Recent Options for COVID-19 Treatment Conventional Therapy, Herbal Medicine, and Stem Cell-Based Therapies
Abstract
Several pharmacological therapies have been tried on COVID-19 patients. Nonetheless, there is still a significant practical and clinical gap. Treatment for COVID-19 is dominated by pharmacological treatment and is generally still based on empirical evidence. Common uses drugs in treating COVID-19 are histamine antagonists, antibiotics, antivirals, and several monoclonal antibody therapies. However, the mechanism of action of these drugs and concerns about long-term side effects are not yet specific. Therefore, this narrative review will discuss some of the efficacy and safety of some of the latest therapeutic options that may be potential candidates for COVID-19 therapy in the future, including herbal drug therapy and stem cells in in vitro, in vivo, and clinical studies. We use PubMed and ScienceDirect databases to search for studies, using the keywords “COVID-19” AND “Herbal Medicine” OR “Stem Cell Therapy” OR “recent therapy” AND “efficacy" OR “safety” to find relevant studies. Our review discusses clinical studies of efficacy, safety, and indications of some recent therapies. Our results indicate that the latest pharmacological therapies, herbal medicines, and stem cell therapy show high potential efficacy and safety in treating COVID-19 during active infection. In addition, it also has the potential to prevent post-infection multi-organ damage. Therefore, further and more in-depth studies are needed for several other therapeutic modalities not discussed in this review as candidates for compelling future COVID-19 therapy.
References
Ali MJ, Hanif M, Haider MA, Ahmed MU, Sundas F, Hirani A, Khan IA, Anis K, Karim AH. (2020). Treatment Options for COVID-19: A Review. Front Med (Lausanne). 7, 480. DOI: 10.3389/fmed.2020.00480. PMID: 32850922; PMCID: PMC7412857.
Alon R, Sportiello M, Kozlovski S, Kumar A, Reilly EC, Zarbock A, et al. (2021). Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19. Nat Rev Immunol. (1), 49–64.
An XD, Xu X, Xiao MZ, Min XJ, Lyu Y, Tian JX, et al. (2021). Efficacy of Jinhua Qinggan Granules Combined With Western Medicine in the Treatment of Confirmed and Suspected COVID-19: A Randomized Controlled Trial. Front Med. 8, 1–7.
Arabpour, E., Khoshdel, S., Tabatabaie, N., Akhgarzad, A., Zangiabadian, M., & Nasiri, M.J. (2021). Stem Cells Therapy for COVID-19: A Systematic Review and Meta-Analysis. Frontiers in Medicine, 8. https://doi.org/10.3389/fmed.2021.73759 0
Baig AM, Khaleeq A, Ali U, Syeda H. (2020). Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci, 11, 995–998. doi:10.1021/ acschemneuro.0c00122.
Balkrishna A, POKHREL S, Singh J, Varshney A. (2020). Withanone from Withania somnifera May Inhibit Novel Coronavirus (COVID-19) Entry by Disrupting Interactions between Viral S-Protein Receptor Binding Domain and Host ACE2 Receptor. Retrieved from: https://doi.org/10.21203/rs.3.rs-17806/v1
Borse S, Joshi M, Saggam A, Bhat V, Walia S, Marathe A, et al. (2021) Ayurveda botanicals in COVID-19 management: An in silico multi-target approach. PLoS ONE, 16(6). https://doi.org/10.1371/journal.pone.0248 479
Borujerdi, R., Adeli, S., Mohammadbeigi, A., Aliasl, F., Asghari, A., Hormati, A., Dehnavi, H., Hoseini, F., & Asghari, M. (2022). Effects of Iranian Polyherbal Syrup (Zufa syrup) on oxygen saturation and clinical symptoms in suspected patients with COVID-19: a triple-blinded, randomized, placebo-controlled trial. Medical Gas Research, 12(2), 44–50. https://doi.org/10.4103/2045-9912.32599 1
Cai Y, Zeng M, Chen YZ. (2021). The pharmacological mechanism of Huashi Baidu Formula for the treatment of COVID-19 by combined network pharmacology and molecular docking. Ann Palliat Med. 10(4), 3864–95.
Cao P, Wu S, Wu T, Deng Y, Zhang Q, Wang K. (2020). The important role of polysaccharides from a traditional Chinese medicine- Lung Cleansing and Detoxifying Decoction against the COVID-19 pandemic. Carbohydr Polym, 240, 116346.
Cha MH, Regueiro M, Sandhu DS. (2020). Gastrointestinal and hepatic manifestations of COVID-19: A comprehensive review. World J Gastroenterol, 26, 2323–2332. doi:10.3748/wjg.v26.i19.2323.
Chan JFW, Kok KH, Zhu Z, Chu H, To KKW, Yuan S, Yuen KY. (2020). Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect, 9, 221–236. doi.org/10.1080/22221751.2020.1 737364.
Chakraborty, R., & Parvez, S. (2020). COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials. Biochemical pharmacology, 180, 114184. https://doi.org/10.1016/j.bcp.2020.11418 4
Chien TJ, Liu CY, Chang YI, Fang CJ, Pai JH, Wu YX, et al. (2022). Therapeutic effects of herbal-medicine combined therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. 13, 1–17.
Chen, L., Qu, J., Kalyani, F. S., Zhang, Q., Fan, L., Fang, Y., Li, Y., & Xiang, C. (2022). Mesenchymal stem cell-based treatments for COVID-19: status and future perspectives for clinical applications. Cellular and molecular life sciences : CMLS, 79(3), 142. https://doi.org/10.1007/s00018-021-0409 6-y
Chen Y, Guo Y, Pan Y, Zhao ZJ. (2020) Structure analysis of the receptor binding of 2019-nCoV. Biochem Biophys Res Commun, 525: 135–140, doi:10.1016/j.bbrc.2020.02.071.
Chen IY, Moriyama M, Chang MF, Ichinohe T. (2019). Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome. Front Microbiol, 10, 50. doi:10.3389/fmicb.2019.00050.
Chen, Y., Liu, C., Wang, T., Qi, J., Jia, X., Zeng, X., Bai, J., Lu, W., Deng, Y., Zhong, B., & He, W. (2020). Efficacy and safety of Bufei Huoxue capsules in the management of convalescent patients with COVID-19 infection: A multicentre, double-blind, and randomized controlled trial. Journal of Ethnopharmacology, 284, 114830.
Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, Li J, Yao Y, Ge S, Xu G. (2020). Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int, 97, 829–838. doi:10.1016/j.kint.2020.03.005
Choudhery, M. S., & Harris, D. T. (2020). Stem cell therapy for COVID-19: Possibilities and challenges. Cell Biologi International, 44(11),2182–2191. https://doi.org/10.1002/cbin.11440
Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E. (2020). The spike glycoprotein of the new coronavirus 2019-nCoV contains a furinlike cleavage site absent in CoV of the same clade. Antiviral Res, 176, 104742, doi:10.1016/j.antiviral.2020.104742.
Chopra, A., Srikanth, N., & Patwardhan, B. (2020). Withania somnifera as a safer option to hydroxychloroquine in the chemoprophylaxis of COVID-19: Results of interim analysis. Complementary Therapies in Medicine, 62, 102768.
Duan ZP, Jia ZH, Zhang J, Liu S, Chen Y, Liang LC, et al. (2011). Natural herbal medicine lianhuaqingwen capsule anti-influenza a (H1N1) trial: A randomized, double blind, positive controlled clinical trial. Chin Med J (Engl). 124(18), 2925–33.
Enmozhi, S. K., Raja, K., Sebastine, I., & Joseph, J. (2021). Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach. Journal of biomolecular structure & dynamics, 39(9), 3092–3098. https://doi.org/10.1080/07391102.2020.1 760136
Forte, G. C., da Silva, D. T. R., Hennemann, M. L., Sarmento, R. A., Almeida, J. C., & de Tarso Roth Dalcin, P. (2018). Diet effects in the asthma treatment: A systematic review. Critical Reviews in Food Science and Nutrition, 58(11), 1878–1887. https://doi.org/10.1080/10408398.2017.1 289893
Gennaro, F. Di, Pizzol, D., Marotta, C., Antunes, M.,Racalbuto, V., Veronese, N., & Smith, L. (2020). Coronavirus Diseases ( COVID-19 ) Current Status and Future Perspectives : A Narrative Review. International Journal of Environmental Research and Public HealthEnvironmental Research and Public Health, 17(2690), 1–11.
Gheware, A., Dholakia, D., Kannan, S. (2021). Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions. Respir Res 22, 99 https://doi.org/10.1186/s12931-021-0169 8-9
Guo, H., Zheng, J., Huang, G., Xiang, Y., Lang, C., Li, B., Huang, D., Sun, Q., Luo, Y., Zhang, Y., Huang, L., Fang, W., Zheng, Y., & Wan, S. (2020). Xuebijing injection in the treatment of COVID-19: A retrospective case-control study. Annals of Palliative Medicine, 9(5), 3235–3248. https://doi.org/10.21037/apm-20-1478
Gurung, A. B., Ali, M. A., Lee, J., Abul Farah, M., dan Al-Anazi, K. M, (2020). 'In silico screening of FDA approved drugs reveals ergotamine and dihydroergotamine as potential coronavirus main protease enzyme inhibitors', Saudi Journal of Biological Sciences, vol 27(10), pp2674-2682. https://doi.org/10.1016/j.sjbs.2020.06.005
Girija, P. L. T., & Sivan, N. (2022). Ayurvedic treatment of COVID-19/SARS-CoV-2: A case report. Journal of Ayurveda and Integrative Medicine, 13(1), 100329. https://doi.org/10.1016/j.jaim.2020.06.00 1
Havranek, B., dan Islam, S. M, (2021). 'An in silico approach for identification of novel inhibitors as potential therapeutics targeting COVID-19 main protease', Journal of Biomolecular Structure and Dynamics, 39(12), pp4304-4315. https://doi.org/10.1080/07391102.2020.1 776158
Hamed Valizadeha, Abdolmohammadi-vahid, S., Danshinae, S., Gencerf, M. Z., Ammarig, A., Sadeghia, A., Roshangard, L., Aslanih, S., Esmaeilzadehi, A., Ghaebii, M., Valizadehb, S., & Ahmadid, M. (2020). Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients. Diabetes Metab Syndr., 14(4), 337–339.
Hertanto, D. M., Wiratama, B. S., Sutanto, H., & Wungu, C. D. K. (2021). Immunomodulation as a Potent COVID-19 Pharmacotherapy: Past, Present and Future. Journal of inflammation research, 14, 3419–3428. https://doi.org/10.2147/JIR.S322831
Huang, K., Zhang, P., Zhang, Z., Youn, J. Y., Wang, C., Zhang, H., et al. (2021). Traditional Chinese Medicine (TCM) in the Treatment of COVID-19 and Other Viral Infections: Efficacies and Mechanisms. Pharmacol. Ther., 225, 107843. doi:10.1016/j.pharmthera.2021.107843.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395, 497–506, doi:10.1016/S0140-6736(20)30183-5.
Hu, G. M., He, C. X., Sun, Q. L., Wan, B. B., Li, Y. B., and Gao, J. Y. (2020). Preliminary Study on Clinical Efficacy of “Qingfei Paidu Granule” in Treating Coronavirus Disease 2019. Tianjin J. Tradit. Chin. Med., 37 (9), 999–1004.
Hu, B., Huang, S., & Yin, L. (2021). The cytokine storm and COVID-19. In Journal of Medical Virology, 93(1), 250–256. https://doi.org/10.1002/jmv.26232
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N. H., Nitsche, A., Müller, M. A., Drosten, C., & Pöhlmann, S. (2020). SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181(2), 271–280.e8. https://doi.org/10.1016/j.cell.2020.02.052
Izcovich, A., Siemieniuk, R. A., Bartoszko, J. J., Ge, L., Zeraatkar, D., Kum, E., Qasim, A., Khamis, A. M., Rochwerg, B., Agoritsas, T., Chu, D. K., McLeod, S. L., Mustafa, R. A., Vandvik, P., dan Brignardello-Petersen, R, (2022). Adverse effects of remdesivir, hydroxychloroquine and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomised trials, BMJ open, 12(3). https://doi.org/10.1136/bmjopen-2020-04 8502
Islam, M. N., Hossain, K. S., Sarker, P. P., Ferdous, J., Hannan, M. A., Rahman, M. M., Chu, D. T., & Uddin, M. J. (2021). Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure. Phytotherapy Research, 35(3), 1329–1344. https://doi.org/10.1002/ptr.6895
Jain J, Kumar A, Narayanan V, Ramaswamy RS, Sathiyarajeswaran P, Shree Devi MS, et al. (2020). Antiviral activity of ethanolic extract of Nilavembu Kudineer against dengue and chikungunya virus through in vitro evaluation. J Ayurveda Integr Med., 11(3), 329–35. https://doi.org/10.1016/j.jaim.2018.05.00 6
Jamshidi E, Babajani A, Soltani P, Niknejad H. (2021). Proposed Mechanisms of Targeting COVID-19 by Delivering Mesenchymal Stem Cells and Their Exosomes to Damaged Organs. Stem Cell Rev Reports, 17(1), 176–92.
Jean, S. S., Lee, P. I., & Hsueh, P. R. (2020). Treatment options for COVID-19: The reality and challenges. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 53(3), 436–443. https://doi.org/10.1016/j.jmii.2020.03.034
Kageyama, Y., Aida, K., Kawauchi, K., Morimoto, M., Ebisui, T., Akiyama, T., dan Nakamura, T. (2021). Jinhua Qinggan granule, a Chinese herbal medicine against COVID-19, induces rapid changes in the neutrophil/lymphocyte ratio and plasma levels of IL-6 and IFN-γ: An open-label, single-arm pilot study. World Academy of Sciences Journal., 4(1), 1-8. https://doi.org/10.3892/wasj.2021.137.
Kumar, D., Kumar, A., Kumar, V., Poyoja, R., dan Ghosh, A, (2021). Agra: An Old Cluster Facing the New Competition, Environmental Pollution Journal, 274, 1-10. https://www.sciencedirect.com/science/ar ticle/abs/pii/S0305750X99000704
Karimi, M., Zarei, A., Soleymani, S., Jamalimoghadamsiahkali, S., Asadi, A., Shati, M., Jafari, M., Rezadoost, H., Kordafshar, G., Naghizadeh, A., Mardi, R., Namiranian, P., Khamechi, S. P., Ansari, N., Adel Mehraban, M. S., Aliakbarzadeh, H., Khanavi, M., Esmaealzadeh, N., Moravveji, A., … Zargaran, A. (2021). Efficacy of Persian medicine herbal formulations (capsules and decoction) compared to standard care in patients with COVID-19, a multicenter open-labeled, randomized, controlled clinical trial. Phytotherapy Research, 35(11), 6295–6309. https://doi.org/10.1002/ptr.7277.
Koshak, A. E., Koshak, E. A., Mobeireek, A. F., & Badawi, M. A. (2020). Nigella sativa for the treatment of COVID-19: An open-label randomized controlled clinical trial. Complementary Therapies in Medicine, 61, 102769.
Kosari, M., Noureddini, M., Khamechi, S. P., Najafi, A., Ghaderi, A., Sehat, M., & Banafshe, H. R. (2021). The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID-19: A clinical trial. Phytotherapy Research, 35(7), 4000–4006. https://doi.org/10.1002/ptr.7116
Lauring, A. S., dan Malani, P. N, (2021). Variants of SARS-CoV-2. AMA - Journal of the American Medical Association, 326(9), 880. https://doi.org/10.1001/jama.2021.14181
Lazzaroni, M. G., Piantoni, S., Masneri, S., Garrafa, E., Martini, G., Tincani, A., Andreoli, L., & Franceschini, F. (2021). Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system. Blood reviews, 46, 100745. https://doi.org/10.1016/j.blre.2020.100745
Letko, M., Marzi, A., & Munster, V. (2020). Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nature microbiology, 5(4), 562–569. https://doi.org/10.1038/s41564-020-0688-y
Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, Dequanter D, Blecic S, El Afia F, Distinguin L, Chekkoury-Idrissi Y, Hans S, Delgado IL, Calvo-Henriquez C, Lavigne P, Falanga C, Barillari MR, Cammaroto G, Khalife M, Leich P, Souchay C, Rossi C, Journe F, Hsieh J, Edjlali M, Carlier R, Ris L, Lovato A, De Filippis C, Coppee F, Fakhry N, Ayad T, Saussez S. (2020). Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol, 277, 2251–2261, doi:10.1007/s00405- 020-05965-1.
Li C, Li Y, Zhang H, Zhuo Y, Zhang L, Yang L, et al. (2023). Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway. Phytomedicine, 109, 154551. https://doi.org/10.1016/j.phymed.2022.15 4551
Li, Q., Wang, H., Li, X., Zheng, Y., Wei, Y., Zhang, P., et al. (2020). The Role Played by Traditional Chinese Medicine in Preventing and Treating COVID-19 in China. Front. Med., 14 (5), 681–688. doi:10.1007/s11684-020-0801-x
Li, Y., Yu, W., Zhai, J., Wang, K., Huo, H., & Du, Z. (2022). The efficacy of combined therapy of qingfeiPaidu capsule and lianhuaqingwen capsule nursing interventions for hospitalized patients with COVID-19: A retrospective study of medical records. Medicine (United States), 101(32), E29964. https://doi.org/10.1097/MD.00000000000 29964
Liu, Z., Li, X., Gou, C., Li, L., Luo, X., Zhang, C., et al. (2020). Effect of Jinhua Qinggan Granules on Novel Coronavirus Pneumonia in Patients. J. Tradit Chin. Med., 40 (3), 467–472. doi:10.19852/j.cnki.jtcm.2020.03.016
Li, G. Q., Zhao, J., Tu, Z. T., Li, J. B., Liu, Q. Q., Shi, L. Q., Miao, Q., Yuan, H. Q., Liu, X. Q., Long, Y. Y., Liu, Z. G., Zhao, T., Li, L., Tant, Q. H., He, Y. C., Bian, Y. J., & Hu, J. Q. (2013). Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 33(12), 1631–1635.
Li, L. C., Zhang, Z. H., Zhou, W. C., Chen, J., Jin, H. Q., Fang, H. M., Chen, Q., Jin, Y. C., Qu, J., & Kan, L. D. (2020). Lianhua Qingwen prescription for Coronavirus disease 2019 (COVID-19) treatment: Advances and prospects. Biomedicine & pharmacotherapy, 130, 110641. https://doi.org/10.1016/j.biopha.2020.110641
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N. (2020). Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med, 382, 1199–207.
Li Y, Chang N, Han Y, Zhou M, Gao J, Hou Y, et al. (2017). Anti-inflammatory effects of Shufengjiedu capsule for upper respiratory infection via the ERK pathway. Biomed Pharmacother, 94, 758–66. http://dx.doi.org/10.1016/j.biopha.2017.0 7.118
Li Y, Li B, Wang P, Wang Q. (2021). Traditional Chinese Medicine, Qingfei Paidu Decoction and Xuanfei Baidu Decoction, Inhibited Cytokine Production via NF-κB Signaling Pathway in Macrophages: Implications for Coronavirus Disease 2019 (COVID-19) Therapy. Front Pharmacol, 12, 1–10.
Liang S, Fang M, Liang C, Lan H, Shen C, Yan L. (2021). Therapeutic effects and safety of oral Chinese patent medicine for COVID-19: A rapid systematic review and meta-analysis of randomized controlled trials. Complement Ther Med, 60, 102744.
Lin, Y., Cai, C. Z., Alias, H., Wong, L. P., & Hu, Z. (2022). A cross-sectional survey of self-medication with Traditional Chinese Medicine for treatment and prevention of COVID-19. Complementary therapies in medicine, 71, 102898. https://doi.org/10.1016/j.ctim.2022.102898
Liu, C. xiao, (2021). Overview on development of ASEAN traditional and herbal medicines, Chinese Herbal Medicines, 13(4), 441- 450. https://doi.org/10.1016/j.chmed.2021.09.0 02
Liang, C., Hui, N., Liu, Y., Qiao, G., Li, J., Tian, L., Ju, X., Jia, M., Liu, H., Cao, W., Yu, P., Li, H., & Ren, X. (2021). Insights into forsythia honeysuckle (Lianhuaqingwen) capsules: A Chinese herbal medicine repurposed for COVID-19 pandemic. Phytomedicine plus : international journal of phytotherapy and phytopharmacology, 1(2), 100027. https://doi.org/10.1016/j.phyplu.2021.100027
Liu, X., Qu, X., Chen, Y., Liao, L., Cheng, K., Shao, C., Zenke, M., Keating, A., & Zhao, R. C. H. (2012). Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IL-10–Dependent Regulatory Dendritic Cells by SOCS3 Activation. The Journal of Immunology, 189(3), 1182–1192. https://doi.org/10.4049/jimmunol.110299 6
Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet, 2020,395-565.
Luo, W., Ding, R., Guo, X., Zhan, T., Tang, T., & Fan, R. (2020). Clinical data mining reveals Gancao-Banxia as a potential herbal pair against moderate COVID-19 by dual binding to IL-6/STAT3. Computers in Biology and Medicine, 145, 105457.
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., Miao, X., Li, Y., & Hu, B. (2020). Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA neurology, 77(6), 683–690. https://doi.org/10.1001/jamaneurol.2020.1127
Mahaboob Ali, A. A., Bugarcic, A., Naumovski, N., & Ghildyal, R. (2022). Ayurvedic formulations: Potential COVID-19 therapeutics? Phytomedicine Plus, 2(3), 100286. https://doi.org/10.1016/j.phyplu.2022.100 286
Marinosci A, Landis BN, Calmy A. (2020). Possible link between anosmia and COVID-19: sniffing out the truth. Eur Arch Otorhinolaryngol, 277, 2149– 2150, doi:10.1007/s00405-020-05966-0.
Maurya, D. K., & Sharma, D. (2022). Evaluation of traditional ayurvedic Kadha for prevention and management of the novel Coronavirus (SARS-CoV-2) using in silico approach. Journal of biomolecular structure & dynamics, 40(9), 3949–3964. https://doi.org/10.1080/07391102.2020.1852119
Maurya, V. K., Kumar, S., Bhatt, M. L. B., & Saxena, S. K. (2022). Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection. Journal of biomolecular structure & dynamics, 40(4), 1719–1735. https://doi.org/10.1080/07391102.2020.1832577
Mezey, É., & Nemeth, K. (2015). Mesenchymal stem cells and infectious diseases: Smarter than drugs. Immunology Letters, 168(2), 208–214. https://doi.org/10.1016/j.imlet.2015.05.02 0
Munir, H., & McGettrick, H. M. (2016). Mesenchymal stem cells therapy for autoimmune disease: risks and rewards. Stem Cells and Development, 44(0), 1–25.
Mosadegh, M., Khalkhali, A., Erfani, Y., & Nezamdoost, M. (2020). The effect of Nutrition Bio-shield superfood (NBS) on disease severity and laboratory biomarkers in patients with COVID-19: A randomized clinical trial. Microbial Pathogenesis, 172, 105792.
Natarajan S, Anbarasi C, Sathiyarajeswaran P, Manickam P, Geetha S, Kathiravan R, et al. (2021). Kabasura Kudineer (KSK), a poly-herbal Siddha medicine, reduced SARS-CoV-2 viral load in asymptomatic COVID-19 individuals as compared to vitamin C and zinc supplementation: findings from a prospective, exploratory, open-labeled, comparative, randomized c. Trials, 22(1), 1–11.
Nesari, T., Kadam, S., Vyas, M., Huddar, V. G., Prajapati, P. K., Rajagopala, M., More, A., Rajagopala, S. K., Bhatted, S. K., Yadav, R. K., Mahanta, V., Mandal, S. K., Mahto, R. R., Kajaria, D., Sherkhane, R., Bavalatti, N., Kundal, P., Dharmarajan, P., Bhojani, M., Bhide, B., … Tripathi, R. (2022). AYURAKSHA, a prophylactic Ayurvedic immunity boosting kit reducing positivity percentage of IgG COVID-19 among frontline Indian Delhi police personnel: A non-randomized controlled intervention trial. Frontiers in public health, 10, 920126. https://doi.org/10.3389/fpubh.2022.920126
Niazkar, H. R., Zibaee, B., Nasimi, A., & Bahri, N. (2020). The neurological manifestations of COVID-19: a review article. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 41(7), 1667–1671. https://doi.org/10.1007/s10072-020-04486-3
Oriol, M., Marc, C.-M., & Maria, U. (2020). Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized- Controlled Trial. Clin Infect Dis, 54(650), 1–54.
Panda, A. K., Kar, S., Rai, A. K., Rao, B. C. S., & Srikanth, N. (2022). AYUSH- 64: A potential therapeutic agent in COVID-19. Journal of Ayurveda and integrative medicine, 13(2), 100538. https://doi.org/10.1016/j.jaim.2021.100538
Parameswaran, S., Ramulu, S. D. M. S., Arivarasan, V. K., Kadarkarai, K., Dhanakoti, R. K., & Loganathan, K. (2021). Evaluation of in-vitro immunomodulatory activity and thrombolytic potential of kabasura kudineer (Ksk): An official siddha polyherbal formulation. Indian Journal of Pharmaceutical Education and Research, 55(3), 774–781. https://doi.org/10.5530/ijper.55.3.150
Pan, X., Dong, L., Yang, L., Chen, D., and Peng, C. (2020). Potential Drugs for the Treatment of the Novel Coronavirus Pneumonia (COVID-19) in China. Virus. Res, 286, 198057. doi:10.1016/j.virusres.2020.198057
Paudyal, V., Sun, S., Hussain, R., Abutaleb, M. H., dan Wesley, E, (2020). Complementary and alternative medicines use in COVID-19: A global perspective on practice, policy and research, Research in Social and Administrative Pharmacy, 18, 2524-2528.
Perazzolo, S., Zhu, L., Lin, W., Nguyen, A., & Ho, R. J. Y. (2021). Systems and Clinical Pharmacology of COVID-19 Therapeutic Candidates: A Clinical and Translational Medicine Perspective. Journal of Pharmaceutical Sciences, 110(3), 1002–1017. https://doi.org/10.1016/j.xphs.2020.11.01 9.
Polansky, H. (2020). Coronavirus disease 2019 (COVID-19): first indication of efficacy of Gene-Eden-VIR/Novirin in SARS-CoV-2 infection. International Journal of Antimicrobial Agents, 55, 1–2.
Qu, W., Wang, Z., Hare, J. M., Bu, G., Mallea, J. M., Pascual, J. M., Caplan, A. I., Kurtzberg, J., Zubair, A. C., Kubrova, E., Engelberg-Cook, E., Nayfeh, T., Shah, V. P., Hill, J. C., Wolf, M. E., Prokop, L. J., Murad, M. H., & Sanfilippo, F. P. (2020). Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome. Stem cells translational medicine, 9(9), 1007–1022. https://doi.org/10.1002/sctm.20-0146
Ramazani, R., Ramazani, S., & Hosseinabadi, T. (2020). Efficacy of a multiple-indication antiviral herbal drug (Saliravira®) for COVID-19 outpatients: A pre-clinical and randomized clinical trial study. Biomedicine & Pharmacotherapy, 149, 112729.
Rahaman, A., Zeng, X. A., Kumari, A., Rafiq, M., Siddeeg, A., Manzoor, M. F., et al. (2019). Influence of Ultrasound-Assisted Osmotic Dehydration on Texture, Bioactive Compounds and Metabolites Analysis of Plum. Ultrason. Sonochem. 58, 104643. doi:10.1016/j.ultsonch.2019.104643
Rastogi, S., Pandey, D. N., & Singh, R. H. (2022). COVID-19 pandemic: A pragmatic plan for ayurveda intervention. Journal of Ayurveda and integrative medicine, 13(1), 100312. https://doi.org/10.1016/j.jaim.2020.04.002
Reddy, R. G., Gosavi, R. V., Yadav, B., Rai, A. K., Holay, M. P., Talekar, M., Jameela, S., Sharma, B. S., Khanduri, S., Rana, R., Tripathi, A., Chandrasekhararao, B., Srikanth, N., & Dhiman, K. S. (2020). AYUSH-64 as an add-on to standard care in asymptomatic and mild cases of COVID-19: A randomized controlled trial. Ayu, 41(2), 107–116. https://doi.org/10.4103/ayu.ayu_14_21
Rizk, J. G., Kalantar-Zadeh, K., Mehra, M. R., Lavie, C. J., Rizk, Y., & Forthal, D. N. (2020). Pharmaco-Immunomodulatory Therapy in COVID-19. Drugs, 80(13), 1267–1292. https://doi.org/10.1007/s40265-020-0136 7-z
Rommasi, F., Nasiri, M. J., & Mirsaeidi, M. (2022). Immunomodulatory agents for COVID-19 treatment: possible mechanism of action and immunopathology features. Molecular and cellular biochemistry, 477(3), 711–726. https://doi.org/10.1007/s11010-021-0432 5-9
Robles-Escajeda, E., Lerma, D., Nyakeriga, A. M., Ross, J. A., Kirken, R. A., Aguilera, R. J., & Varela-Ramirez, A. (2013). Searching in Mother Nature for Anti-Cancer Activity: Anti-Proliferative and Pro-Apoptotic Effect Elicited by Green Barley on Leukemia/Lymphoma Cells. PLoS ONE, 8(9),118.https://doi.org/10.1371/journal.pone.0073 508
Rostami, M.,Hassan, M. (2020). D-Dimer Level in COVID-19 Infection: A Systematic Review. Expert Rev. Hematol. 13 (11), 1265–1275. doi: 10.1080/ 17474086.2020.1831383
Sasidharan, S., Nair J, H., K P, S., Paul, J., R, M. K., Rajendran, K., Saibannavar, A. A., & Nirali, S. (2022). An efficacy and safety report based on randomized controlled single-blinded multi-centre clinical trial of ZingiVir-H, a novel herbo-mineral formulation designed as an add-on therapy in adult patients with mild to moderate COVID-19. PloS one, 17(12), e0276773. https://doi.org/10.1371/journal.pone.0276773
Sharma, V., Krushna, B., Soneja, M., & Huddar, V. G. (2020). Efficacy of add-on Ayurveda and Yoga intervention in health care workers of tertiary care hospital during COVID-19: Randomized controlled trial. Complementary Therapies in Clinical Practice, 48, 101601.
Shi, N., Liu, B., Liang, N., Ma, Y., Ge, Y., Yi, H., Wo, H., Gu, H., Kuang, Y., Tang, S., Zhao, Y., Tong, L., Liu, S., Zhao, C., Chen, R., Bai, W., Fan, Y., Shi, Z., Li, L., Liu, J., … Wang, Y. (2020). Association between early treatment with Qingfei Paidu decoction and favorable clinical outcomes in patients with COVID-19: A retrospective multicenter cohort study. Pharmacological research, 161, 105290. https://doi.org/10.1016/j.phrs.2020.105290
Shi, N., Guo, L., Liu, B., Bian, Y., Chen, R., Chen, S., et al. (2021). Efficacy and Safety of Chinese Herbal Medicine versus Lopinavir-Ritonavir in Adult Patients with Coronavirus Disease 2019: A Non-randomized Controlled Trial. Phytomedicine, 81, 153367. doi:10.1016/j.phymed.2020.153367
Schnappauf, O., Chae, J. J., Kastner, D. L., & Aksentijevich, I. (2019). The Pyrin Inflammasome in Health and Disease. Frontiers in immunology, 10, 1745. https://doi.org/10.3389/fimmu.2019.01745
Shah, M. R., Fatima, S., Khan, S. N., Ullah, S., Himani, G., Wan, K., Lin, T., Lau, J. Y. N., Liu, Q., & Lam, D. S. C. (2022). Jinhua Qinggan granules for non-hospitalized COVID-19 patients: A double-blind, placebo-controlled, and randomized controlled trial. Frontiers in medicine, 9, 928468. https://doi.org/10.3389/fmed.2022.928468
Shen, X., & Yin, F. (2021). The mechanisms and clinical application of Traditional Chinese Medicine Lianhua-Qingwen capsule. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 142, 111998. https://doi.org/10.1016/j.biopha.2021.111998
Şimşek-Yavuz, S., & Komsuoğlu Çelikyurt, F. I. (2021). An update of anti-viral treatment of COVID-19. Turkish journal of medical sciences, 51(SI-1), 3372–3390. https://doi.org/10.3906/sag-2106-250
Shirkande, A. (2022). Ayurvedic evaluation and treatment of Covid 19: A case report. Journal of Ayurveda and integrative medicine, 13(1), 100489. https://doi.org/10.1016/j.jaim.2021.07.00 5
Skipper, C. P., Pastick, K. A., Engen, N. W., Bangdiwala, A. S., Abassi, M., Lofgren, S. M., Williams, D. A., Okafor, E. C., Pullen, M. F., Nicol, M. R., Nascene, A. A., Hullsiek, K. H., Cheng, M. P., Luke, D., Lother, S. A., MacKenzie, L. J., Drobot, G., Kelly, L. E., Schwartz, I. S., … Boulware, D. R. (2020). Hydroxychloroquine in nonhospitalized adults with early covid-19: A randomized trial. Annals of Internal Medicine, 173(8), 623–631. https://doi.org/10.7326/M20-4207
Soy, M., Keser, G., Atagündüz, P., Tabak, F., Atagündüz, I., dan Kayhan, S, (2020). Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment, Clinical Rheumatology, 39(7), 2085-2094. https://doi.org/10.1007/s10067-020-0519 0-5 .
Srivastava, A., Rengaraju, M., Srivastava, S., Narayanan, V., Gupta, V., Upadhayay, R., Kumar, J., Parameswaran, S., KanakavalliKadarkarai, & AarthiVelmurugan (2021). Efficacy of two siddha polyherbal decoctions, Nilavembu Kudineer and Kaba Sura Kudineer, along with standard allopathy treatment in the management of mild to moderate symptomatic COVID-19 patients-a double-blind, placebo-controlled, clinical trial. Trials, 22(1), 570. https://doi.org/10.1186/s13063-021-05478-0
Tao, Z., Gao, J., Zhang, G., Xue, M., Yang, W., Tong, C., & Yuan, Y. (2014). Shufeng Jiedu Capsule protect against acute lung injury by suppressing the MAPK/NF-κB pathway. Bioscience trends, 8(1), 45–51. https://doi.org/10.5582/bst.8.45
Thakar, A., Goyal, M., Bhinde, S., Chhotala, Y., Panara, K., & Chaudhari, S. (2022). Impact of AYUSH 64 as an adjunctive to standard of care in mild COVID 19 - An open-label randomized controlled pilot study. Journal of Ayurveda and integrative medicine, 13(3), 100587. https://doi.org/10.1016/j.jaim.2022.100587
Tian, H., Liu, Z., Pu, Y., & Bao, Y. (2019). Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4/TRAF6/NF-κB signaling in vitro and in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 112, 108709. https://doi.org/10.1016/j.biopha.2019.108709
Tay, M. Z., Poh, C. M., Rénia, L., MacAry, P. A., & Ng, L. F. P. (2020). The trinity of COVID-19: immunity, inflammation and intervention. Nature reviews. Immunology, 20(6), 363–374. https://doi.org/10.1038/s41577-020-0311-8
Tavakoli, A., Molavi Vardanjani, H., Namjouyan, F., Cramer, H., & Pasalar, M. (2022). Efficacy of Persian barley water on clinical outcomes of hospitalized moderate-severity COVID-19 patients: A single-blind, add-on therapy, randomized controlled clinical trial. European Review for Medical and Pharmacological Sciences, 26(3), 1033–1041. https://doi.org/10.26355/eurrev_202202_ 28013
Tong, T., Wu, Y. Q., Ni, W. J., Shen, A. Z., & Liu, S. (2020). The potential insights of Traditional Chinese Medicine on treatment of COVID-19. Chinese Medicine (United Kingdom), 15(1), 1–6. https://doi.org/10.1186/s13020-020-0032 6-w
Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, Franciotta D, Baldanti F, Daturi R, Postorino P, Cavallini A, Micieli G. (2020). Guillain- Barré Syndrome associated with SARSCoV-2. N Engl J Med 382: 2574–2576 doi:10.1056/NEJMc2009191.
Vaira, L. A., Salzano, G., Fois, A. G., Piombino, P., & De Riu, G. (2020). Potential pathogenesis of ageusia and anosmia in COVID-19 patients. International forum of allergy & rhinology, 10(9), 1103–1104. https://doi.org/10.1002/alr.22593
Wang, Y., Jin, X., Fan, Q., Li, C., Zhang, M., Wang, Y., Wu, Q., Li, J., Liu, X., Wang, S., Wang, Y., Li, L., Ling, J., Li, C., Wang, Q., & Liu, Y. (2022). Deciphering the Active Compounds and Mechanisms of HSBDF for Treating ALI via Integrating Chemical Bioinformatics Analysis. Frontiers in pharmacology, 13, 879268. https://doi.org/10.3389/fphar.2022.879268
Wang, M., Yuan, Q., & Xie, L. (2018). Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application. Stem cells international, 2018, 3057624. https://doi.org/10.1155/2018/3057624
Wang, Q., Zhu, H., Li, M., Liu, Y., Lai, H., Yang, Q., Cao, X., dan Ge, L. (2021). Efficacy and Safety of Qingfe Paidu Decoction for COVID-19: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology, 12, 1-11. https://doi.org/10.3389/fphar.2021.68885 7
Wan, Y., Shang, J., Graham, R., Baric, R. S., & Li, F. (2020). Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. Journal of virology, 94(7), e00127-20. https://doi.org/10.1128/JVI.00127-20
WHO Solidarity Trial Consortium, Pan, H., Peto, R., Henao-Restrepo, A. M., Preziosi, M. P., Sathiyamoorthy, V., Abdool Karim, Q., Alejandria, M. M., Hernández García, C., Kieny, M. P., Malekzadeh, R., Murthy, S., Reddy, K. S., Roses Periago, M., Abi Hanna, P., Ader, F., Al-Bader, A. M., Alhasawi, A., Allum, E., Alotaibi, A., … Swaminathan, S. (2021). Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results. The New England journal of medicine, 384(6), 497–511. https://doi.org/10.1056/NEJMoa2023184
Xia, K. Y., Zhao, Z., Shah, T., Wang, J. Y., & Baloch, Z. (2022). Composition, Clinical Efficiency, and Mechanism of NHC-Approved "Three Chinese Medicines and Three Chinese Recipes" for COVID-19 Treatment. Frontiers in pharmacology, 12, 781090. https://doi.org/10.3389/fphar.2021.781090
Xia, Q. D., Xun, Y., Lu, J. L., Lu, Y. C., Yang, Y. Y., Zhou, P., Hu, J., Li, C., & Wang, S. G. (2020). Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19. Cell proliferation, 53(12), e12949. https://doi.org/10.1111/cpr.12949
Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H. (2020). Evidence for gastrointestinal infection of SARSCoV-2. Gastroenterology, 158, 1831–1833.e3, doi:10.1053/j.gastro.2020.02.055
Xiao, M., Tian, J., Zhou, Y., Xu, X., Min, X., Lv, Y., et al. (2020). Efficacy of Huoxiang Zhengqi Dropping Pills and Lianhua Qingwen Granules in Treatment of COVID-19: A Randomized Controlled Trial. Pharmacol. Res. 161, 105126. doi:10.1016/j.phrs.2020.105126
Xiong, J., Bao, L., Qi, H., Feng, Z., & Shi, Y. (2020). Mesenchymal Stem Cell-Based Therapy for COVID-19: Possibility and Potential. Current Stem Cell Research & Therapy, 16(2), 105–108. doi:10.2174/1574888x156662006011528 32
Xin, S., Cheng, X., Zhu, B., Liao, X., Yang, F., Song, L., Shi, Y., Guan, X., Su, R., Wang, J., Xing, L., Xu, X., Jin, L., Liu, Y., Zhou, W., Zhang, D., Liang, L., Yu, Y., & Yu, R. (2020). Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment. Biomedicine & pharmacotherapy, 129, 110500. https://doi.org/10.1016/j.biopha.2020.110500
Xu, F., Hou, T., Shen, A., Jin, H., Xiao, Y., Yu, W., Li, X., Wang, J., Liu, Y., & Liang, X. (2021). Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays. Journal of ethnopharmacology, 280, 114488. https://doi.org/10.1016/j.jep.2021.114488
Xu X, Chen P, Wang J, Feng J, Zhou H, Li X, Zhong W, Hao P. (2020). Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci, 63, 457–460, doi:10.1007/s11427-020-1637-5.
Xu, Y., Yang, L., Wang, L., & Chen, F. (2022). Potential therapeutic effect of Shufeng Jiedu capsule and its major herbs on coronavirus disease 2019 (COVID-19): A review. Drug discoveries & therapeutics, 15(6), 289–299. https://doi.org/10.5582/ddt.2021.01099
Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., Tai, Y., Bai, C., Gao, T., Song, J., Xia, P., Dong, J., Zhao, J., & Wang, F. S. (2020). Pathological findings of COVID-19 associated with acute respiratory distress syndrome. The Lancet. Respiratory medicine, 8(4), 420–422. https://doi.org/10.1016/S2213-2600(20)30076-X
Yang, R., Liu, H., Bai, C., Wang, Y., Zhang, X., Guo, R., Wu, S., Wang, J., Leung, E., Chang, H., Li, P., Liu, T., & Wang, Y. (2020). Chemical composition and pharmacological mechanism of Qingfei Paidu Decoction and Ma Xing Shi Gan Decoction against Coronavirus Disease 2019 (COVID-19): In silico and experimental study. Pharmacological research, 157, 104820. https://doi.org/10.1016/j.phrs.2020.104820
Ye Q, Wang B, Mao J. (2020). The pathogenesis and treatment of the ‘cytokine storm’ in COVID-19. J Infect, 80, 607–613, doi:10.1016/j.jinf.2020.03.037.
Yu, Ping; Li, Ye-Zi; Wan, Shao-Bing; Wang, Ying. (2020). Effects of Lianhua Qingwen Granules Plus Arbidol on Treatment of Mild Corona Virus Disease-19. Chin. Pharm. J. (China), 12(55), 1042-1045
Yong-Li, W., Cong-Cong, Z., Feng, Z., Jian, H., Dan-Dan, W., Yong-Fang, Z., Wei, L., Guang-Bo, G. E., & Jian-Guang, X. U. (2020). Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 45(22), 5537–5554. https://doi.org/10.19540/j.cnki.cjcmm.202 00903.201
Zeng, J. H., Liu, Y. X., Yuan, J., Wang, F. X., Wu, W. B., Li, J. X., Wang, L. F., Gao, H., Wang, Y., Dong, C. F., Li, Y. J., Xie, X. J., Feng, C., & Liu, L. (2020). First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. Infection, 48(5), 773–777. https://doi.org/10.1007/s15010-020-01424-5
Zeng, M., Li, L., and Wu, Z. (2020). Traditional Chinese Medicine Lianhua Qingwen Treating corona Virus Disease 2019(COVID-19): Meta-Analysis of Randomized Controlled Trials. PLoS One, 15 (9),e0238828. doi:10.1371/journal.pone.0238828
Zhao, J., Tian, S., Lu, D., Yang, J., Zeng, H., Zhang, F., Tu, D., Ge, G., Zheng, Y., Shi, T., Xu, X., Zhao, S., Yang, Y., & Zhang, W. (2021). Systems pharmacological study illustrates the immune regulation, anti-infection, anti-inflammation, and multi-organ protection mechanism of Qing-Fei-Pai-Du decoction in the treatment of COVID-19. Phytomedicine : international journal of phytotherapy and phytopharmacology, 85, 153315. https://doi.org/10.1016/j.phymed.2020.153315
Zhao, Z. H., Zhou, Y., Li, W. H., Huang, Q. S., Tang, Z. H., and Li, H. (2020). Analysis of Traditional Chinese Medicine Diagnosis and Treatment Strategies for COVID-19 Based on "The Diagnosis and Treatment Program for Coronavirus Disease-2019" from Chinese Authority. Am. J. Chin. Med. 48 (5), 1035–1049. doi:10.1142/S0192415X20500500
Zhang, F., Liu, W., Huang, J., Chen, Q. long, Wang, D. dan, Zou, L. wei, Zhao, Y. fang, Zhang, W. dong, Xu, J. guang, Chen, H. zhuan, & Ge, G. bo. (2022). Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb–drug interactions in antiviral therapy. Acta Pharmacologica Sinica, 43(4), 1072–1081.https://doi.org/10.1038/s41401-021-0069 7-2
Zhang, J., Litvinova, M., Wang, W., Wang, Y., Deng, X., Chen, X., Li, M., Zheng, W., Yi, L., Chen, X., Wu, Q., Liang, Y., Wang, X., Yang, J., Sun, K., Longini, I. M., Halloran, M. E., Wu, P., Cowling, B. J., … Yu, H. (2020). Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study. The Lancet Infectious Diseases, 20(7), 793–802. https://doi.org/10.1016/S1473-3099(20)3 0230-9
Zhang, M., Yan, X., Shi, M., Li, R., Pi, Z., Ren, X., Wang, Y., Yan, S., Wang, Y., Jin, Y., & Wang, X. (2022). Safety and efficiency of stem cell therapy for COVID-19: a systematic review and meta-analysis. Global health research and policy, 7(1), 19. https://doi.org/10.1186/s41256-022-0025 1-5
Zhang, S., Yang, Z., Chen, Z. L., Li, Z. N., Yue, S. J., Li, J. J., & Tang, Y. P. (2022). Efficacy and Safety of "Three Chinese Patent Medicines and Three TCM Prescriptions" for COVID-19: A Systematic Review and Network Meta-Analysis. Evidence-based complementary and alternative medicine : eCAM, 2022, 4654793. https://doi.org/10.1155/2022/4654793
Zhang, Y., Xie, H., Li, Y., Li, T., Yuan, H., Fu, X., et al. (2020). Qingfei Paidu Decoction for Treating COVID-19: A Protocol for a Meta-Analysis and Systematic Review of Randomized Controlled Trials. Medicine, 99(36), e22040. doi:10.1097/MD.0000000000022040
Zheng, E. X., & Navarro, V. J. (2015). Liver Injury from Herbal, Dietary, and Weight Loss Supplements: a Review. Journal of clinical and translational hepatology, 3(2), 93–98. https://doi.org/10.14218/JCTH.2015.00006
Zhong, L. L. D., Lam, W. C., Yang, W., Chan, K. W., Sze, S. C. W., Miao, J., et al. (2020). Potential Targets for Treatment of Coronavirus Disease 2019 (COVID-19): A Review of Qing-Fei-Pai-Du-Tang and its Major Herbs. Am. J. Chin. Med. 48(5), 1051–1071. doi:10.1142/S0192415X20500512
Zhong, Y., Zhou, J., Liang, N., Liu, B., Lu, R., He, Y., Liang, C., Wu, J., Zhou, Y., Hu, M., & Zhou, J. (2017). Effect of Maxing Shigan Tang on H1N1 Influenza A Virus-Associated Acute Lung Injury in Mice. Intervirology, 59(5–6), 267–274.
Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. D., Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., Zheng, X. S., … Shi, Z. L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273. https://doi.org/10.1038/s41586-020-2012-7
Zhou, Z., Zhao, N., Shu, Y., Han, S., Chen, B., & Shu, X. (2020). Effect of Gastrointestinal Symptoms in Patients With COVID-19. Gastroenterology, 158(8), 2294–2297. https://doi.org/10.1053/j.gastro.2020.03.020
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., Niu, P., Zhan, F., Ma, X., Wang, D., Xu, W., Wu, G., Gao, G. F., & Tan, W. (2020). A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine, 382(8), 727–733. https://doi.org/10.1056/nejmoa2001017
Zhuang, J., Dai, X., Wu, Q., Cai, H., Fu, X., Zhang, W., & Chen, B. (2021). A meta-analysis for Lianhua Qingwen on the treatment of Coronavirus disease 2019 (COVID-19). Complementary therapies in medicine, 60, 102754. https://doi.org/10.1016/j.ctim.2021.102754