ARTIFICIAL INFECTION STUDY OF FASCIOLA GIGANTICA IN LOCAL SHEEP AND ITS IMPACT ON WEIGHT GAIN, HEMATOLOGY AND ENZYME GAMMA GLUTAMYL TRANSFERASE

Abstract

This research was to investigate the effect of infection of Fasciola
gigantica on weight gain, blood picture and the level of iiver damage of local
sheep, and the correlation between the number of metacercariae infectH and
the number of the fluke recovered.                                                                          

Twenty male local sheep, were allocated randomly into 4 different
groups. One group used as uninfected control and a total of 200, 500 and
1.000 metacercariae was infected into animals of groups 2, 3 and 4,
respectively. Variables evaluated include weight gain, blood picture, gamma
glutamyl tons/erase (GGTase) activity, and the number of egg and the fluke
recovered. All individual sheep were weighed every week, whole blood and
sera were taken every 3 weeks, fecal samples were started to b« examined 8
weeks after infection and every week thereafter. Weight gain, hematology
picture and enzyme GGTase activity were anafized by split-plot, the number
of egg and fluke recovered were analized by correlation. All sheep were killed
18 weeks after infection.                         

The results show that infection F. gigantica causes norntocytic normochromic anemia in local sheep. Increased GGTase acitivity is observed. The number of fluke recovered correlates with the number of metacercariae infected.