Karakteristik Toksisitas Hidroksiapatit yang Disintesis dari Kalsit Terhadap Rattus norvegicus

Abstract

The use of synthetic hydroxyapatite (HA) in biomedical application is well warranted. It has shown to have
an excellent biocompatibility in human tooth and bones. The present study was conducted to know the toxicity
characteristics of hydroxyapatite synthesized from Mojokerto calcite in Rattus norvegicus. In this study 30
Rattus norvegicus were used as experimental animals. The animals were divided into 3 groups (n=10) to be given
HA-calcite, HA-200 (Waco, Japan), and aquadest (control) orally. The animals were observed 7 days and then
were analyzed for: fatality rate and clinical behavior, hematology test, organ morphology, and histopathology
appearance. The result showed that there was not any animal death during 7 days observation. None of the animal
exhibited any noteworthy findings in clinical behavior, hematology test, organ morphology, and histopathology
appearance. In conclusion, HA-calcite did not show any acute toxicity characteristic; therefore, it was potential to
be used as an alternative material for bone substitution.