potential drug interaction. There were 115 of 362 patients (31.8%) with potential drug interactions. The total numbers of potential interactions that occur were 182 interactions. The most potential type of interaction was the interaction with moderate severity, with 115 interactions (63.2%). The majority of drug interactions occur through unknown mechanisms (54.4%). Actual ADR occurs in 3.3% patients who were 2 pediatric patients and 4 geriatric patients. This study can be a reference for drug interactions and ADRs as well as guide for pharmacist and healthcare in providing the right medication.


Keywords


ADRs; drug interactions; Teaching Hospital Universitas Gadjah Mada; pharmaceutical care; clinical practice

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References

  1. BPOM. Pedoman Monitoring Efek Samping Obat (MESO) Bagi Tenaga Kesehatan. Badan POM RI. https://e-meso.pom.go.id/web/useruploads/files/reference/562 75c6f030ff_PEDOMAN%20MESO_NAKES.pdf. Dipublikasikan 2012. Diakses 2 Juli 2019.
  2. Sindhu MS, Kannan B. Investigating The Factors Affecting Drug-Drug Interactions. Int J Pharm Bio Sci. 2013;4(4):(P) 467 - 476.
  3. Kaufman G. Adverse Drug Reactions: Classification, Susceptibility and Reporting. Nurs. Stand. 2016;30:53–63.
  4. Namazi S, Pourhatami S, Borhani-Haghighi A, Roosta S. Incidence of Potential Drug-Drug Interaction and Related Factors in Hospitalized Neurological Patients in two Iranian Teaching Hospitals. Iran J Med Sci. 2014;39(6):515–521.
  5. Bucsa C, Farca A, Cazacu I, et al. How Many Potential Drug – Drug Interactions Cause Adverse Drug Reactions in Hospitalized Patients?. European Journal of Internal Medicine. 2013;24:27–33.
  6. Magro L, Moretti U, Leone R. Epidemiology and Characteristics of Adverse Drug Reactions caused by Drug-Drug Interactions. Expert Opinion Drug Saf. 2012; 11:83–94.
  7. Shibbiru T, Tadesse F. Adverse Drug Reactions : An Overview. J Med Physiol Biophys. 2016;(23):(P) 7–14.
  8. Dai D, Feinstein JA, Morrison W, Zuppa F, Feudtner C. Epidemiology of Polypharmacy and Potential Drug-Drug Interactions among Pediatric Patients in Intensive Care Units of U.S. Pediatr Crit Care Med. 2017;17(5):pp. e218–e228.
  9. Percha B, Altman RB. Informatics Confronts Drug–Drug Interactions. Trends in Pharmacological Sciences. 2013;34(3):178-184.
  10. Juarez-Cedillo T, Martinez-Hernandez C, Hernandez-Constantino A, et al. Clinical Weighting of Drug-Drug Interactions in Hospitalized Elderly. Basic Clininical Pharmacol Toxicol. 2016;(118):(P) 298–305.
  11. Furdiyanti NH, Luhurningtyas FP, Sari R, et al. Evaluasi Dosis dan Interaksi Obat Antidiabetika Oral pada Pasien Diabetes Mellitus Tipe II. Jurnal Manajemen dan Pelayanan Farmasi. 2017;7(4):(P) 191–196.
  12. Feinstein J, Dai D, Zhong W, Freedman J, Feudtner, C. Potential Drug-Drug Interactions in Infant, Child, and Adolescent Patients in Children’s Hospitals. PEDIATRICS. 2014;135(1):e99-e108.
  13. Faizah AK. Kajian Interaksi Obat pada Pasien Pneumonia di RS Pendidikan Surabaya. Jurnal Scientia. 2018;8(1):86–91.
  14. Hendera, Rahayu S. Interaksi Antar Obat pada Peresepan Pasien Rawat Inap Pediatrik Rumah Sakit X dengan Menggunakan Aplikasi Medscape. JPCS. 2018;1(2): 75-80.
  15. Morales-RõÂos O, Jasso-GutieÂrrez L, Reyes-LoÂpez A, et al. Potential Drug-Drug Interactions and Their Risk Factors in Pediatric Patients Admitted to The Emergency Department of a Tertiary Care Hospital in Mexico. PLoS ONE. 2018;13(1):e0190882.
  16. Cho CM, Lee YM. The Relationship Between Cardiovascular Disease Risk Factors and Gender. Health. 2012; 4(6):(P)309-315.
  17. Faizah AK. Kajian Interaksi Obat pada Pasien Pneumonia di RS Pendidikan Surabaya. Jurnal Scientia. 2018;8(1):86–91.
  18. Hassanzad M, Arenas-lopez S, Baniasadi S. Potential Drug – Drug Interactions Among Critically Ill Pediatric Patients in a Tertiary. The Journal of Clinical Pharmacology. 2017;00(0):pp.1–7.
  19. Saiyed MM, Lalwani T, Rana D. Off-Label Medicine Use in Pediatric Inpatients: A Prospective Observational Study at a Tertiary Care Hospital in India. International Journal of Pediatrics. 2014;_:p. 6 pages.
  20. Ismail M, Iqbal Z, Khan MI, et al. Frequency, Levels and Predictors of Potential Drug-Drug Interactions in a Pediatrics Ward of a Teaching Hospital in Pakistan. Trop J Pharm Res. 2013;12(3):401–406.
  21. Nabovati E, Vakili-arki H, Taherzadeh Z, et al. Drug-Drug Interactions in Inpatient and Outpatient Settings in Iran : a Systematic Review of the Literature. DARU Journal of Pharmaceutical Sciences. 2014;22:52.
  22. Murtaza G, Khan MY, Azhar S, et al. Assessment of Potential Drug-Drug Interactions and Its Associated Factors in The Hospitalized Cardiac Patients. Saudi pharmaceutical journal: the official publication of the Saudi Pharmaceutical Society. 2016;24(2):220–225.
  23. George AS, Ramesh M, Sebastian J. Adverse Drug Reactions in Elderly Hospitalized Patients: A Prospective Analysis. Int J Pharm Sci Res. 2018;9(5):(P) 13-20.
  24. Rashed A, Mohammed WA, Marwan AE, Fahad AA, Alqarni M, Maimsh O, Aljefri HM. Medication Safety Practice in Pediatric Ward. The Egyptian Journal of Hospital Medicine. 2018;71(5):pp. 3236–3240.
  25. Cristina M, Rodrigues S, Oliveira C. Drug-Drug Interactions and Adverse Drug Reactions in Polypharmacy among Older Adults : An Integrative Review. Rev Latino-Am Enferm. 2016;(24):(P) 1-17.
  26. Reis AM, Cassiani SH. Prevalence of Potential Drug Interactions in Patients in an Intensive Care Unit of a University Hospital in Brazil. Clinics (Sao Paulo). 2011;66(1):9-15.
  27. Masukawa MY, Veríssimo GB, Vianello MH, et al. Drug Interactions in Children with Respiratory Diseases in the Pediatric Unit of a Teaching Hospital in Brazil. Revista Cubana de Pediatría. 2016;88(2):166–181.
  28. Yanti E, Kristin E, Yasmina A. Potential Drug Interactions in Hypertensive Patients in Liwa District Hospital, Lampung Barat, Indonesia. International Journal of Pharmacy and Pharmaceutical Sciences. 2017;9(6):134-138.
  29. Guerzoni S, Lanfranco P. Alberto PL, et al. Drug-Drug Interactions in The Treatment for Alcohol Use Disorders. Pharmacol. Res. 2018;133:65-76.
  30. Teixeira JJ, Crozatti MT, dos Santos CA, et al. Potential Drug-Drug Interactions in Prescriptions to Patients Over 45 years of Age in Primary Care, Southern Brazil. PloS one. 2012;7(10):e47062.
  31. Sjahadat AG, Muthmainah SS. Analisis Interaksi Obat Pasien Rawat Inap Anak di Rumah Sakit di Palu. Jurnal Farmasi Klinik Indonesia. 2013;2(4):pp. 1–6.
  32. Tatro DS. Drug Interaction Facts. California: Wolters Kluwer Health Inc, 2012.
  33. Kibrom S, Tilahun Z, Huluka SA. Potential Drug-Drug Interactions among Adult Patients Admitted to Medical Wards at a Tertiary Teaching Hospital in Ethiopia. Journal of Drug Delivery and Therapeutics. 2018;8(5–s):348–354.
  34. Maheshwari P, Praveen D, Ravichandiran V. Adverse Drug Reactions of NSAIDs in General Care Hospital. Asian Journal of Pharmaceutical and Clinical Research. 2014;7(3):69-71.
  35. Greener M. Understanding Adverse Drug Reactions: An Overview. Nurse Prescribing. 2014;12(4):189–195.
  36. Baxter K. Stockley’s Drug Interactions : A Source Book of Interactions, Their Mechanism, Clinical Importance and Management. London: Pharmaceutical Press, 2010.
  37. May M, Schindler C. Clinically and Pharmacologically Relevant Interactions of Antidiabetic Drugs. Ther. Adr. Endocrinol.Metab. 2016;7(2):69-83.
  38. Gunaratne K, Austin E, Wu PE. Uninternational Sulfonylurea Toxicity due to a Drug-Drug Interaction : A Case Report. BMC Res. Notes. 2018;11(331):1-3.
  39. Oh SW, Han SY. Loop Diuretics in Clinical Practice. The Korean Society of Electrolyte Metabolism. 2015;13(1):17-21.



DOI: https://doi.org/10.22146/jmpf.60228

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