Recombinant Human Erythropoietin: Manfaat dalam Bidang Kedokteran
Yanuartono Yanuartono(1*), Hary Purnamaningsih(2), Alfarisa Nururrozi(3), Soedarmanto Indarjulianto(4), Slamet Raharjo(5)
(1) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(2) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(3) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(4) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(5) Fakultas Kedokteran Hewan Universitas Gadjah Mada
(*) Corresponding Author
Abstract
Recombinant human erythropoietin (rhEPO) is one of the biotechnology-based drugs that are needed by the human medicine and has also been used in the veterinary medicine. Currently RhEPO has been widely used in the world of human medicine for the treatment of anaemia caused by renal failure, cancer, chronic inflammation and AIDS. In veterinary medicine, although there is still not much data on its achievements, rhEPO has also been used for cases of chronic renal failure in dogs and cats. However, since rhEPO is not identical to feline EPO and canine EPO, some patients eventually produce antibodies against the drug. The antibodies not only prevent EPO therapy from being effective, but also may lead to severe and life-threatening anemia. This paper provides a review of the use of RhEPO, rfEPO and rcEPO in veterinary medicine, especially for the purpose of non-regenerative anemia therapy in cases of chronic renal failure in dogs and cats.
Keywords
Full Text:
PDFReferences
Andrews, D.A., Pyrah, I.T.G., Boren, B.M., Tannehill-Gregg, S.H., And Ruth M. Lightfoot-Dunn, R.M. (2014). High Recombinant Human Erythropoietin: Manfaat dalam Bidang Kedokteran Hematocrit Resulting from Administration of Erythropoiesis-stimulating Agents Is Not Fully Predictive of Mortality or Toxicities in Preclinical Species. Toxicologic Pathology, 4 2 : 5 1 0 - 5 2 3 . D O I : 10.1177/0192623313486317
Barth, T., Oliveira, P.R., Felipe, B., D'avila, F.B. And Dalmora. S.L. (2008). Validation of the NormocythemicMice Bioassay for the Potency Evaluation of Recombinant Human Erythropoietin inmPharmaceutical Formulations. Journal Of Aoac International.91 (2): 85-291. http://dx.doi.org/10.1590/S0100879X2003001100014
Beall, C.J., Phipps, A.J., Mathes, L.E., Stromberg, P., And Johnson, P.R. (2000) Transfer of the feline erythropoietin gene to cats using a recombinant adeno-associated virus vector. Gene Therapy 7 (6): 534–539. DOI: 10.1038/sj.gt.3301126
Bernado, P., Rahardjo, And Rahajoe, P.S. (2016). Pengaruh recombinant human Erythropoietin terhadap jumlah osteoblas, osteoklas dan kadar hemoglobin pada penyembuhan fraktur tulang mandibula. Studi eksperimental pada fraktur mandibula tikus Sprague-Dawley. J Ked Gi. 7(2): 131137
Bernaudin, M., Marti, H.H., Roussel, S., Divoux, D., Nouvelot, A., MacKenzie, E.T. And Petit, E. (1999). A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J Cereb Blood Flow Metab. 19 (6):643–651. DOI:10.1097/00004647-199906000-00007
Boran, M., Dalva, I., Yazicioglu, A., Akbay, E. And Cetin, S. (1993). Correction of anaemia in haemodialysis patients with recombinant human erythropoietin. Int Urol Nephrol 25 (2): 197–203. PMID:8365853
Bron, D., Meuleman, N. And Mascaux, C. (2001). Biological basis of anemia. Semin Oncol 28(2 Suppl 8):1-6. PMID:11395845 Browne, J.K., Cohen, A.M., Egrie, J.C., Lai, P.H., Lin, F.K., Strickland, T., Watson, E. And Stebbing, N. (1986). Erythropoietin: gene cloning, protein structure, and biological properties. Cold Spring Harb Symp Quant B i o l . 5 1 ( P t 1 ) : 6 9 3 – 7 0 2 .
doi:10.1101/SQB.1986.051.01.082
Bugelski, P. J., Nesspor, T., Volk, A., O'Brien, J., Makropoulos, D., Shamberger, K., Fisher, P. W., James, I., Graden, D., And Capocasale, R. J. (2008). Pharmacodynamics of recombinant human erythropoietin in murine bone marrow. Pharm Res 25(2): 369–78. DOI:10.1007/s11095-007-9372-7
Chalhoub, S., Langston, C.E. And Eatroff, A. (2011). Anemia of renal disease. J Fel Med Surg. 1 3 ( 9 ) : 6 2 9 - 6 4 0 . d o i : 10.1016/j.jfms.2011.07.016.
Chalhoub, S., Langston, C.E. and Farrelly, J. (2012). The Use of Darbepoetin to Stimulate Erythropoiesis in Anemia of Chronic Kidney Disease in Cats: 25 Cases. J Vet Intern Med 26 (2):363–369. doi: 10.1111/j.19391676.2011.00864.x
Chew, D.J., DiBartola, S.P., And Schenck, P. (2011). editors. Chronic renal failure. In Canine and Feline Nephrology and Urology. St. Louis, Missouri: Elsevier Saunders.; 145-96. Choi, D., Kim, M. And Park, J. (1996). Erythropoietin: physico- and biochemical analysis. Journal of Chromatography. 687(1): 189199.https://doi.org/10.1016/S03784347(96)00308-8
Coleman, T. And Brines. M. (2004) Science review: Recombinant human erythropoietin in critical illness: a role beyond anemia? Critical Care 8 (5): 337-341 DOI 10.1186/cc2897)
Conley, A.J., Mohib, K., Jevnikar, A.M. And Brandle. J.E. (2009). Plant recombinant erythropoietin attenuates inflammatory kidney cell injury. Plant Biotechnology Journal 7(2): 183–199. doi: 10.1111/j.14677652.2008.00389.x
Cowgill, L D., James, K. M., Levy, J. K, Browne, J.K., Miller, A., Lobingier, R.T., And Egrie, J.C. (1998). Use of recombinant human erythropoietin for management of anemia in dogs and cats with renal failure. Journal of the American Veterinary Medical Association 212(4):521-528. PMID:9491159
Cowgill, L.D. (1991). Erythropoietin: Its use in the treatment of chronic renal failure in dogs and cats. Proc Annu Waltham/OSU Symp Treat Small Anim Dis.15:65–71.
Delorme, E., Lorenzini, T., Giffin, J., Martin, F., Jacobsen, F., Boone, T. And Elliott, S. (1992). Role of glycosylation on the secretion and biological activity of erythropoietin. Biochemistry. 31(41): 9871–9876. DOI: 10.1021/bi00156a003
Eder, H., Roblenbroich, B. And Failing, K. (1989). A dose-dependent effect of recombinant erythropoietin on the reticulocyte population of rats. Blut. 59(2): 184-187. PMID:2475191 Egrie, J. (1990). The cloning and production of recombinant human erythropoietin. Pharmacotherapy 10(Pt2):3S–8S. PMID:2345709
Egrie, J.C., Strickland, T.W., Lane, J., Aoki, K., Cohen, A.M., Smalling, R., Trail, G., Lin, F.K., Browne, J.K. And Hines, D.K. (1986). Characterization and biological effects of recombinant human erythropoietin. Immunobiology. 172(3-5):213-24. DOI:10.1016/S0171-2985(86)80101-2
Egrie, J. C. And Browne, J. K. (2001). Development and characterization of novel erythropoiesis stimulating protein (NESP). Br J Cancer. 84 ( S u p p l 1 ) : 3 – 1 0 . d o i : 10.1054/bjoc.2001.1746
Elliott, S., Pham, E. And Macdougall, I.C. (2008). Erythropoietins: A common mechanism of action. Exp Hematol. 36(12):1573–84. doi: 10.1016/j.exphem.2008.08.003 Eschbach, J.W. (1989). The anemia of chronic renal failure: Pathophysiology and the effects of recombinant erythropoietin. Kidney Int. 3 5 ( 1 ) : 1 3 4 – 1 4 8 .
D O I : https://doi.org/10.1038/ki.1989.18
Eschbach, J.W., Egrie, J.C., Downing, M.R., Browne, J.K. And Adamson, J.W. (1987). Correction of the anaemia of end-stage renal disease with recombinant human erythropoietin: results of a combined phase I and II clinical trial. N Engl J Med 316 (2) :73–78. DOI: 10.1056/NEJM198701083160203
Fiocchi, E.H., Cowgill, L.D., Brown, D.C., Markovich, J.E., Tucker, S., Labato, M.A., And Callan, M.B. (2017). The Use of Darbepoetin to Stimulate Erythropoiesis in the Treatment of Anemia of Chronic Kidney Disease in Dogs. J Vet Intern Med. 31(2):476–485 DOI: 10.1111/jvim.14681
Fuadi, I. And Bisri, T. (2015). Efek Proteksi Otak Erythropoietin. JNI 4 (2): 149–56 Gao, G., Lebherz, C., Weiner, D.J., Grant, R., Calcedo, R., McCullough, B., Bagg, A., Zhang, Y. And Wilson, J.M. (2004). Erythropoietin gene therapy leads to autoimmune anemia in macaques. Blood. 103 (9): 3300-3302. doi:10.1182/blood-2003-11-3852
Garrido, P., Reis, F., Costa, E., Almeida, A., Parada, B.E., Teixeira-Lemos, E., Santos, P., Alves, R., Sereno, J., Pinto, R., Tavares, C.A., Figueiredo, A., Rocha-Pereira, P., Belo, L., Santos-Silva, A. And Teixeira, F. (2010). Effect of Recombinant Human Erythropoietin in a Rat Model of Moderate Chronic Renal Failure – Focus on Inflammation, Oxidative Stress and Function/Renoprotection. The Open Drug Discovery 22(2) : 25-32. DOI:
2174/1877381801002020025
Giger U. (1992). Erythropoietin and its clinical use. Compend Contin Educ Pract Vet 14 :25–34. Giger, U. (1991). Serum erythropoietin concentrations in polycythemic and anemic dogs. Proc 9th ACVIM Forum:143–145. Goodnough, L.T., Skikne, B. And Brugnara, C. (2000). Erythropoietin, iron, and erythropoiesis. Blood 96 (3): 823-833. PMID:10910892
Goto, M., Akai, K., Murakami, A., Hashimoto, C., Tsuda, E., Ueda, M., Kawanishi, G., Takahashi, N., Ishimoto, A., Chiba, H. And Sasaki, R. (1988). Production of recombinant human erythropoietin in mammalian cells: host-cell dependency of the biological activity of the cloned glycoprotein. Nature Biotechnology. 6(1): 67–71. DOI: 10.1038/nbt0188-67
Hamilton, S.R., Davidson, R.C., Sethuraman, N., Nett, J.H., Jiang, Y., Rios, S., Bobrowicz, P., Stadheim, T.A., Li, H., Choi, B.K., Hopkins, D., Wischnewski, H., Roser, J., Mitchell, T., Strawbridge, R.R., Hoopes, J., Wildt, S. Gerngross, T.U. (2006). Humanization of yeast to produce complex terminally sialylated glycoproteins. Science, 313: 1441–1443. DOI:10.1126/science.1130256
Henry, P. (1994). Human recombinant erythropoietin used to treat a cat with anemia caused by chronic renal failure. Can Vet J. 35(6) :375. PMID: 8069840
Hoeksema, F. (2011). Selection markers and expression enhancing elements: Novel strategies to create mammalian production cell lines. Faculty of Science. University of Amsterdam. Thesis Dissertation. Available at: http://dare.uva.nl/document/ 482571
Huang, L.S. (1984). Cloning and expression of human erythropoietin cDNA in Escherichia coli. Proc. Natl. Acad. Sci. USA, 81(9): 27082712. PMID: 6371819 Ifeanyi, O.E. And Uzoma, O.G. (2016). Erythropoietin and Kidney Diseases: A Review. J. Biol. Chem. Research. 33 (2): 760-792
Ifudu, N., Matthew, J.J., Mayers, J.D., Macey, L.J., Brezsnyak, W., Reydel, C., McClendon, E., Surgrue, T., Sreepada Rao, T.K. And Friedman, E.A. (1997). Severity of AIDS and the response to EPO in uremia. American Journal of Kidney Diseases 30 (1): 28-35. DOI: https://doi.org/10.1016/S02726386(97)90561-8 Imai, N.,
Kawamura, A., Higuci, M., Oh-Eda, M., Orita, T., Kawagchi, T., And Ochi, N. (1990). Physicochemical and Biological Comparison of Recombinant Human Erythropoietin with Human Urinary Erythropoietin1. Journal of Biochemistry 1 0 7 ( 3 ) : 3 5 2 - 3 5 9 DOI::10.1093/oxfordjournals.jbchem.a1230 50
Inoue, N., Takeuchi, M., Ohashi, H. And Suzuki, T. (1995) The production of recombinant human erythropoietin. Biotechnol Annu Rev. 1 9 9 5 ( 1 ) : 2 9 7 - 3 1 3 . https://doi.org/10.1016/S13872656(08)70055-3
Jacobs, K., Shoemaker, C., Rudersdorf, R., Neill, S.D., Kaufmann, R.J., Mufson, A., Seehra, J., Jones, S.S., Hewick, R., And Fritsch, E.F. (1985). Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature. 313(6005): 806-810. PMID:3838366
Jelkmann, W. (1992). Erythropoietin: structure, control of production and function. Physiol Rev. 7 2 ( 2 ) : 4 4 9 – 8 9 . D O I : 10.1152/physrev.1992.72.2.449
Jelkmann, W. (2000). Use of recombinant human erythropoietin as an anti-anemic and performance enhancing drug. Curr Pharmaceut Biotechnol. 1(1):11–31. DOI: https://doi.org/10.2174/1389201003379068
Jelkmann, W. (2008). Developments in the therapeutic use of erythropoiesis stimulating agents. British Journal of Haematology. 141(3): 287–297 doi:10.1111/j.13652141.2007.06948.x Jelkmann, W. (2013). Physiology and Pharmacology of Erythropoietin. Transfus Med Hemother. 40(5):302–309 DOI: 10.1159/000356193
Kim, Y.K., Shin, H.S., Tomiya, N., Lee, Y.C., Betenbaugh, M.J. And Cha, H.J. (2005). Production and N-glycan analysis of secreted human erythropoietin glycoprotein in stably transfected Drosophila S2 cells. Biotechnol. Bioeng. 92(4): 452–461. DOI: 10.1002/bit.20605
King, L.G., Giger, U., Diserens, D., And Nagode, L.A. (1992). Anemia of chronic renal failure in dogs. J Vet Intern Med. 6 (5): 264–270. PMID: 1432900
Koury, S.T., Koury, M.J., Bondurant, M.C., Caro, J. And Graber, S.E. (1989). Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: Correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration. Blood 74(2): 645-51. PMID: 2752138
Koury, S.T., Bondurant, M.C., And Koury, M.J. (1988). Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization.Blood. 71:524–527. PMID:3337914 Kumar, J., Reccia, I., Kusano, T. And Agrawal, S. (2017). A Systematic Review on the Erythropoietin Receptors Expression in Various Cancers and Importance of Recombinant Erythropoietin in Chemotherapy Induced Anaemia. Hematol Transfus Int J. 4(1):1-6. DOI: 10.15406/htij.2017.04.00072
Langston, C., Cook, A.. Eatroff, A., Mitelberg, E. And Chalhoub S. (2017). Blood Transfusions in Dogs and Cats Receiving Hemodialysis: 230 Cases (June 1997–September 2012). J Vet Intern Med. 31(2):402–409. DOI:10.1111/jvim.14658
Langston, C.E., Reine, N.J., And Kittrell, D. (2003). The use of erythropoietin. Vet Clin North Am Small Anim Pract. 33(6):1245-1260. PMID:14664197
Law, M.L., Cai, G.Y., Lin, F.K., Wei, Q., Huang, S.Z., Hartz, J.H., Morse, H., Lin, C. H., Jones, C. And Kao, F. T. (1986). Chromosomal assignment of the human erythropoietin gene and its DNA polymorphism. Proc Natl Acad Sci U S A. 83 (18):6920–6924. DOI: 10.1073/pnas.83.18.6920
Loughnan, A., Galil Rahman Ali, G.R. And Abeygunasekara, S.C. (2011). Comparison of the Therapeutic Efficacy of Epoetin Beta and Epoetin Alfa in Maintenance Phase Hemodialysis Patients, Renal Failure. 33 ( 3 ) : 3 7 3 - 3 7 5 , D O I : 10.3109/0886022X.2011.559675
MacLeod, J.N. (2001). Clinical Trials of Recombinant F e l i n e E P O U n d e r w a y . https://www.cabi.org/agbiotechnet/news/41 7 MacLeod, J.N., Tetreault, J.W., Lorschy, K.A., And Gu, D.N. (1998). Expression and bioactivity of recombinant canine erythropoietin. Am J Vet Res 59 (9):1144–1148. PMID: 9736393
Mikiciuk, M.G., Polzin, D.J., And Osborne, C.A. (1990). The use of erythropoietin in chronic renal failure. Adv Small Animal Med Surg. 3:1–3.
Miyazaki, Y., Kuryama, K., Higuchi, H., Sohda, H., Imai, N., Saito, M., Kondo, T. And Tomonaga, M, (1997). Establishment and characterization of a new erythropoietindependent acute myeloid leukaemia cell line, AS-E2. Leukemia, 11(11): 1941-1949. DOI:
1038/sj.leu.2400838
Oishi, A., Hamada, S., Sakamoto,H., And Shimizu, R. (1995). Preventive effects of recombinant human erythropoietin administration on anemia associated with repeated hemodialysis in nephrectomized dogs. J Vet Med Sci 57(5): 989–90. DOI: 10.1292/jvms.57.989
Peeters, H.R.M., Jongen-Lavrencic, M., Bakker, C.H., Vreugdenhil, G., Breedveld, F.C. And Swaak, A. J. G. (1999). Recombinant human erythropoietin improves health-related quality of lifein patients with rheumatoid arthritis and anaemia of chronic disease; utility measures correlate strongly with disease activity measures. Rheumatol Int. 1 8 ( 5 - 6 ) : 2 0 1 – 2 0 . https://doi.org/10.1007/s002960050085
Qiu, H., Belanger, A., Yoon, H.P. And Bunn, H.F. (1998). Homodimerization restores biological activity to an inactive erythropoietin mutant. Journal of Biological Chemistry. 273(18): 11173-11176. doi: 10.1074/jbc.273.18.11173
Ramakrishnan, R., Cheung, W.K., Farrell, F., Joffee, L., And Jusko, W.J. (2003). Pharmacokinetic and Pharmacodynamic Modeling of Recombinant Human Erythropoietin after Intravenous and Subcutaneous Dose Administration in Cynomolgus Monkeys Journal Of Pharmacology And Experimental Therapeutics. 306 (1): 324-331.DOI: 10.1124/jpet.102.047191.
Randolph ,J.F., Stokol, T., Scarlett, J.M. And MacLeod ,J.N. (1999). Comparison of biological activity and safety of recombinant canine erythropoietin with that of recombinant human erythropoietin in clinically normal dogs. Am J Vet Res. 60(5):636–642. PMID:10328437
Randolph, J.F., Scarlett, J., Stokol, T. And MacLeod., J.N. (2004). Clinical Efficacy and Safety of Recombinant Canine Erythropoietin in Dogs with Anemia of Chronic Renal Failure and Dogs with Recombinant Human Erythropoietin‐Induced Red Cell Aplasia. J Vet Intern Med. 18(1):81–91. https://doi.org/10.1111/j.19391676.2004.tb00139.x
Rodrigue, M.E., Brochu, I., orléans-Juste, P.D., Larivièrea, R., And Lebel, M. (2008). Effect of Erythropoietin on Blood Pressure and on the Vascular Endothelial ET-1/ETB Receptor System. Am J Hypertens. 21(6):639-643. doi:10.1038/ajh.2008.37
Sadamoto, Y., Igase, K., Sakanaka, M., Sato, K., Otsuka, H., Sakaki, S., Masuda, S. And Sasaki, R. (1998). Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. Biochem Biophys Res Commun 253(1):26–32. DOI: 10.1006/bbrc.1998.9748
Sanderson, S. (2005). Use of Erythropoietin and Calcitriol for Chronic Renal Failure in Dogs thand Cats. 30 World Congress of The World Small Animal Veterinary association. May 11-14, 2005. Mexico City, Mexico
Sandhi, A. (2015). The Effect Of Erythropoietin Administration In Experimental Burns Wound Healing: An Animal Study. Thesis. Faculty Of Medicine University Of Indonesia Plastic Reconstructive And Aesthetic Surgery Study Program.
Shi., X., Yang., J., Zhu, H.,Ye, L., Feng, M., Li, J., Huang, H., Tao, Q., Ye, D., Sun, L.H.K., Sun, B.N.C., Sun, C.R.Y., Han, G., Liu, Y., Yao, M . , Z h o u , P. A n d J u , D . (2013).Pharmacokinetics and Pharmacodynamics of Recombinant Human EPO-Fc Fusion Protein In Vivo. PloS ONE 8(8):e72673. doi:10.1371/journal.pone.0072673
Skibeli, V., Nissen-Lie, G. And Torjesen, P. (2001). Sugar Profiling Proves that Human Serum Erythropoietin Differs From Recombinant Human Erythropoietin. Blood. 98 (13): 3 6 2 6 - 3 6 3 2 . D O I :
1182/blood.V98.13.3626
Storring, P.L., Tiplady, R.J., Gaines Das, R.E., Stenning, B.E., Lamikanra, A., Rafferty, B. And Lee, J. (1998). Epoetin alfa and beta differ in their erythropoietin isoform compositions and biological properties. Br J Haematol 100 (1): 79–89. DOI: 10.1046/j.1365-2141.1998.00521.x
Surabattula, R., Sambasiva, K. R. S. And Polavarapu, R. (2011). An optimized process for expression, scale-up and purification of recombinant erythropoietin produced in Chinese hamster ovary cell culture. Research in Biotechnology. 2(3): 58-74 Tamadon, M.R. And Beladi-Mousavi, S.S. (2013). Erythropoietin; a review on current knowledge and new concepts. J Renal Inj P re v . 2 ( 4 ) : 11 9 - 1 2 1 . D O I : 10.12861/jrip.2013.38
Toledo, J.R., Sanchez, O., Segui, R.M., Garcia, G., Montanez, M., Zamora, P.A., Rodriguez, M.P. And Cremata, J.A. (2006). High expression level of recombinant human erythropoietin in the milk of non-transgenic goats. J. Biotechnol. 123(2): 225–235.DOI: 10.1016/j.jbiotec.2005.10.019
Wen, D., Boissel, J.P., Tracy, T.E., Gruninger, R.H., Mulcahy, L.S., Czelusniak, J., Goodman, M., And Bunn, H.F. (1993). Erythropoietin Structure-Function Relationships: High Degree Of Sequence Homology Among Mammals. Blood. 82 (5):1507-1516. PMID: 8364201
Yin, H. And Blanchard, K.L. (2000). DNA methylation represses the expression of the human erythropoietin gene by two different mechanisms. Blood. 95(4): 111-119. PMID: 10607693
DOI: https://doi.org/10.22146/jsv.48516
Article Metrics
Abstract views : 3875 | views : 22097Refbacks
- There are currently no refbacks.
Copyright (c) 2019 Jurnal Sain Veteriner
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Jurnal Sain Veteriner Indexed by
Copyright of JSV (Jurnal Sain Veteriner) ISSN 0126-0421 (print), ISSN 2407-3733 (online).
Fakultas Kedokteran Hewan, Universitas Gadjah Mada
Jl. Fauna No.2, Karangmalang, Yogyakarta
Phone: 0274-560862
Fax: 0274-560861
Email: jsv_fkh@ugm.ac.id
HP. 0895363078367
Jurnal Sain Veteriner is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
View My Stats