Angi Nadya Bestari(1*), T.N. Saifullah Sulaiman(2), Abdul Rohman(3)

(1) Fakultas Farmasi, Universitas Gadjah Mada
(2) Fakultas Farmasi, Universitas Gadjah Mada
(3) Fakultas Farmasi, Universitas Gadjah Mada
(*) Corresponding Author


Meloxicam is one of the most commonly prescribed anti-inflammatory drugs which is widely consumed by elderly patients. Meanwhile, elderly patients often have difficulty in consuming conventional tablets. Orally disintegrating tablet (ODT) is a solid dosage form that quickly dissolves when placed on the tongue and is expected to be the solution for patients who have difficulty consuming conventional tablets. The research aimed to formulate ODT meloxicam with a variation of superdisintegrant agent, Ac-Di-Sol and Kollidon CL, and obtain the superdisintegrant agent composition of the optimum formula. ODT contained 7,5 mg meloxicam as the active ingredient and excipients were included of Ac-Di-Sol and Kollidon CL as superdisintegrant agent, Avicel PH 102 as a filler binder, and magnesium stearate and talcum as a lubricant. Design Expert 7.1.5 software helped to determine the formula and optimum formula based on the composition of superdisintegrant agent, Ac-Di-Sol and Kollidon CL. ODT was made by direct compression method and was evaluated its physical properties of granul and tablet. The data then compared with the literature and analyzed later to get the optimum formula. The results showed that Kollidon CL could accelerate the disintegration time, while Ac-Di-Sol prolonged the disintegration time of ODT. The formula which consists of 4,5 mg Ac-Di-Sol and 10,5 mg Kollidon CL had DE60 93,12%. The optimum formula consisted of 5,4 mg Ac-Di-Sol and 9,6 mg Kollidon CL which resulted in 4,1 kg hardness response, 0,47% friability, 23 seconds disintegration time, and 19 seconds wetting time.


meloxicam, orally disintegration tablet (ODT), Ac-Di-Sol, Kollidon CL

Full Text:



Allen, L.V., Popovich, N.G. dan Ansel, H.C. 2011, Ansel’s Dossage Forms and Drug Delivery Systems, 9th Ed., Lippinkott Williams and Wilkins, Philadelphia. Balasubrmaniam, J. 2009, Influence of Superdisintegrants on The Rate of Drug Dissolution from Oral Solid Dosage Forms, Pharmaceutical Technology, April. Bhowmik, D., Chiranjib, B., Krishnakanth, Pankaj and Chandira, R.M. 2009, Fast Dissolving Tablet: An Overview, Journal Chemical Pharmaceutics. Res, 1: 163-177. Departemen Kesehatan, 1979, Farmakope Indonesia, Edisi Ketiga, Jakarta, Departemen Kesehatan Republik Indonesia. Departemen Kesehatan, 1995, Farmakope Indonesia, Edisi IV, Jakarta, Departemen Kesehatan Republik Indonesia. Department of Health, 2009, British Pharmacopoiea, The Departement of Health, London. Goodman, G.A. 1997, The Pharmacological Basis of Therapeutic, pp 447-448, McGraw-Hill, New York, United States America. Gupta, A. and Dubey, P. K. 2012, Solubility Enhancement of Meloxicam and Formulation Development of Rapid Disintegrating Tablet of Meloxicam, International Journal of Pharmaceutical and Medicinal Sciences, 1: 1-20. Hansen, K.E. and Elliot, M. E. 2005, Osteoarthritis, Pharmacotherapy A Pathophysiological Approach. Jain, C. P. And Naruka, P. S. 2009, Formulation and Evaluation of Fast Dissolving Tablets of Valsartan, International Journal of Pharmacy and Pharmaceutical Sciences, 1: 219-221. Kibbe, A.H., 2009, Crospovidone, dalam Rowe, R.C, Sheskey, P.J., Quinn, M.E., (Eds.), Handbook of Pharmaceutical Excipients, 6th Edition, 208-209, Pharmaceutical Press and American Pharmacists Association, USA. Kim, H. and Lee, I. 2007, A Novel Drug Delivery System Design for Meloxicam, JPharm Pharmaceut Sci, 10 (3): 288-298. Kornblum, S. And Stopak, S.A. 2001, A New Tablet Disintegrating Agent: Crosslinked Polyvinyl Pyrrolidone, J Am Pharm Assoc, 41 (2): 229-272. Koseki, T., Onishi, H., Takahashi, Y., Uchida, M. and Machida, Y. 2008, Development of A Novel Fast Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Ester as A Disintegration Accelerating Agent, Journal Chemical Pharmaceutics, 56 (10): 1.384-1.388. Kumar, G. P. and Nirmala, R. 2012, Fundamental Aspects of Superdisintegrants: a Concise Review, Journal of Global Pharma Technology, 4 (2), 1-12. Kundu, S. and Sahoo, P. K. 2008, Recent Trend in The Development of Orally Disintegration Tablet Technology, Pharma Times, 40 (4): 1-5. Manivannan, R. 2009, Oral Disintegrating Tablets: A Future Compaction, International Journal of Pharmaceutical Research and Development-Online, 10: 1-10. Obaidat, A. A., Khanfar, R. A. and Khawam, M. N. 2009, The Effect of β-Cyclodextrin on The Solubility and Dissolution Rate of Meloxicam and Investigation of The Driving Force for Complexation Using Molecular Modeling, J. Incl. Phenom. Macrocycl. Chem., 63: 273-279. Panigrahi R. and Behera, S. 2010, A Review of Fast Dissolving Tablets, Webmed Central, 1 (9): 117. Singh, J. and Singh, R. 2009, Optimization and Formulation of Orodispersible Tablets of Meloxicam, Tropical Journal of Pharmaceutical Research, 8 (2): 153-159. United States Pharmacopeial Convention, 2008, United States Pharmacopeaa 32, United States Pharmacopeial Convention, Maryland. Verma, R.K. and Garg, S. 2001, Current Status of Drug Delivery Technologies and Future Directions, Pharmaceutical Technology, 25: 9–10.

DOI: https://doi.org/10.22146/farmaseutik.v12i2.26454

Article Metrics

Abstract views : 2853 | views : 22160


  • There are currently no refbacks.

Majalah Farmaseutik Indexed by:

Creative Commons License