Melamine, Asam Suanurat dan Melamin-Sianurat: Kaitan dengan Penyakit Saluran Perkencingan Hewan

Yanuartono Yanuartono; Alfarisa Nururrozia; Soedarmanto Indarjulianto; Hary Purnamaningsih; Slamet Rahardjo

doi:10.22146/jsv.48601

Melamine, Asam Suanurat dan Melamin-Sianurat: Kaitan dengan Penyakit Saluran Perkencingan Hewan

https://doi.org/10.22146/jsv.48601

Yanuartono Yanuartono^(1*), Alfarisa Nururrozia⁽²⁾, Soedarmanto Indarjulianto⁽³⁾, Hary Purnamaningsih⁽⁴⁾, Slamet Rahardjo⁽⁵⁾

(1) Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(2) Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(3) Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(4) Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(5) Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Hewan Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract

Numerous cases of acute renal failure in dogs and cats from 2004-2007 were associated with the ingestion of dog and cat pet food products and the suspected contaminant was identified as melamine and its derivatives such as cyanuric acid and melamine cyanurate. Melamine is a chemical used primarily for the manufacture of plastics, coatings, commercial filters, adhesives and compounds in the plate-making industry and kitchen appliance.But then these compounds have been abused to increase the content of nitrogen compounds in human food products and animal feed products, respectively. Increasing the content of nitrogen compounds from melamine aims to increase the value of false protein food and feed. Melamine basically has a wide security limit so it is relatively non-toxic if consumed by humans and animals. However, many studies and case reports show that melamine can cause damage to the kidneys especially if present together with cyanuric acid in the body.This paper aims to provide a simple overview and discussion in cases of damage to the urinary tract in dogs and cats that are likely caused by toxicity of melamine and its derivatives are likely to have occurred in Indonesia.

Keywords

cyanuric acid; food products; melamine cyanurate acute renal failure; toxicity

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References

Abbas, O., Lecler, B., Dardenne, P. and Baeten, V. (2013) Detection of Melamine and Cyanuric Acid in Feed Ingredients by near Infrared Spectroscopy and Chemometrics J. Near Infrared Spectrosc. 21(3): 183-194. doi: 10.1255/jnirs.1047

An, L., Li, Z., Yang, Z. and Zhang, T. (2011) Cognitive deficits induced by melamine in rats. Toxicol. Lett. 206 (3): 276–280. doi:10.1016/j.toxlet.2011.08.009

Andersen, W.C., Turnipseed, S.B., Karbiwnyk, C.M., Clark, S.B., Madson, M.R. and Gieseker, C.M. (2008) Determination and confirmation of melamine residues in catfish, trout, tilapia, salmon, and shrimp by liquid chromatography with tandem mass spectrometry. J. Agric. Food Chem. 56(12):4340-4347. doi:10.1021/jf800295z

Anonim. (2009). MELAMINE CAS N°:108-78-1. UNEP Publications. www.inchem.org/documents/sids/sids/108781.pdf

Barbee, S.J., Cascieri, T., Hammond, B.G., Inoue, T., Ishida, N., Wheeler, A.G., Chadwick, M., Hayes, D., MacCauley, M., and McComish, A. (1984). Metabolism and disposition of sodium cyanurate. Toxicologist. 4: 92

Barboza, D. and Barrionuevo A. (2007) Filler in animal feed is open secret in China. New York Times, 30 April 2007 (http://www.nytimes.com/2007/04/30/business/worldbusiness/30food.html).

Baynes, R.E., Smith, G., Mason, S.E., Barrett, E., Barlow, B.M. and Riviere, J.E. (2008) Pharmacokinetics of melamine in pigs following intravenous administration. Food Chem Toxicol. 46(3): 1196 – 1200. DOI:10.1016/j.fct.2007.11.013

Bizzari, S. and Yokose, K. (2008) Melamine. In: Chemical economics handbook. Menlo Park, CA, SRI Consulting, Inc. (http://www.sriconsulting.com/CEH/Public/Reports/673.3000/; diakses 16 Januari 2018).

Brown, C.A., Jeong, K.S., Poppenga, R.H., Puschner, B., Miller, D.M., Ellis, A.E., Kang, K.I., Sum, S., Cistola, A.M. and Brown S.A. (2007) Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007. J. Vet. Diagn. Invest. 19 (5): 525–531. DOI:10.1177/104063870701900510

Burns, K., Nolen, S., Kahler, S., Rezendes, A. (2007) Recall of pet food leaves veterinarians seeking solutions. J Am Vet Med Assoc. 230 (8):1128–1129, 1136–1138. 10.2460/javma.230.8.1126

Cheng, Y., Dong, Y., Wu, J., Yang, X., Bai, H., Zheng, H., Ren, D., Zou, Y. And Li, M. (2010) Screening melamine adulterant in milk powder with laser Raman spectrometry. Journal of Food Composition and Analysis. 23 (2): 199-202. doi.org/10.1016/j.jfca.2009.08.006

Chuenarrom, C., Daosodsai, P. and Charoenphol, P. (2014) Effect of excessive trichloroisocyanuric acid in swimming pool water on tooth erosion. Songklanakarin J. Sci. Technol. 36 (4): 445-450

Cianciolo, R.E., Bischoff, K., Ebel, J.G., Van Winkle, T.J., Goldstein, R.E. and Serfilippi, L. M. (2008) Clinicopathologic, histologic, and toxicologic findings in 70 cats inadvertently exposed to pet food contaminated with melamine and cyanuric acid. J Am Vet Med Assoc. 233(5): 729–737. doi: 10.2460/javma.233.5.729.

Clark, R. (1966) Melamine crystalluria in sheep. Journal of the South African Veterinary Medical Association. 37 (3): 349–351.

Cocchi, M., Vascellari, M., Gallina, A., Agnoletti, F., Angeletti, R. and Mutinelli, F. (2010) Canine Nephrotoxicosis Induced by Melamine-Contaminated Pet Food in Italy. J. Vet. Med. Sci. 72(1): 103–107. https://doi.org/10.1292/jvms.09-0278

Cruywagen, C.W., Stander, M.A., Adonis, M. and Calitz, T. (2009) Hot topic: Pathway confirmed for the transmission of melamine from feed to cow’s milk. J. Dairy Sci. 92 (5):2046–2050 doi:10.3168/jds.2009-2081

Ding, T., Xu, J., Li, J., Shen, C., Wu, B., Chen, H. and Li, S. (2008) Determination of melamine residue in plant origin protein powders using high performance liquid chromatographydiode array detection and high performance liquid chromatography- electrospray ionization tandem mass spectrometry. Chinese Journal of Chromatography. 26 (1):6-9.

Dobson, R.L., Motlagh, S., Quijano, M., Cambron, R.T, Baker, T.R., Pullen, A.M., Regg, B.T., Bigalow-Kern, A.S., Vennard, T., Fix, A., Reimschuessel, R., Overmann, G., Shan, Y. and Daston, G.P. (2008) Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs. Toxicol Sci. 106(1):251-262. doi: 10.1093/toxsci/kfn160Dorne, J.L., Doerge, D.R., Vandenbroeck, M., Fink-Gremmels, J., Mennes, W., K., Knutsen, H.K., Vernazza, F., Castle, L., Edler, L. and Benford, D. (2013) Recent advances in the risk assessment of melamine and cyanuric acid in animal feed. Toxicology and Applied Pharmacology 270 (3): 218-229 https://doi.org/10.1016/j.taap.2012.01.012Downes, C.J., Mitchell, J.W., Viotto, E.S. and Eggers, N.J. (1984) Determination of cyanuric acid levels in swimming pool waters by u.v. absorbance, HPLC and melamine cyanurate precipitation. Water Research 18 (3): 277-280 doi.org/10.1016/0043-1354(84)90100-3

EFSA. (2010) Scientific Opinion on Melamine in Food and Feed EFSA Panel on Contaminants in the Food Chain (CONTAM) and EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) European Food Safety Authority (EFSA), Parma, Italy. EFSA Journal 2010; 8(4):1573

El-Rabey, H.A., Al-Sieni, A.I. and Majami, A.A. (2013) The Toxic Effect of Melamine on the Kidney of Male Rats as Revealed by Biochemical and Histopathological Investigations. Life Sci J. 10(1):2119-2130.

FDA, 2008. Melamine Pet Food Recall of 2007. https://www.fda.gov/AnimalVeterinary/.../RecallsWithdrawals/ucm129575.htm

Filazi, A., Sireli, U.T., Ekici, H., Can, H.Y. and Karagoz, A. (2012) Determination of melamine in milk and dairy products by high performance liquid chromatography. J. Dairy Sci. 95(2):602-608. doi:10.3168/jds.2011-4926

Fremlin, L.J. and Pelzing, M. (2009) Melamine and cyanuric acid detection in 5 minutes using LCMS. Australia: Bruker Daltonics Division, Application note.

Garber, E.A.E. (2008) Detection of Melamine Using Commercial Enzyme-Linked Immunosorbent Assay Technology. Journal of Food Protection. 71(3): 590–594.DOI10.4315/0362-028X-71.3.590

Gonzalez, J., Puschner, B., Perez, V., Ferreras, M.C., Delgado, L., Munoz, M., Perez, C., Reyes, L.E., Velasco, J., Fernandez, V. and Garcıa-Marın, J.F. (2009) Nephrotoxicosis in Iberian piglets subsequent to exposure to melamine and derivatives in Spain between 2003 and 2006. J Vet Diagn Invest 21 (4):558–563 https://doi.org/10.1177/104063870902100425

Gossner, C.M.E., Schlundt, J., Embarek, P.B., Hird, S., Wong, D.L.F., Beltran, J.J.O., Keng Teoh, N. and Tritscher, A. (2009). The Melamine Incident: Implications for International Food and Feed Safety. Environ. Health Perspect.117(12): 1803-1808. doi: 10.1289/ehp.0900949

Hammond, B.G., Barbee, S.J.,.Wheeler, A.G., and Cascieri, T. (1985). Fundamental and Applied Toxicology. 5(4): 655–664. https://doi.org/10.1016/0272-0590(85)90189-7

Hau, A.K., Kwan, T.H., and Li, P.K. (2009) Melamine toxicity and the kidney. Journal of American Society of Nephrology. 20 (2): 245–250. doi:10.1681/ASN.2008101065

He, L., Liu, Y., Lin, M., Awika, J., Ledoux, D.R., Li, H. And Mustapha, A. (2008) A new approach to measure melamine, cyanuric acid, and melamine cyanurate using surface enhanced Raman spectroscopy coupled with gold nanosubstrates. Sens. & Instrumen. Food Qual. 2: 66–71. doi:10.1007/s11694-008-9038-0

Huthmacher, K., and Most, D. (2005) Cyanuric Acid and Cyanuric Chloride. Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH, Weinheim. doi 10.1002/14356007.a08 191

Ingelfinger, J.R. (2008) Melamine and the Global Implications of Food Contamination. N Engl. J. Med. 359:2745-2748. DOI: 10.1056/NEJMp0808410

International Agency for Research on Cancer. [IARC] (2010). Monograph on the Evaluation of the Carcinogenik Risk of Chemicals to Man. Geneva. WHO. IARC. Monographs Vol.73. http://monographs.iarc.fr/ ENG/Monographs/ vol73/mono73-17.pdf

Ji, A.L., Wong, Y.L., Cai, T.J. and Liu, J. (2014) Infant formula safety concerns and consequences in China. World J Pediatr. 10 (1): 7-9. doi: 10.1007/s12519-014-0447-3

Kobayashi, T., Okada, A., Ando, R., Tozawa, K., Kohri, K. and Yasui, T. (2016) MP58-13 The Mechanism Of Renal Stone Formation And Renal Failure Induced By Melamine And Cyanuric Acid; Longterm Experiment Results. The Journal Of Urology. 195 (4): Supplement, e781. DOI: https://doi.org/10.1016/j.juro.2016.02.811

Krotz, L., Cicerci, E. and Giazzi, G. (2008) Protein determination in cereals and seeds. Food Quality 15(4):37–39.

Kumar, A., and Katiyar, V. (1990) Modelling and experimental investigation of melamine formaldehyde polymerization. Macromolecules 23 (16): 3729–3736. DOI: 10.1021/ma00218a003

Lam, H.S., Ng, P.C., Chu, W.C., Wong, W., Chan, D.F., Ho, S.S., Wong, K.T., Ahuja, A.T. and Li, C.K. (2008) Renal screening in children after exposure to low dose melamine in Hong Kong: cross sectional study. BMJ. ;337:a2991. doi.org/10.1136/bmj.a2991

Lee, C.H., Ooi, P.T., Sheikh Omar, A.R. and Lim, B.K. (2011) Melamine Toxicity in Pigs. Pertanika J. Trop. Agric. Sci. 34 (1): 175-179

Lewin-Smith, M.R., Kalasinsky, V.F., Mullick, F.G., Thompson, M.E. (2009) Letters to the Editor : Melamine-Containing Crystals in the Urinary Tracts of Domestic Animals: Sentinel Event?. Arch Pathol Lab Med. 133 (3): 341-342. DOI:10.1043/1543-2165-133.3.341

Lin, M., He, L., Awika, J., Yang, L., Ledoux, D. R., Li, H. And Mustapha, A. (2008) Detection of melamine in gluten, chicken feed and processed foods using surface enhanced Raman spectroscopy and HPLC. Journal of Food Science. 73(8): T129–T134.DOI:10.1111/j.1750-3841.2008.00901.x

Lipschitz, W.L. and Stokey, E. (1945) The Mode Of Action Of Three New Diuretics: Melamine, Adenine And Formoguanamine. Journal of Pharmacology and Experimental Therapeutics. 83 (4) 235-249.

Liu, Y., Deng, J., An, L., Liang, J., Chen, F. And Wang, H. (2011) Spectrophotometric determination of melamine in milk by rank annihilation factor analysis based on pH gradual change-UV spectral data. Food Chemistry. 126 (2): 745-750. doi.org/10.1016/j.foodchem.2010.11.057

Liu, G., Li, S., Jia, J., Yu, C., He, J., Yu, C. and Zhu. J. (2010) Pharmacokinetic study of melamine in rhesus monkey after a single oral administration of a tolerable daily intake dose. Regulatory Toxicology and Pharmacology. 56 (2):193–196. doi:10.1016/j.yrtph.2009.09.014

Liu, Y., Todd, E.D., Zhang, Q., Shi, J.R. and Liu, X.J. (2012) Recent developments in the detection of melamine. J Zhejiang Univ Sci B 13(7): 525-532. J Zhejiang Univ Sci B. 13(7): 525–532. doi: 10.1631/jzus.B1100389

Lutter, P., Perroud, M.C.S., Gimenez, E.C., Meyer, L., Goldmann, T., Bertholet, M.C., Mottier, P., Desmarchelier, A., Florence, M., Perrin, C., Robert, F. and Delatour, T. (2011) Screening and confirmatory methods for the determination of melamine in cow’s milk and milk-based powdered infant formula: validation and proficiency-test of ELISA, HPLC-UV, GC-MS and LC-MS/MS. Food Control. 22(6) :903-913. https://doi.org/10.1016/j.foodcont.2010.11.022

MacKenzie, H.I. (1966) Melamine for sheep. J. S. Afr. Vet. Med. Ass. 37(2): 153-157.

Mast, R.W., Jeffcoat, A.R., Sadler, B.M., Kraska, R.C. and Friedman, M.A. (1983) Metabolism, disposition and excretion of [14C]melamine in male Fischer 344 rats. Food Chem Toxicol 21(6): 807–810. DOI10.1016/0278-6915(83)90216-8

Maxwell, G.R. (2007) Synthetic nitrogen products. In: Kent and Riegel’s handbook of industrial chemistry and biotechnology, 11th ed. New York, NY, Springer, pp. 996–1085.

Melnick, R.L., Boorman, G.A., Haseman, J.K., Montali, R.J. and Huff, J. (1984) Urolithiasis and bladder carcinogenicity of melamine in rodents. Toxicol Appl Pharmacol. 72 (2): 292–303. https://doi.org/10.1016/0041-008X(84)90314-4

Meng, Z., Shi, Z.H., Liang, S.X., Dong, X.F., Lu, Y.K. and Sun, H.W. (2015) Rapid screening and quantification of cyromazine, melamine, ammelide, ammeline, cyanuric acid, and dicyandiamide in infant formula by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and triple quadrupole mass spectrometry. Food Control. 55:158-65. https://doi.org/10.1016/j.foodcont.2015.02.034

Miao, H., Fan, S., Wu, Y.N., Zhang, L., Zhou, P.P., Li,J.G., Chen, H.J. and Zhao, Y.F. (2009) Simultaneous determination of melamine, ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography-tandem mass spectrometry. Biomed Environ Sci. 22(2):87-94. doi: 10.1016/S0895-3988(09)60027-1

Montesano, D., Gennari, O., Festa, C., Zollo, F., Seccia, S. and Albrizio, S. (2013) A Simple HPLC-DAD Method for the Analysis of Melamine in Protein Supplements: Validation Using the Accuracy Profiles. Journal of Chemistry. 2013: 1-7,.doi.org/10.1155/2013/239342

Moore, J.C., DeVries, J.W., Lipp, M., Griffiths, J.C. and Abernethy, D.R. (2010) Total Protein Methods and Their Potential Utility to Reduce the Risk of Food Protein Adulteration. Comprehensive Reviews in Food Science and Food Safety 9 (4): 330-357. doi 10.1111/j.1541-4337.2010.00114.x

Newton, G. L. and Utley, P.R. (1978) Melamine As A Dietary Nitrogen Source For Ruminants. J. Anim. Sci. 47 (6): 1338-1344. https://doi.org/10.2527/jas1978.4761338x

Nilubol, D., Pattanaseth, T., Boonsri, K., Pirarat, N. and Leepipatpiboon, N. (2009) Melamine- and Cyanuric Acid–Associated Renal Failure in Pigs in Thailand. Vet Pathol 46 (6):1156–1159 (2009) DOI: 10.1354/vp.08-VP-0233-N-FL

NTP (National Toxicology Programme), 1983. Carcinogenesis bioassay of melamine (CAS No. 108- 78-1) in F344/N rats and B6C3F1 mice (feed study). Research Triangle Park, NC, and Bethesda, MD, United States Department of Health and Human Services, Public Health Service, National Institutes of Health, National Toxicology Program (NTP Technical Report Series No. 245; NTP- 81-86; NIH Publication No. 83-2501; Available from http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr245.pdf). National Toxicology Program technical Report Series. 245, 1-171.

Nururrozi, A., Indarjulianto, S., Yanuartono, Widyarini, S. 2018. Potensi Urine Acidifier untuk Mencegah Struvite Activity Prodcut (SAP) pada Kasus Feline Lower Urinary Tract Disease (A case report). Journal Veteriner (submitted)

Park, B.D. and Jeong, H.W. (2010) Cure kinetics of melamine-formaldehyde resin/clay/cellulose nanocomposites. J. Ind. Eng. Chem. 16 (3): 375–379. https://doi.org/10.1016/j.jiec.2010.01.035

Peng, J. , Li, D., Chan, Y.K., Chen, Y.,. Lamb, J.R., Tam, P.K. and El-Nezami, H. 2012. Effects of water uptake on melamine renal stone formation in mice. Nephrol Dial Transplant. 27 (6): 2225–2231 doi: 10.1093/ndt/gfr577

Puschner, B., Poppenga, R.H., Lowenstine, L.J., Filignezi, M.S.and Pesavento, P.A. (2007) Assessment of melamine and cyanuric acid toxicity in cats. Journal of Veterinary Diagnostic Investigation. 19(6): 616-624. DOI:10.1177/104063870701900602

Puschner, B. and Reimschuessel, R. (2011) Toxicosis caused by melamine and cyanuric acid in dogs and cats:uncovering the mystery and subsequent global implications. Clin Lab Med. 31(1): 181-199. doi: 10.1016/j.cll.2010.10.003.

Qiu, Y. and Gao, L. (2005) Blue-emitting cyanuric acid-melamine complexes from urea thermolysis. Materials Research Bulletin. 40 (5): 794-799. https://doi.org/10.1016/j.materresbull.2005.02.003

Reimschuessel, R., Evans, E.R., Stine, C.B., Hasbrouck, N., Mayer, T.D., Nochetto, C. and Gieseker, C.M. (2010) Renal crystal formation after combined or sequential oral administration of melamine and cyanuric acid. Food Chem. Toxicol. 48 (10): 2898–2906. doi: 10.1016/j.fct.2010.07.024

Reimschuessel, R., Gieseker, C.M., Miller, R.A., Ward, J., Boehmer, J., Rummel, N., Heller, D.N., Nochetto, C., Turnipseed, S.B., Karbiwnyk, C.M., Satzger, R.D., Crowe, J.B., Wilber, N.R., Reinhard, M.K., Roberts, J.F. and Witkowski, M.R. (2008) Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs. Am J Vet Res. 69 (9):1217–1228. https://doi.org/10.2460/ajvr.69.9.1217

Reyers, F. (2008) Melamine is back. In milk and in South Africa. A veterinary perspective. Veterinary News, December issue.

Schaber, P.M., Colson, J., Higgins, S., Dietz, E., Thielen, D., Anspach, B. and Brauer, J. (1999) Study of the thermal decomposition of urea (pyrolysis) reaction and importance to cyanuric acid production. American Laboratory. 31(16): 13-21

She, D.M., Yu, H.L., Huang, Q.L., Li, F.M. and Li, C.J. (2010) Liquid-Phase Synthesis of Cyanuric Acid from Urea. Molecules, 15 (3): 1898-1902; doi:10.3390/molecules15031898

Shen, J.S., Wang, J.Q., Wei, H.Y., Bu, D.P., Sun, P. And Zhou, L.Y. (2010) Transfer efficiency of melamine from feed to milk in lactating dairy cows fed with different doses of melamine. J Dairy Sci. 93 (5) :2060–2066. DOI:10.3168/jds.2009-2590

Skinner, C.G., Thomas, J.D. and Osterloh, J.D. (2010) Melamine Toxicity. J. Med. Toxicol. 6(1):50–55 DOI 10.1007/s13181-010-0038-1

Straková, E., Karásková, K., Zapletal, D. And Suchý, P. (2014) Effect of melamine and cyanurid acid contaminated diets on blood indicators in broiler chickens. Czech J. Anim. Sci. 59 (12): 564–570.

Suchý, P., Straková, E., Herzig, I., Staňa, J., Kalusová,R. and Pospíchalová, M. (2009) Toxicological risk of melamine and cyanuric acid in food and feed. Interdiscip Toxicol. 2(2): 55–59. doi: 10.2478/v10102-009-0010-6

Sugita, T., Ishiwata, H. and Yoshihira, K. (1990) Release of formaldehyde and melamine from tableware made of melamine-formaldehyde resin. Food Addit. Contam. 7(1):21-27. DOI:10.1080/02652039009373815

Thompson, M. E., Lewin-Smith, M. R., kalasinsky, V. F. Pizzolato, K. M., Fleetwood, M. L., Mcelhaney, M. R. and Johnson, T. O. (2008) Characterization of Melamine-containing and Calcium Oxalate Crystals in Three Dogs with Suspected Pet Food–induced Nephrotoxicosis. Vet Pathol. 45(3):417-426. DOI:10.1354/vp.45-3-417

Vail, T., Jones, P.R. and Sparkman, O.D. (2007) Rapid and unambiguous identifi cation of melamine in contaminated pet food based on mass spectrometry with four degrees of confirmation. J Anal Toxicol. 31(6): 304–312. DOI10.1093/jat/31.6.304

Wang, I.J., Wu, Y.N., Wu, W.C., Leonardi, G., Sung, Y.J., Lin, T.J., Wang, C.L., Kuo, C.F., Wu, K.Y., Cheng, W.C., Chan, C.C., Chen, P.C. and Lin, S.L. (2009) The association of clinical findings and exposure profiles with melamine associated nephrolithiasis. Arch Dis Child. 94(11):883–887. DOI:10.1136/adc.2009.163477

Wei, R., Wang, R., Zeng, Q., Chen, M. and Liu, T. (2009) High-Performance Liquid Chromatographic Method for the Determination of Cyromazine and Melamine Residues in Milk and Pork. Journal of Chromatographic Science. 47 (7) :581-584.DOI10.1093/chromsci/47.7.581

Weise, E. (2007) Poison pet food woes seem to hit cats harder. USA Today. http://www.usatoday.com/tech/science/2007-05-07-poison-petfood-science_N.htm. Retrieved 2008-10-01.

Whitten, M.C. and Lin , C.T. (1999) Coating Performance of Polyester−Melamine Enamels Catalyzed by an in Situ Phosphatizing Reagent on AluminumInd. Eng. Chem. Res. 38 (10): 3903–3910. DOI: 10.1021/ie990231i

WHO. (2008) Melamine and Cyanuric acid: Toxicity, Preliminary Risk Assessment and Guidance on Levels in Food 25 September 2008. - Updated 30 October 2008. www.who.int/foodsafety/fs_management/Melamine.pdf

Xie, G., Zheng, X., Qi, X., Cao, Y., Chi, Y., Su, M., Ni, Y., Qiu, Y., Liu, Y., Li, H., Zhao, A. and Jia, W. (2010) Metabonomic Evaluation of Melamine-Induced Acute Renal Toxicity in Rats. J. Proteome Res. 9 (1):125–133 DOI: 10.1021/pr900333h

Yan, N., Zhou, L., Zhu, Z. and Chen, X. (2009) Determination of Melamine in Dairy Products, Fish Feed, and Fish by Capillary Zone Electrophoresis with Diode Array Detection. J. Agric. Food Chem. 57 (3): 807–811. DOI: 10.1021/jf803429eYang, H.H., Zhou, W.H., Guo, X.C., Chen, F.R., Zhao, H.Q., Lin, L.M. and Wang, X.R. (2009) Molecularly imprinted polymer as SPE sorbent for selective extraction of melamine in dairy products. Talanta. 80(2):821–825. doi: 10.1016/j.talanta.2009.07.067.

Yokley, R.A., Mayer, L.C., Rezaaiyan, R., Manuli, M.E. and Cheung, M.W. (2000) Analytical method for the determination of cyromazine and melamine residues in soil using LC-UV and GC-MSD. J Agric Food Chem. 48(8):3352-8. DOI: 10.1021/jf991231w

Yu, H., Tao, Y., Chen, D., Wang, Y., Liu, Z., Pan, Y., Huang, L., Peng, D., Dai, M., Liu, Z. And Yuan, Z. (2010) Development of high performance liquid chromatography method and liquid chromatography-tandem mass spectrometry method with pressurized liquid extraction for simultaneus quantification and confirmation of cyromazine, melamine and its metabolites in foods of animal origin. Anal Chim Acta. 682 (1-2): 48-58. DOI:10.1016/j.aca.2010.09.032

Zheng, X., Zhao, A., Xie, G., Chi, Y., Zhao, L., Li, H., Wang, C., Bao, Y., Jia, W., Luther, M., Su, M., Nicholson, J.K. and Jia, W. (2013) Melamine-induced renal toxicity is mediated by the gut microbiota. Sci Transl Med. 5(172):1-5 doi: 10.1126/scitranslmed.3005114.

DOI: https://doi.org/10.22146/jsv.48601