The Relationship of Drug Therapy Problems and Outcome Therapy in Tuberculosis Patients in Surabaya Health Center

https://doi.org/10.22146/jmpf.98345

I Nyoman Wijaya(1*), Luthfia Andini Nathganeila(2), Yuni Priyandani(3)

(1) Pharmacy Practice Department, Faculty of Pharmacy, Airlangga University, Surabaya, East Java
(2) Pharmacy Practice Department, Faculty of Pharmacy, Airlangga University, Surabaya, East Java
(3) Pharmacy Practice Department, Faculty of Pharmacy, Airlangga University, Surabaya, East Java
(*) Corresponding Author

Abstract


Background: Tuberculosis (TB) is a highly contagious disease and is difficult to eradicate in Indonesia. Indonesia ranks second in the number of TB sufferers in the world. Generally, TB patients use more than two types of drug therapy it can affect the drug therapy problems that arise and can affect the success of treatment.

Objectives: This study aims to see the effect of the number of drugs used by TB patients on the number of drug therapy problems (DTP) and therapy outcomes in tuberculosis patients.

Methods: This study was a cross-sectional study with purposive sampling conducted at health centers in the Surabaya area in January- June 2024. The sample inclusion criteria included pulmonary tuberculosis patients who had undergone treatment for over one month, were not less than 17, and could communicate well using a guided interview method.

Results: The results showed that the number of patients who participated in the study was 110 people. Most patients used 4 types of drugs (30.0%). Most (30.0%) had two DTPs. Spearman's relationship test between the number of drugs and the number of DTPs with a p-value = 0.000 and a correlation coefficient of 0.472. Spearman's relationship test between the number of DTP and the outcome therapy with a p-value = 0.430 and a correlation coefficient of -0.076.

Conclusion: From this study, it can be concluded that there is a significant relationship between the number of drugs and the number of DTPs in TB patients and there is no relationship between RTP and therapeutic outcomes in TB patients.


Keywords


DTPs; Health centers; Outcome therapy; Tuberculosis

Full Text:

PDF


References

  1. WHO (2022). Global Tuberculosis Report. Geneva, Switzerland.
  2. Ministry of Health, Republic of Indonesia. (2022). Stop Tuberculosis. Jakarta: Republic of Indonesia Ministry of Health.
  3. Surabaya City Health Service. (2020). Health Profile 2020. Surabaya: Surabaya City Health Service.
  4. Ministry of Health, Republic of Indonesia. (2019). National Guidelines for Tuberculosis Management Medical Services. Jakarta: Indonesian Ministry of Health.
  5. Priyandani, Y., A.A.F., Agung, N.A.F., Ramadhani, N., Nita, Y., Mufarrihah, Dian, S.C., Utami, W., & Athijah, U. (2014). Profile of Drug Therapy Problems in Tuberculosis Patients in Several Community Health Centers in Surabaya. Journal of Community Pharmacy, 1(2), 30–35.
  6. Cipolle, R. J., Strand, L. M., & Morley, P. C. (2012). Chapter 1 . Medication Management Services Medication Management Services Emerge: A Definition. Pharmaceutical Care Practice: The Patient-Centered Approach to Medication Management Services, 3e, Part D, 1–30.
  7. Fitriyani, F. (2016). Identification of Drug Related Problems (DRPs) Category of Drug-Drug Interactions in Hypertension Patients at RSUD Haji Makassar Prov. South Sulawesi, 2017.
  8. Sunarmi and Kuriawaty. 2022. Relationship between characteristics of pulmonary TB patients and the incidence of tuberculosis. Aisyiyah Medika Journal, Vol.7 No.2
  9. Ministry of Health, Republic of Indonesia. (2020). National Guidelines for Tuberculosis Management Medical Services. Jakarta: Republic of Indonesia Ministry of Health.
  10. Andayani S, Astuti Y. 2017. Prediction of the incidence of pulmonary tuberculosis based on age in Ponorogo Regency 2016-2020. Indonesian Journal Health Science. Vol. 1, No. 2. Pg. 29.
  11. Mientarini, E.I., Sudarmanto, Y., and Hasan, M., 2018. The Relationship between Knowledge and Attitudes towards Medication Compliance in Advanced Phase Pulmonary Tuberculosis Patients in Umbulsari District, Jember. Ikesma, Vol. 14 No. 1, p. 11-18. doi: 10.19184/ikesma.v14i1.10401.
  12. Absor, S., Nurida, A., Levani, Y., & Nerly, W. S. (2020). The relationship between education level and compliance with treatment for pulmonary TB sufferers in the Lamongan Regency area in January 2016-December 2018. Medica Arteriana (Med-Art).2(2):80-87.
  13. Mar'iyah, K., & Zulkarnain. (2021). Pathophysiology of tuberculosis infection. Proceedings of the National Seminar on Biology, https://doi.org/10.24252/psb.v7i1.23169.
  14. Fortuna, T. A., Rachmawati, H., Hasmono, D., & Karuniawati, H. (2022). Study of the Use of Anti-Tuberculosis Drugs (OAT) in Advanced Stages in New BTA Positive Patients. Pharmacon: Indonesian Pharmacy Journal, 19(1), 62-71.
  15. Khotimah, K., & Sutrisna, E. M. (2023). Identification of DRPs (Drug Related Problems) for intensive stage tuberculosis treatment in geriatric patients at RSUP Surakarta. Identification of drug-related problems (DRPs) in the intensive phases of tuberculosis treatment in geriatric patients at RSUP Surakarta. Medical Sins. Pharmaceutical scientific journal, 8(3), 945-954.
  16. Cui, A., Fan, H., Zhang, Y., Zhang, Y., Niu, D., Liu, S., Liu, Q., Ma, W., Shen, Z., Shen, L ., Liu, Y., Zhang, H., Xue, Y., Cui, Y., Wang, Q., Xiao, X., Fang, F., Yang, J., Cui, Q., & Chang, Y. (2019). Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia. The Journal of clinical investigation, 129(6), 2266–2278. https://doi.org/10.1172/JCI66062.
  17. Ministry of Health, Republic of Indonesia. (2016). Regulation of the Minister of Health of the Republic of Indonesia Number 67 of 2016 concerning Tuberculosis Management. Jakarta: Indonesian Ministry of Health.
  18. Azzahra, Sevilla Elza., Iswandi and Sumaryana. 2022. Study of Potential Drug Interactions in Pulmonary TB Patients at Dr. Hospital. Gondo Suwarno, Semarang Regency, 2021. Indo Pharm Journal, Vol2 No.2.
  19. Baxter K. Stockley's Drug Interactions. Eighth edition. London: Pharmaceutical Press; 2008.
  20. Tajudin, T., Ulfah, U., & Permana, D. A. S. (2022). Identification of Adverse Drug Reactions to the Use of Anti-Tuberculosis Pulmonary Drugs in the UPTD of the Kroya I Community Health Center for the Period January 2019–December 2020. In Proceedings of the National Seminar on Dissemination of Research Results of the Undergraduate Pharmacy Study Program (Vol. 2, No. 1).
  21. Charles A. Peloquin. Pharmacotherapy: A Pathophysiologic Approach. 7th ed. New York: McGrew-Hill Companies, Inc 2012
  22. Fathiyah Isbaniah, Erlina Burhan, Bintang YM Sinaga, Dewi Behtri, Yanifitri, Diah Handayani, Harsini, Heidy Agustin, I Nengah Artika, Jatu Aphridasari, Rohani Lasmaria, Russilawati, Soedarsono, Yani Jane R. Sugiri. (2021). TUBERKULOSIS Guidelines for Diagnosis and Management in Indonesia. Indonesian Lung Doctors Association. Jakarta.
  23. Ayu Fortuna, Fita Rahmawati, Nanang Munif Yasin (2021). Association between Drug Related Problems (DRPs) and Outcomes Therapy in Tuberculosis Patients with Diabetes Mellitus. JMPF. Vol 11(2). DOI : 10.22146/jmpf.62602.



DOI: https://doi.org/10.22146/jmpf.98345

Article Metrics

Abstract views : 1215 | views : 488

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Jurnal Manajemen dan Pelayanan Farmasi
Faculty of Pharmacy
Universitas Gadjah Mada
Creative Commons License
View My Stats