Formula Optimization and Activity Test In Vitro Lotion O/W Ethanolic Extract of Mangga Temperature (Curcuma Mangga Val. and Van Zijp) as Solar Tables

Mercy Arizona; A. Karim Zulkarnain

doi:10.22146/farmaseutik.v14i1.41926

Formula Optimization and Activity Test In Vitro Lotion O/W Ethanolic Extract of Mangga Temperature (Curcuma Mangga Val. and Van Zijp) as Solar Tables

https://doi.org/10.22146/farmaseutik.v14i1.41926

Mercy Arizona⁽¹⁾, A. Karim Zulkarnain^(2*)

(1) Fakultas Farmasi UGM Yogyakarta
(2) Fakultas Farmasi UGM Yogyakarta
(*) Corresponding Author

Abstract

Intersection mango extract (Curcuma mango Val.) Has activity as a sunscreen by spectrophotometry. This study aims to determine the optimum formula lotion o/w, properties and physical stability of the optimum formula lotion o/w, and the activities of the optimum formula sunscreen lotion o/w Intersection mango extract (Curcuma mango Val.) by spectrophotometry. The optimum formula was obtained by the method Simplex Lattice Design (SLD). Responses are used to determine the optimum formula is the bonding strength and viscosity. Physical stability lotion o/w at room temperature include tests dispersive power, adhesion, and viscosity, as well as freeze thaw cycling test. Activities sunscreen lotion o/w determined by spectrophotometry to determine the Sun Protecting Factor (SPF),% transmission erythema, and% transmission pigmentation. Data were analyzed by One Way ANOVA and t test. The results showed that the optimum formula lotion o/w on a combination of 5% triethanolamine (TEA) -stearat and 5% cetyl alcohol. Lotion o/w intersection mango extracts have had the scatter 63.21 ± 2.69 cm2, the stickiness of 2.32 ± 0.15 seconds, and the viscosity of 133.5±8.05 dPas. Results of statistical analysis showed that the lotion o/w has good stability. Lotion o/w has activity as a sunscreen lotion at concentrations o/w 12.5% are indicated with an SPF value of 12.82 ± 0.16 and ineffective in the protection against erythema and pigmentation.

Keywords

Curcuma mango, lotion, SLD, sunscreen

Full Text:

PDF

References

Abas, F., Lajis, N.H., Shaari, K., Israf, D.A., Stanslas, J., Yusuf, U.K., & Raof, S.M., 2005, A labdane diterpene glucoside from the rhizomes of Curcuma mangga, J. Nat. Prod.68, 1090–1093. Anonim, 2003, Sun Protection: A Primary Teaching Resource, , 5, World Health Organization, Jenewa. Anonim, 2005, ASEAN Guideline on Stability Study of Drug Product, 34, ASEAN, Filipina. Anonim, 2015, Kamus Kesehatan, http://kamuskesehatan.com/arti/tabir-surya/, Diakses tanggal 28 Februari 2015. Arakane, K. N., 2016, UV Care., dalam R. J. Sivamani, Cosmeceuticals and Active Cosmetics Third Edition, 281-296, Boca Raton: CRC Press. Balsam, M. S., 1972, Cosmetics: Science and Technology, 2nd Ed., Vols. 1-3 Interscience Publishers, Inc, New York. . Buhse, L. Kolsinki, R., Westenberger, B., Wokovich, A., Spencer, J., Chen, C.W., Turujman, S., Gautam-Basak, M., Kang, G.J., Kibbe, A., Heintzelman, B., Wolfgang, E., 2005, Topical Drug Classification, International Journal of Pharmaceutics, 295, 101-112. Couturaud, V., 2009, Biophysical Characteristics of the Skin in Relation to Race, Sex, Age, and Site, dalam A. P. Barel, Handbook of Cosmetics Science and Technology, 3rd edition, New York, Informa Healthcare. Cumpelik, B., 1972, Analytical Procedures and Evaluation of Sunscreens, J.Soc. Cosmt. Chem., 23, 333-345. Elmarzugi, N.A. Keleb, E. I. Mohamed, A.T. Issa, Y.S. Hamza, A.M. Layla, A.A. Salama, M. Bentaleb, A.M., 2013, The Relation between Sunscreen and Skin Pathochanges Mini Review, International Journal of Pharmaceutical Science Invention, 2(7), 43-52. Iwata, H. S., 2013, Formulas, Ingredients and Production of Cosmetics: Technology of Skin and Hair Care Products in Japan, 39-67, Springer, Tokyo. Jones, D., 2008, Pharmaceutical Dosage Form and Design, 86, Pharmaceutical Press, London. Levy, S., 2009, skin Care Products: Artificial Tanning, dalam A. P. Barel, Handbook of Cosmetic Science and Technology, Third Edition, 339-344, Informa Healthcare New York. Liverman, L. M., 2009, Mechanisms of Skin Hydration, dalam A. P. Barel, Handbook of Science and Technology, Third edition, 91-106, Informa Healthcare, New York. Mansur, J.D.D, Breder, M.N.R., Mansur, M.C.D.A., Azulay, R.D., 1986, Determinac¸ ãodo fator de protec¸ ão solar por espectrofotometria, An. Bras. Dermatol, 61, 121–124 cit Costa, S.C.C., Detoni, C.B., Branco, C.R.C., Botura, M.B., Branco, A., 2015, In vitro photoprotective effects of Marcetia taxifolia ethanolic extract and its potential for sunscreen formulations, Brazilian Journal of Pharmacognosy, 25, 413-418. Mitsui, T., 1997, New Cosmetic Science, 13, 319, 336, Elsevier Science B.V, Amsterdam. Mollet, H & Grubenmann, A., 2001, Formulation Technology : Emulsions, Suspensions, Solid Form, 261-262, Wiley-Vch, Toronto. Murphy, E., 2005, The Final Monograph, dalam N. Shaath, Sunscreens Regulation and Commercial Development, Third edition, 96-114, Taylor & Francis, Boca Raton. Nash, J. T., 2006, Sunscreens, dalam Z. T. Draelos, Cosmetic Formulation of Skin Care Products, 135-151, Taylor & Francis, New york. Niazi, S.K., 2004, Handbook of Pharmaceutical Manufacturing Formulations, Semisolid Products, Voulme 4, CRC Press, Boca raton. Pujimulyani, D. R., 2013, The Phenolic Substances and Antioxidant Activity of White Saffron (Curcuma mangga Val.) as affected by Blanching Methods, International Journal of Biological, Biomolecular, Agricultural, Food and Biotechnological Engineering, 7(10), 600-603. Setyaningrum, A., Andriani., Yani, F., 2013, Potensi Temu Mangga (Curcuma mangga val.) Sebagai Minuman Fungsional, Teknosains PanganI, 2, 27-33. Shaath, N., 2005, The Chemistry of Ultraviolet Filters, dalam N. Shaath, Sunscreens Regulations and Commercial Development Third Edition, 227, Taylor & Francis Group, New York . Stanfield, J., 2005, In Vitro Techniques in Sunscreen Development, dalam N. Shaath, Sunscreens Regulations and Commercial Development, Third Edition, 854-880, Taylor & Francis, Boca Raton. Sumarny, R., Djamil, R., Indira, A., 2012, Kadar Kurkumin dan Potensi Antioksidan Ekstrak Etanol Rimpang Temu Putih (Curcuma zedoaria (Berg) Roscoe.), Temu Mangga (Curcuma mangga Val et Zyp.) dan Temulawak (Curcuma xanthorrhiza Roxb), Jurusan Farmasi Fakultas MIPA, Universitas Jenderal Achmad Yani, Cimahi. Suwandi, A.O., Pramono, S., Mufrod, 2012, Pengaruh Konsentrasi Ekstrak Daun Kepel (Stelechocarpus burahol (BL) Hook f. & Th.) Terhadap Aktivitas Antioksidan dan Sifat Fisik Sediaan Krim, Majalah Obat Tradisional, 17(2), 27-33. Tortora, G. D., 2009, Principles of Anatomy and Physiology, Twelfth Edition. 148-152, John Wilwy & Sons, Inc, U.S.A. Voigt, R., 1995, Buku Pelajaran Teknologi Farmasi, diterjemahkan oleh Soendani Noerono Soewandhi, 566,580, Gadjah Mada University Press, Yogyakarta. Yuliani, H. S., 2010, Optimasi Kombinasi Campuran Sorbitol, Gliserol, dan Propilenglikol dalam Gel Sunscreen Ekstrak Etanol Curcuma mangga, Majalah Farmasi Indonesia, 2(2), 83-89.

DOI: https://doi.org/10.22146/farmaseutik.v14i1.41926