Application of Factorial Design for Optimization of PVC-HPMC Polymers in Matrix Film Ibuprofen Patch-Transdermal Drug Delivery System

  • Galih Pratiwi Department of Pharmacy, STIKES ‘Aisyiyah Palembang, Sumatera Selatan Indonesia, 30152
  • Susi Susanti Department of Pharmacy, STIKES ‘Aisyiyah Palembang, Sumatera Selatan Indonesia, 30152
  • Shaum Shiyan Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Indralaya (OI) Sumatera Selatan Indonesia, 30662
Keywords: Ibuprofen, optimization, design of experiment, factorial design, PVP, HPMC, transdermal patch


Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) class of drugs, and oral use can cause side effects. Transdermal patch dosage forms are useful for minimizing side effects on oral administration. Transdermal patches are formulated using a special membrane that can control drug release in the matrix system. This study was intended to determine the characteristics of the resulting patch, the optimum composition of the formula, and the profile of the release of transdermal ibuprofen release. The film matrix optimization on the ibuprofen patch formulation uses design of experiment (DoE) approach using factorial design 22. The mixture of polyvinyl pyrrolidone (PVC) and hydroxypropyl methylcellulose (HPMC) components gives a pleasant texture, and the release results in vitro show a proper and controlled release of the ibuprofen patch. Based on the research, it can be concluded that the patch has excellent characteristics with a good texture so that the development time is long with the optimum formula of chitosan and HPMC, as well as having a proper and controlled release profile.


1 Madhulatha, A.; Naga, R. T. Formulation and Evaluation of Ibuprofen Transdermal Patches. Int J Res Pharm Biomed Sci 2013, 4 (1), 351–362.
2 Rasool, B.; Abu-Gharbieh, E.; Fahmy, S.; Saad, H.; Khan, S. Development and Evaluation of Ibuprofen Transdermal Gel Formulations. Trop J Pharm Res 2010, 9 (4), 355–363.
3 Prausnitz, M. R.; Langer, R. Transdermal Drug Delivery. Nat Biotechnol 2008, 26 (11), 1261–1268.
4 Tombs, E. L.; Nikolaou, V.; Nurumbetov, G.; Haddleton, D. M. Transdermal Delivery of Ibuprofen Utilizing a Novel Solvent-Free Pressure-Sensitive Adhesive (PSA): TEPI® Technology. J Pharm Innov 2018, 13 (1), 48–57.
5 Ganti, S. S.; Bhattaccharjee, S. A.; Murnane, K. S.; Blough, B. E.; Banga, A. K. Formulation and Evaluation of 4-Benzylpiperidine Drug-in-Adhesive Matrix Type Transdermal Patch. Int J Pharm 2018, 550 (1), 71–78.
6 Tyagi, S.; Goyal, K. Transdermal Drug Delivery System: Quality Approaches and Evaluation. Innov Int J Med Pharm Sci 2017, 2 (3), 15–21.
7 Krishna, M. K.; Nagaraju, T.; Gowthami, R.; Rajashekar, M.; Sandeep, S.; Himabindu, S.; Yamsani, S. K. Comprehensive Review on Buccal Delivery. Int J Pharm 2012, 2 (1), 205–217.
8 Liechty, W. B.; Kryscio, D. R.; Slaughter, B. V.; Peppas, N. A. Polymers for Drug Delivery Systems. Annu Rev Chem Biomol Eng 2010, 1, 149–173.
9 Aghabegi Moghanjoughi, A.; Khoshnevis, D.; Zarrabi, A. A Concise Review on Smart Polymers for Controlled Drug Release. Drug Deliv and Transl Res 2016, 6 (3), 333–340.
10 Kadajji, V. G.; Betageri, G. V. Water Soluble Polymers for Pharmaceutical Applications. Polymers 2011, 3 (4), 1972–2009.
11 Huichao, W.; Shouying, D.; Yang, L.; Ying, L.; Di, W. The Application of Biomedical Polymer Material Hydroxy Propyl Methyl Cellulose (HPMC) in Pharmaceutical Preparations. J Chem Pharm Res 2014, 6 (5), 6.
12 Akram, M. R.; Ahmad, M.; Abrar, A.; Sarfraz, R. M.; Mahmood, A. Formulation Design and Development of Matrix Diffusion Controlled Transdermal Drug Delivery of Glimepiride. Drug Des Devel Ther 2018, 12, 349–364.
13 Cherukuri, S.; Batchu, U. R.; Mandava, K.; Cherukuri, V.; Ganapuram, K. R. Formulation and Evaluation of Transdermal Drug Delivery of Topiramate. Int J Pharm Investig 2017, 7 (1), 10–17.
14 Patel, H.; Patel, U.; Bhimani, B.; Patel, G. Transdermal Drug Delivery System as Prominent Dosage Forms for the Highly Lipophilic Drugs. Int J Pharm Res Bio-Sci 2013, 1 (3), 42–65.
15 Yadav, V. K.; Gupta, A. B.; Kumar, R.; Yadav, J. S.; Kumar, B. Mucoadhesive Polymers: Means of Improving the Mucoadhesive Properties of Drug Delivery System. J Chem Pharm Res 2010, 2 (5), 418–432.
16 Yogananda, R.; Bulugondla, R. An Overview on Mucoadhesive Buccal Patches. Int J Univ Pharm and Life Sci 2012, 2 (2), 348–373.
17 Shabbir, M.; Ali, S.; Raza, M.; Sharif, A.; Akhtar, F. M.; Manan, A.; Fazli, A. R.; Younas, N.; Manzoor, I. Effect of Hydrophilic and Hydrophobic Polymer on in Vitro Dissolution and Permeation of Bisoprolol Fumarate through Transdermal Patch. Acta Pol Pharm 2017, 74 (1), 187–197.
18 Jhawat, V. C.; Saini, V.; Kamboj, S.; Maggon, N. Transdermal Drug Delivery Systems: Approaches and Advancements in Drug Absorption through Skin. Int J Pharm Sci Rev Res 2013, 20 (1), 47–56.
19 Bharkatiya, M.; Nema, R. K.; Bhatnagar, M. Designing and Characterization of Drug Free Patches for Transdermal Application. Int J Pharm Sci Drug Res 2010, 2 (1), 35–39.
20 Ramkanth, S.; Jayaprakash, S.; Vimalakannan, T. Formulation and Evaluation of a Monolithic Drug-in-Adhesive Type Patch Containing Tenoxicam. Int J Pharma Sci Res 2015, 6 (4), 654–659.
21 Prajapati, S. T.; Patel, C. G.; Patel, C. N. Formulation and Evaluation of Transdermal Patch of Repaglinide. ISRN Pharm 2011, 2011, 1–9.
22 Nayak, B. S.; Ellaiah, P.; Pattanayak, D.; Das, S. Formulation Design Preparation and in Vitro Characterization of Nebivolol Transdermal Patches. Asian J Pharm 2014, 5 (3), 175–182.
23 Shiyan, S.; Hertiani, T.; Martien, R.; Nugroho, A. K. Optimization and Validation of RP-HPLC/UV Detection for Several Compounds Simultaneously in Semi-Purified Extract of White Tea. Rasayan J Chem 2019, 12 (03), 1098–1109.
24 Pratiwi, G.; Martien, R.; Murwanti, R. Chitosan Nanoparticle as a Delivery System for Polyphenols from Meniran Extract (Phyllanthus Niruri L.): Formulation, Optimization, and Immunomodulatory Activity. Int J Appl Pharm 2019, 50–58.
25 Setyawan, E. I.; Setyowati, E. P.; Rohman, A.; Nugroho, A. K. Central Composite Design for Optimizing Extraction of EGCG from Green Tea Leaf (Camellia Sinensis L.). Int J Appl Pharm 2018, 10 (6), 211–216.
26 Supeni, G.; Cahyaningtyas, A. A.; Fitrina, A. Karakterisasi sifat fisik dan mekanik penambahan kitosan pada edible film karagenan dan tapioka termodifikasi. Jurnal Kimia dan Kemasan 2015, 37 (2), 103–110.
27 Gocho, H.; Shimizu, H.; Tanioka, A.; Chou, T.; Nakajima, T. Effect of Polymer Chain End on Sorption Isotherm of Water by Chitosan. Carbohydr Polym 2000, 41 (1), 87–90.
28 Shiyan, S.; Hertiani, T.; Martien, R.; Nugroho, A. K. Optimization of a Novel Kinetic-Assisted Infundation for Rich-EGCG and Polyphenols of White Tea (Camellia Sinensis) Using Central Composite Design. Int J Appl Pharm 2018, 10 (6), 259–267.
29 Chaudhary, A.; Nagaich, U.; Rastogi, B. Designing and Evaluation of Mucoadhesive Buccal Films of Propranolol Hydrochloride. J Adv Pharm Educ Res 2012, 2 (4), 239–246.
30 Loftsson, T.; Konrádsdóttir, F.; Másson, M. Influence of Aqueous Diffusion Layer on Passive Drug Diffusion from Aqueous Cyclodextrin Solutions through Biological Membranes. Pharmazie 2006, 61 (2), 83–89.
How to Cite
Pratiwi, G., Susanti, S., & Shiyan, S. (2021). Application of Factorial Design for Optimization of PVC-HPMC Polymers in Matrix Film Ibuprofen Patch-Transdermal Drug Delivery System. Indonesian Journal of Chemometrics and Pharmaceutical Analysis, 1(1), 11-21.
Original Articles