Can High Flow Nasal Cannula Prevent Intubation in Status Asthmaticus?”: A Case Report
Abstract
Overview of the case: A 29-year-old male with status asthmaticus, the GCS score was 14, the respiratory rate was 30 x/min, SpO2 88% on room air, bilateral lung wheezing, and the blood gas analysis revealed severe respiratory acidosis. Management: Treatment involved High Flow Nasal Cannula (HFNC) oxygenation, salbutamol and ipratropium bromide nebulization, aminophylline drip infusion, and intravenous corticosteroids. Within hours, there was a significant improvement in respiratory parameters and acidosis. Subsequent monitoring in the intensive care unit showed improvement, the patient successfully being weaned off HFNC and transferred to the general ward after six days. This case highlights the efficacy of HFNC in managing severe asthma exacerbation and preventing intubation. Results: The use of HFNC, when combined with standard asthma management, has proven to be a promising option in the non-invasive management of status asthmaticus and can prevent intubation, but should be monitored carefully due to the risk of delayed escalation to respiratory support
References
Saputra I, Handayani D, Kaffah S. Penggunaan indeks respiratory-oxygnation dalam menentukan keberhasilan terapi oksigen high flow nasal cannula pada anak sakit kritis dengan distres napas. Sari Pediatri. 2023; 24(5), 352-58. Doi: https://doi.org/10.14238/sp24.5.2023.352-8
Milési C, Boubal M, Jacquot A, Baleine J, Durand S, Odena MP, et al. High-flow nasal cannula: recommendations for daily practice in pediatrics. Ann Intensive Care. 2014;4(29):1-7. Doi: 10.1186/s13613-014-0029-5
Dysart K, Miller TL, Wolfson MR, Shaffer TH. Research in high flow therapy: mechanisms of action. Respir Med. 2009;103(10):1400–5. Doi: 10.1016/j.rmed.2009.04.007
Roca O , Caralt B, Messika J, Samper M, Sztrymf B, Hernández G, et al. An index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med. 2019;199 (11): 1368-376. Doi: 10.1164/rccm.201803-0589OC
Baudin F, Buisson A, Vanel B, Massenavette B, Pouyau R, Javouhey E. Nasal high flow in management of children with status asthmaticus: a retrospective observational study. Ann Intensive Care. 2017;7(1):1-9 . Doi: https://doi.org/10.1186/s13613-017-0278-1
Chao KY, Chien YH, Mu SC. High-flow nasal cannula in children with asthma exacerbation: A review of current evidence. Paediatric Respiratory Reviews. 2021;40:52-57. Doi:10.1016/j.prrv.2021.01.003
Copyright (c) 2026 Ihsan Hamdani, Artha Wahyu Wardana

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
The Contributor and the company/institution agree that all copies of the Final Published
Version or any part thereof distributed or posted by them in print or electronic format as permitted herein will include the notice of copyright as stipulated in the Journal and a full citation to the Journal.



