Formulation and Hair Growth Activity Test of Cinnamon Essential Oil (Cinnamomum burmannii) Nanoemulsion-Based Serum
Keywords:
Cinnamon, Nanoemulsion, Serum, Hair growth
Abstract
Baldness can result from hair loss, which can also affect a person's mental health. It is preferable to use natural hair growth products in place of synthetic ones because of their limits. It is possible for cinnamon essential oil (CEO) to promote hair growth. CEO's cinnamaldehyde molecule is irritative and has low stability, which is why it was encapsulated in a nanoemulsion system. The goal of this research is to create the ideal CEO nanoemulsion serum, which will meet all requirements, actively promote hair growth, and not irritate users when used. In this study, the formula was optimized using D-optimal design and the spontaneous nano emulsification method was utilized to generate the nanoemulsion. Characteristics of the cinnamon oil nanoemulsion serum (CEONS) included pH, viscosity, organoleptic, droplet size and polydispersity index, and stability. For 28 days, the Tanaka method was used to study the hair growth activity test in terms of the weight and length of the male rabbits' hair. An in vivo cutaneous acute irritation test was used to evaluate the safety of the product. Propylene glycol (34.905%), CEO (12.686%), and cremophor RH 40 (52.408%) made up the ideal CEONS formula. The substance has a colourless, transparent, clear, and distinct scent. It also has a little viscous viscosity, with a pH range of 5.1 to 5.196, is non-irritating, and is stable. With a mean hair length of 2.4 cm ± 0.308 and a hair weight of 1.36 ± 0.16 g, the ideal CEONS droplet size was 44.31 ± 0.3024 with a PDI value of 0.25 ± 0.004. This droplet size was also able to accelerate hair development. According to the study's findings, CEO has greater hair growth activity than traditional oils and can be combined to create CEONS.
References
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Gu, Y., Bian, Q., Zhou, Y., Huang, Q., dan Gao, J. (2022). Hair Follicle-Targeting Drug Delivery Strategies for The Management of Hair Follicle-associated Disorders. Asian Journal of Pharmaceutical Sciences, 17,333–352.
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Mandal, D., Shukla, A.C., dan Siddiqui, M.W. (2018). Sustainable Horticulture, Volume 2: Food, Health, and Nutrition. CRC Press, USA.
Masoud, F., Alamdari, H.A., Asnaashari, S., Shokri, J., dan Javadzadeh, Y. (2020). Efficacy and safety of a novel herbal solution for the treatment of androgenetic alopecia and comparison with 5% minoxidil: A double‐blind, randomized controlled trial study. Dermatologic Therapy, 33, 1–24.
Matos, B.N., Reis, T.A., Gratieri, T., dan Gelfuso, G.M. (2015). Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles. International Journal of Biological Macromolecules, 75, 225–229.
Namer, B., Seifert, F., Handwerker, H.O., dan Maih, C. (2005). TRPA1 and TRPM8 activation in humans: efects of cinnamaldehyde and menthol. Neuro Report, 16, 955–959.
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Pongsumpun, P., Iwamoto, S., dan Siripatrawan, U. (2020). Response surface methodology for optimization of cinnamon essential oil nanoemulsion with improved stability and antifungal activity. Ultrasonics Sonochemistry, 60, 1–10.
Savin, R.C. (1987). Use of Topical Minoxidil in The Treatment of Male Pattern Baldness. Journal of the American Academy of Dermatology, 16, 696–704.
Septiyanti, M., Liana, L., Sutriningsih, Kumayanjati, B., dan Meliana, Y. (2019). Formulation and evaluation of serum from red, brown and green algae extract for anti-aging base material. AIP Conference Proceedings, 2175, 1–11.
Shoviantari, F., Liziarmezilia, Z., Bahing, A., dan Agustina, L. (2019). Uji Aktivitas Tonik Rambut Nanoemulsi Minyak Kemiri (Aleurites moluccana L.). Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 6, 69–72.
Soesilawati, P. (2020). Histologi Kedokteran Dasar. Airlangga University Press.
Valizadeh, A., Shirzad, M., Esmaeili, F., dan Amani, A. (2018). Increased antibacterial activity of Cinnamon Oil Microemulsionin Comparison with Cinnamon Oil Bulk and Nanoemulsion. Nanomedicine Research Journal, 3, 37–43.
Vellayanti, S. (2020). 'Formulasi dan Karakterisasi Sediaan Serum Nanopartikel Emas Daun Tin', , Skripsi, . Universitas Islam Indonesia, Yogyakarta.
Vogt, A., Hadam, S., Deckert, I., Schmidt, J., Stroux, A., Afraz, Z., dkk. (2015). Hair follicle targeting, penetration enhancement and Langerhans cell activation make cyanoacrylate skin surface stripping a promising delivery technique for transcutaneous immunization with large molecules and particle-based vaccines. Experimental Dermatology, 24, 73–75.
Almas, J.F., Chasanah, U., dan Rahmasari, D. (2022). Activity of Hair Tonic Nanoemulsion with Candlenut Oil (Aleurites Moluccana) on Mice (Mus Musculus). KnE Medicine, 2022, 630–636.
Atmanto, D. (2019). Influence of the Addition of the Essential Oil of Cinnamon (Cinnamomum burmanii) in Soap Against Skin Care. KnE Social Sciences, 3, 587–595.
Chun, J.-Y., Jo, Y.-J., Bjrapha, P., Choi, M.-J., dan Min, S.-G. (2015). Antimicrobial Effect of α- or β-Cyclodextrin Complexes with Trans-Cinnamaldehyde Against Staphylococcus aureus and Escherichia coli. Drying Technology, 33,377–383.
Deng, Y., Huang, F., Wang, J., Zhang, Yumeng, Zhang, Yan, Su, G., dkk. (2021). Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability. Molecules, 26, 1–15.
Eid, A.M.M., Elmarzugi, N.A., dan El-Enshasy, H.A. (2013). Preparation and Evaluation Of Olive Oil Nanoemulsion Using Sucrose Monoester. International Journal of Pharmacy and Pharmaceutical Sciences, 5, 434–440.
Fajar, A., Ammar, G.A., Hamzah, M., Manurung, R., dan Yusuf, M. (2019). Effect of Tree Age on The Yield, Productivity, and Chemical Composition of Essential Oil from Cinnamomum burmannii. Current Research on Biosciences and Biotechnology, 1, 17–22.
Gu, Y., Bian, Q., Zhou, Y., Huang, Q., dan Gao, J. (2022). Hair Follicle-Targeting Drug Delivery Strategies for The Management of Hair Follicle-associated Disorders. Asian Journal of Pharmaceutical Sciences, 17,333–352.
Gull, A., Ahmed, S., Ahmad, F.J., Nagaich, U., dan Chandra, A. (2020). Hydrogel Thickened Microemulsion; A Local Cargo for The Co-delivery of Cinnamaldehyde and Berberine to Treat Acne vulgaris. Journal of Drug Delivery Science and Technology, 58, 1–10.
Guterres, S., Vidor Contri, R., Abrahão Frank, L., Kaiser, M., dan R. Pohlmann, A. (2014). The Use of Nanoencapsulation to Decrease Human Skin Irritation Caused by Capsaicinoids. International Journal of Nanomedicine, 9, 951–962.
Haliza, M.N., Amananti, W., dan Santoso, J. (2020). Formulasi Sediaan Serum Spray Ekstrak Pegagan (Centella asiatica L.) sebagai Anti-Aging Alami. Politeknik Harapan Bersama Tegal, 7, 1–6.
Hendradi, E., Chasanah, U., Indriani, T., dan Fionnayuristy, (2013). Pengaruh Gliserin dan Propilenglikol terhadap Karakteristik Fisik, Kimia dan SPF Sediaan Krim Tipe O/W Ekstrak Biji Kakao (Theobroma cacao L). PharmaScientia, 2, 31–42.
Hojland, C., Andersen, H., Poulsen, J., Arendt-Nielsen, L., dan Gazerani, P. (2015). A Human Surrogate Model of Itch Utilizing the TRPA1 Agonist Trans-cinnamaldehyde. Acta Dermato Venereologica, 95, 798–803.
Indriana, L., Pangkahila, W., dan Aman, I.G.M. (2018). Topical Application of Cinnamon (cinnamomum burmanii) Essential Oil has The Same Effectiveness as Minoxidil in Increasing Hair Length and Diameter Size of Hair Follicles in Male White Wistar Rats. Indonesia Journal of Anti-Aging Medicine, 2, 13–16.
Iswari, F.L., Retno, (2013). Buku Pegangan Ilmu Pengetahuan Kosmetik. Gramedia Pustaka Utama.
Jain, S.K., Verma, A., Jain, A., dan Hurkat, P. (2016). Transfollicular drug delivery: current perspectives. Research and Reports in Transdermal Drug Delivery, 1.
Kim, J.K., Zeb, A., Qureshi, O.S., Kim, Hyung-Seo, Cha, J.-H., dan Kim, Hoo-Seong, (2016). Improved skin permeation of methotrexate via nanosized ultradeformable liposomes. International Journal of Nanomedicine, 11, 3813–3824.
Listyorini, N.M.D., Wijayanti, N.L.P.D., dan Astuti, K.W. (2018). Optimasi Pembuatan Nanoemulsi Virgin Coconut Oil. Jurnal Kimia, 8–12.
Liu, Y., Liang, X., Zhang, R., Lan, W., dan Qin, W. (2017). Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing. Polymers, 9, 1–14.
Lopedota, A., Denora, N., Laquintana, V., Cutrignelli, A., Lopalco, A., Tricarico, D., dkk. (2018). Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-CyclodextrinInclusion Complex for Topical Alopecia Treatment. Journal of Pharmaceutical Sciences, 107, 1046–1054.
Mandal, D., Shukla, A.C., dan Siddiqui, M.W. (2018). Sustainable Horticulture, Volume 2: Food, Health, and Nutrition. CRC Press, USA.
Masoud, F., Alamdari, H.A., Asnaashari, S., Shokri, J., dan Javadzadeh, Y. (2020). Efficacy and safety of a novel herbal solution for the treatment of androgenetic alopecia and comparison with 5% minoxidil: A double‐blind, randomized controlled trial study. Dermatologic Therapy, 33, 1–24.
Matos, B.N., Reis, T.A., Gratieri, T., dan Gelfuso, G.M. (2015). Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles. International Journal of Biological Macromolecules, 75, 225–229.
Namer, B., Seifert, F., Handwerker, H.O., dan Maih, C. (2005). TRPA1 and TRPM8 activation in humans: efects of cinnamaldehyde and menthol. Neuro Report, 16, 955–959.
Ningrum, K.N. (2018). 'Efektivitas Hidrolisat Kolagen Ikan untuk Mencegah Kerontokan Rambut dalam Sediaan Serum Rambut', , Skripsi, . Institut Pertanian Bogor, Bogor.
Plumeriastuti, H., Budiastuti, B., Effendi, M., dan Budiarto, B. (2019). Identification of bioactive compound of the essential oils of Cinnamomum burmannii from several areas in Indonesia by gas chromatography-mass spectrometry method for antidiabetic potential. National Journal of Physiology, Pharmacy and Pharmacology, 8, 279–283.
Pongsumpun, P., Iwamoto, S., dan Siripatrawan, U. (2020). Response surface methodology for optimization of cinnamon essential oil nanoemulsion with improved stability and antifungal activity. Ultrasonics Sonochemistry, 60, 1–10.
Savin, R.C. (1987). Use of Topical Minoxidil in The Treatment of Male Pattern Baldness. Journal of the American Academy of Dermatology, 16, 696–704.
Septiyanti, M., Liana, L., Sutriningsih, Kumayanjati, B., dan Meliana, Y. (2019). Formulation and evaluation of serum from red, brown and green algae extract for anti-aging base material. AIP Conference Proceedings, 2175, 1–11.
Shoviantari, F., Liziarmezilia, Z., Bahing, A., dan Agustina, L. (2019). Uji Aktivitas Tonik Rambut Nanoemulsi Minyak Kemiri (Aleurites moluccana L.). Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 6, 69–72.
Soesilawati, P. (2020). Histologi Kedokteran Dasar. Airlangga University Press.
Valizadeh, A., Shirzad, M., Esmaeili, F., dan Amani, A. (2018). Increased antibacterial activity of Cinnamon Oil Microemulsionin Comparison with Cinnamon Oil Bulk and Nanoemulsion. Nanomedicine Research Journal, 3, 37–43.
Vellayanti, S. (2020). 'Formulasi dan Karakterisasi Sediaan Serum Nanopartikel Emas Daun Tin', , Skripsi, . Universitas Islam Indonesia, Yogyakarta.
Vogt, A., Hadam, S., Deckert, I., Schmidt, J., Stroux, A., Afraz, Z., dkk. (2015). Hair follicle targeting, penetration enhancement and Langerhans cell activation make cyanoacrylate skin surface stripping a promising delivery technique for transcutaneous immunization with large molecules and particle-based vaccines. Experimental Dermatology, 24, 73–75.
Published
2024-12-19
How to Cite
Wayan Cintya Ganes Budastra, Teti Mariam Riandari, Lusiana Afri Anggini Lumbangaol, Laras Novitasari, Retno Murwanti, & Ronny Martien. (2024). Formulation and Hair Growth Activity Test of Cinnamon Essential Oil (Cinnamomum burmannii) Nanoemulsion-Based Serum. Indonesian Journal of Pharmacy. https://doi.org/10.22146/ijp.11179
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Research Article
