Evaluasi Kesesuaian Dosis dan Clinical Outcome Amikasin dan Gentamisin di Picu (Pediatric Intensive Care Unit) RSUP Dr. Sardjito Yogyakarta

https://doi.org/10.22146/farmaseutik.v1i1.59233

Novrilia Atika Nabila(1), Ika Puspitasari(2*), Ida Safitri Laksanawati(3)

(1) 1. Mahasiswa Magister Farmasi Klinik, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta, Indonesia
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) 3. Divisi Infeksi Dan Penyakit Tropis, Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran UGM/RSUP Dr. Sardjito, Yogyakarta, Indonesia
(*) Corresponding Author

Abstract


Pemakaian amikasin dan  gentamisin yang memiliki kisaran terapi sempit perlu dilakukan monitoring terapi. Monitoring terapi dilakukan melalui tinjauan secara farmakokinetika dengan menghitung estimasi kadar. Penelitian ini bertujuan untuk melihat estimasi kadar amikasin dan gentamisin pada pasien PICU (Pediatric Intensive Care Unit) dan mengetahui hubungannya terhadap outcome klinis pasien serta kejadian nefrotoksisitas. Penelitian ini merupakan penelitian observational dengan desain cross sectional. Subjek penelitian ini adalah pasien pediatrik yang di rawat di PICU RSUP Dr. Sardjito Yogyakarta periode 2017 – 2019. Jumlah pasien yang memenuhi kriteria inklusi dan eksklusi sebanyak 54 pasien. Hasil estimasi kadar diamati berdasarkan 2 parameter PK-PD yaitu kesesuaian rasio Cmax/MIC dan Cmin>MIC. Hasil dari penelitian ini menunjukkan pada penggunaan amikasin mencapai target rasio Cmax/MIC 17 (74%), dan Cmin > MIC yaitu 3 (13%) pasien. Pada penggunaan gentamisin mencapai target rasio Cmax/MIC 16 (46%), Cmin > MIC yaitu 7 (20%) pasien. Hasil analisis dengan uji Fisher menunjukkan tidak terdapat hubungan yang signifikan kedua parameter tersebut terhadap outcome klinis dengan nilai p > 0.05. Kesesuaian estimasi kadar tidak berpengaruh secara signifikan terhadap kejadian nefrotoksisitas. Tanda-tanda nefrotoksisitas terdapat pada 3 pasien (6%).


Keywords


Estimasi Kadar; Amikasin dan Gentamisin; Pasien PICU; Outcome Klinis; Nefrotoksisitas

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DOI: https://doi.org/10.22146/farmaseutik.v1i1.59233

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