Effectiveness of disinfectants against methicillin resistant Staphylococcus aureus (MRSA) contamination in hospital: a review
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) contamination is still widely reported in various hospital areas. Despite routine cleaning and preventive measures in places such as hospitals, the prevalence of MRSA is still increasing worldwide, especially in Asia. This review aimed to evaluate the effectiveness of disinfectants against MRSA contamination in hospitals. Articles were searched from PubMed, ScienceDirect, Cochrane, and Google Scholar databases using specific keywords and boolean operators. Journal selection from these databases was based on inclusion criteria, exclusion criteria, and PICOS framework. Studies that did not fit the topic or study design and had paid access and duplication were excluded. A total of five valid and reliable articles found that some disinfectants, such as JUC Polymer, a combination of hydrogen peroxide (H2O2) and silver cations (Ag), have effectiveness in eradicating germs or inhibiting the growth of MRSA germs. The application of disinfectants in MRSA also showed benefits in terms of cost. However, the use of disinfectants needs to be considered because they can cause tolerance and resistance. In conclusion, MRSA disinfectants are still proven effective with various methods and precautions. In addition, disinfectants are beneficial in terms of prevention and health financing.
References
Schaumburg F, Alabi AS, Peters G, Becker K. New epidemiology of Staphylococcus aureus infection in Africa. Clin Microbiol Infect 2014; 20(7):589–96.
Tatiya-aphiradee N, Chatuphonprasert W, Jarukamjorn K. Anti-inflammatory effect of Garcinia mangostana Linn. pericarp extract in methicillin-resistant Staphylococcus aureus-induced superficial skin infection in mice. Biomed Pharmacother 2019; 111:705–13.
https://doi.org/10.1016/j.biopha.2018.12.142
Gurung RR, Maharjan P, Chhetri GG. Antibiotic resistance pattern of Staphylococcus aureus with reference to MRSA isolates from pediatric patients. Future science OA 2020; 6(4):FSO464.
https://doi.org/10.2144/fsoa-2019-0122
Lounsbury N, Reeber MG, Mina G, Chbib C. A mini-review on ceftaroline in bacteremia patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. Antibiotics 2019; 8(1):30.
https://doi.org/10.3390/antibiotics8010030
Torres A, Kuraieva A, Stone GG, Cillóniz C. Systematic review of ceftaroline fosamil in the management of patients with methicillin-resistant Staphylococcus aureus pneumonia. Eur Respir Rev 2023; 32(170):320117.
https://doi.org/10.1183/16000617.0117-2023
Hammond J, Benigno M, Bleibdrey N, Ansari W, Nguyen JL. Ceftaroline fosamil for the treatment of methicillin-resistant Staphylococcus aureus bacteremia: a real-world comparative clinical outcomes study. Drugs Real World Outcomes 2024; 11(2):273-83.
https://doi.org/10.1007/s40801-024-00422-5
Cimolai N. MRSA and the environment: implications for comprehensive control measures. Eur J Clin Microbiol Infect Dis 2008; 27(7):481-93.
https://doi.org/10.1007/s10096-008-0471-0
Bartels MD, Kristoffersen K, Slotsbjerg T, Rohde SM, Lundgren B, Westh H. Environmental meticillin-resistant Staphylococcus aureus (MRSA) disinfection using dry-mist-generated hydrogen peroxide. J Hosp Infect 2008; 70(1):35–41.
https://doi.org/10.1016/j.jhin.2008.05.018
Haddadin AS, Fappiano SA, Lipsett PA. Methicillin resistant Staphylococcus aureus (MRSA) in the intensive care unit. Postgrad Med J 2002; 78(921):385-92.
https://doi.org/10.1136/pmj.78.921.385
Gong Y, Peng Y, Luo X, Zhang C, Shi Y, Zhang Y, et al. Different infection profiles and antimicrobial resistance patterns between burn ICU and common wards. Front Cell Infect Microbiol 2021; 11:681731.
https://doi.org/10.3389/fcimb.2021.681731
Sadsad R, Sintchenko V, McDonnell GD, Gilbert GL. Effectiveness of hospital-wide methicillin-resistant Staphylococcus aureus (MRSA) infection control policies differs by ward specialty. PLoS One 2013; 8(12):e83099.
https://doi.org/10.1371/journal.pone.0083099
Yuen JWM, Chung TWK, Loke AY. Methicillin-resistant Staphylococcus aureus (MRSA) contamination in bedside surfaces of a hospital ward and the potential effectiveness of enhanced disinfection with an antimicrobial polymer surfactant. Int J Environ Res Public Health 2015; 12(3):3026–41.
https://doi.org/10.3390/ijerph120303026
Hassoun A, Linden PK, Friedman B. Incidence, prevalence, and management of MRSA bacteremia across patient populations-a review of recent developments in MRSA management and treatment. Crit Care 2017; 21(1):211.
https://doi.org/10.1186/s13054-017-1801-3
Pannewick B, Baier C, Schwab F, Vonberg RP. Infection control measures in nosocomial MRSA outbreaks—Results of a systematic analysis. PLoS One 2021; 16(4):e0249837.
https://doi.org/10.1371/journal.pone.0249837
Rodríguez-Villodres Á, Martín-Gandul C, Peñalva G, Guisado-Gil AB, Crespo-Rivas JC, Pachón-Ibáñez ME, et al. Prevalence and risk factors for multidrug-resistant organisms colonization in long-term care facilities around the world: A review. Antibiotics 2021; 10(6):680.
https://doi.org/10.3390/antibiotics10060680
Mendes RE, Mendoza M, Banga Singh KK, Castanheira M, Bell JM, Turnidge JD, et al. Regional resistance surveillance program results for 12 Asia-Pacific nations (2011). Antimicrob Agents Chemother 2013; 57(11):5721–6.
https://doi.org/10.1128/AAC.01121-13
Kuntaman K, Hadi U, Setiawan F, Koendori EB, Rusli M, Santosaningsih D, et al. Prevalence of methicillin resistant Staphylococcus aureus from nose and throat of patients on admission to medical wards of Dr Soetomo hospital, Surabaya, Indonesia. Southeast Asian J Trop Med Public Health 2016; 47(1):66–70.
Santosaningsih D, Santoso S, Setijowati N, Rasyid HA, Budayanti NS, Suata K, et al. Prevalence and characterization of Staphylococcus aureus causing community-acquired skin and soft tissue infections on Java and Bali, Indonesia. Trop Med Int Health 2018; 21(1)34-44.
https://doi.org/10.1111/tmi.13000
Gagné D, Bédard G, Maziade PJ. Systematic patients’ hand disinfection: Impact on meticillin-resistant Staphylococcus aureus infection rates in a community hospital. J Hosp Infect 2010; 75(4):269-72.
https://doi.org/10.1016/j.jhin.2010.02.028
Rethlefsen ML, Kirtley S, Waffenschmidt S, Ayala AP, Moher D, Page MJ, et al. PRISMA-S: an extension to the PRISMA statement for reporting literature searches in systematic reviews. Syst Rev 1987; 30:385-6.
Yang M, Feng Y, Yuan L, Zhao H, Gao S, Li Z. High concentration and frequent application of disinfection increase the detection of methicillin-resistant Staphylococcus aureus infections in psychiatric hospitals during the COVID-19 pandemic. Front Med 2021; 8:722219.
https://doi.org/10.3389/fmed.2021.722219
Gerba CP. Quaternary ammonium biocides: efficacy in application. Appl Environ Microbiol 2015; 81(2):464-9.
https://doi.org/10.1128/AEM.02633-14
Xiao S, Yuan Z, Huang Y. Disinfectants against SARS-CoV-2: a review. Viruses 2022; 14(8):1721.
https://doi.org/10.3390/v14081721
Alkawareek MY, Bahlool A, Abulateefeh SR, Alkilany AM. Synergistic antibacterial activity of silver nanoparticles and hydrogen peroxide. PLoS One 2019; 14(8):e0220575.
https://doi.org/10.1371/journal.pone.0220575
Rahmi KA, Purwono PB, Rochmanti M. Benzalkonium chloride effectiveness as a disinfectant against hospital-associated methicillin-resistant Staphylococcus aureus (HA-MRSA). Malays J Microbiol 2019; 15(2):88-94.
https://doi.org/10.21161/mjm.180035
Weber DJ, Sickbert-Bennett EE, Kanamori H, Rutala WA. New and emerging infectious diseases (Ebola, Middle Eastern respiratory syndrome coronavirus, carbapenem-resistant Enterobacteriaceae, Candida auris): focus on environmental survival and germicide susceptibility. Am J Infect Control 2019; 47:A29-38.
https://doi.org/10.1016/j.ajic.2019.03.004
Gordon RJ, Lowy FD. Pathogenesis of methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis 2008; 46(Suppl 5):s350-9.
https://doi.org/10.1086/533591
He GX, Landry M, Chen H, Thorpe C, Walsh D, Varela MF, et al. Detection of benzalkonium chloride resistance in community environmental isolates of staphylococci. J Med Microbiol 2014; 63(Pt 5):735-41.
https://doi.org/10.1099/jmm.0.073072-0
Reiter KC, Machado ABMP, de Freitas ALP, Barth AL. High prevalence of methicillin-resistant Staphylococcus aureus with SCCmec type III in cystic fibrosis patients in southern Brazil. Rev Soc Bras Med Trop 2010; 43(4):377-81.
https://doi.org/10.1590/s0037-86822010000400008
Shoaib M, Aqib AI, Muzammil I, Majeed N, Bhutta ZA, Kulyar MFEA, et al. MRSA compendium of epidemiology, transmission, pathophysiology, treatment, and prevention within one health framework. Front Microbiol 2023; 13:1067284.
https://doi.org/10.3389/fmicb.2022.1067284
Souverein D, Houtman P, Euser SM, Herpers BL, Kluytmans J, Den Boer JW. Costs and benefits associated with the MRSA search and destroy policy in a hospital in the Region Kennemerland, The Netherlands. PLoS One 2016; 11(2):e0148175.
https://doi.org/10.1371/journal.pone.0148175
Kim T, Oh PI, Simor AE. The economic impact of methicillin-resistant Staphylococcus aureus in Canadian hospitals. Infect Control Hosp Epid 2001; 22(2):99-104.